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Brain Tumor Pathology

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23.06.2018 | Original Article

Stromal cells of hemangioblastomas exhibit mesenchymal stem cell-derived vascular progenitor cell properties

verfasst von: Shigeki Takada, Masato Hojo, Noriyoshi Takebe, Kenji Tanigaki, Susumu Miyamoto

Erschienen in: Brain Tumor Pathology | Ausgabe 4/2018

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Abstract

Hemangioblastoma is composed of neoplastic stromal cells and a prominent capillary network. To date, the identity of stromal cells remains unclear. Mesenchymal stem cells can give rise to committed vascular progenitor cells, and ephrin-B2/EphB4 and Notch signaling have crucial roles in these steps. The aim of our study was to elucidate that stromal cells of central nervous system hemangioblastomas have mesenchymal stem cell-derived vascular progenitor cell properties. Ten hemangioblastomas were investigated immunohistochemically. CD44, a mesenchymal stem cell marker, was detected in stromal cells of all cases, suggesting that stromal cells have mesenchymal stem cell-like properties. Neither CD31 nor α-SMA was expressed in stromal cells, suggesting that stromal cells have not acquired differentiated vascular cell properties. Both ephrin-B2 and EphB4, immature vascular cell markers, were detected in stromal cells of all cases. Jagged1, Notch1, and Hesr2/Hey2, which are known to be detected in both immature endothelial cells and mural cells, were expressed in stromal cells of all cases. Notch3, which is known to be detected in differentiating mural cells, was also expressed in all cases. These results suggest that stromal cells also have vascular progenitor cell properties. In conclusion, stromal cells of hemangioblastomas exhibit mesenchymal stem cell-derived vascular progenitor cell properties.

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Titel: Stromal cells of hemangioblastomas exhibit mesenchymal stem cell-derived vascular progenitor cell properties
verfasst von: Shigeki Takada
Masato Hojo
Noriyoshi Takebe
Kenji Tanigaki
Susumu Miyamoto
Publikationsdatum: 23.06.2018
Verlag: Springer Singapore
Erschienen in: Brain Tumor Pathology / Ausgabe 4/2018
Print ISSN: 1433-7398
Elektronische ISSN: 1861-387X
DOI: https://doi.org/10.1007/s10014-018-0323-2

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Stromal cells of hemangioblastomas exhibit mesenchymal stem cell-derived vascular progenitor cell properties

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