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Erschienen in: Current Pain and Headache Reports 10/2018

01.10.2018 | Concussion and Head Injury (A Finkel, Section Editor)

Strides Toward Better Understanding of Post-Traumatic Headache Pathophysiology Using Animal Models

verfasst von: Dara Bree, Dan Levy

Erschienen in: Current Pain and Headache Reports | Ausgabe 10/2018

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Abstract

Purpose of Review

In recent years, the awareness of the detrimental impact of concussion and mild traumatic brain injuries (mTBI) is becoming more apparent. Concussive head trauma results in a constellation of cognitive and somatic symptoms of which post-traumatic headache is the most common. Our understanding of post-traumatic headache is limited by the paucity of well validated, characterized, and clinically relevant animal models with strong predictive validity. In this review, we aim to summarize and discuss current animal models of concussion/mTBI and related data that start to shed light on the pathophysiology of post-traumatic headache.

Recent Findings

Each of the models will be discussed in terms of their face, construct, and predictive validity as well as overall translational relevance to concussion, mTBI, and post-traumatic headache. Significant contributions to the pathophysiology of PTH garnered from these models are discussed as well as potential contributors to the development of chronic post-traumatic headache.

Summary

Although post-traumatic headache is one of the most common symptoms following mild head trauma, there remains a disconnect between the study of mild traumatic brain injury and headache in the pre-clinical literature. A greater understanding of the relationship between these phenomena is currently needed to provide more insight into the increasing frequency of this debilitating condition in both military and civilian populations.
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Metadaten
Titel
Strides Toward Better Understanding of Post-Traumatic Headache Pathophysiology Using Animal Models
verfasst von
Dara Bree
Dan Levy
Publikationsdatum
01.10.2018
Verlag
Springer US
Erschienen in
Current Pain and Headache Reports / Ausgabe 10/2018
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-018-0720-6

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