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Erschienen in: Brain Structure and Function 2/2022

26.06.2021 | Original Article

Structural perisylvian asymmetry in naturally occurring atypical language dominance

verfasst von: Robin Gerrits, Helena Verhelst, Thijs Dhollander, Li Xiang, Guy Vingerhoets

Erschienen in: Brain Structure and Function | Ausgabe 2/2022

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Abstract

Functional and anatomical hemispheric asymmetries abound in the neural language system, yet the relationship between them remains elusive. One attractive proposal is that structural interhemispheric differences reflect or even drive functional language laterality. However, studies on structure–function couplings either find that left and right language dominant individuals display similar leftward structural asymmetry or yield inconsistent results. The current study aimed to replicate and extend prior work by comparing structural asymmetries between neurologically healthy left-handers with right hemispheric language dominance (N = 24) and typically lateralized left-handed controls (N = 39). Based on structural MRI data, anatomical measures of six ‘language-related’ perisylvian structures were derived, including the surface area of five gray matter regions with known language functions and the FDC (combined fiber density and fiber-bundle cross-sectional area) of the arcuate fasciculus. Only the surface area of the pars triangularis and the anterior insula differed significantly between participant groups, being on average leftward asymmetric in those with typical dominance, but right lateralized in volunteers with atypical language specialization. However, these findings did not survive multiple testing correction and the asymmetry of these structures demonstrated much inter-individual variability in either subgroup. By integrating our findings with those reported previously we conclude that while some perisylvian anatomical asymmetries may differ subtly between typical and atypical speech dominants at the group level, they serve as poor participant-specific predictors of hemispheric language specialization.
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Metadaten
Titel
Structural perisylvian asymmetry in naturally occurring atypical language dominance
verfasst von
Robin Gerrits
Helena Verhelst
Thijs Dhollander
Li Xiang
Guy Vingerhoets
Publikationsdatum
26.06.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Brain Structure and Function / Ausgabe 2/2022
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-021-02323-7