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29.03.2017 | Brief Report

Structural basis of Zika virus methyltransferase inhibition by sinefungin

verfasst von: Kamil Hercik, Jiri Brynda, Radim Nencka, Evzen Boura

Erschienen in: Archives of Virology | Ausgabe 7/2017

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Abstract

Zika virus is considered a major global threat to human kind. Here, we present a crystal structure of one of its essential enzymes, the methyltransferase, with the inhibitor sinefungin. This structure, together with previously solved structures with bound substrates, will provide the information needed for rational inhibitor design. Based on the structural data we suggest the modification of the adenine moiety of sinefungin to increase selectivity and to covalently link it to a GTP analogue, to increase the affinity of the synthesized compounds.

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Titel: Structural basis of Zika virus methyltransferase inhibition by sinefungin
verfasst von: Kamil Hercik
Jiri Brynda
Radim Nencka
Evzen Boura
Publikationsdatum: 29.03.2017
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 7/2017
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-017-3345-x

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Structural basis of Zika virus methyltransferase inhibition by sinefungin

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