Background
Methods
Clinical tissue samples
Variable |
N
| CDH4 mRNA |
P
|
---|---|---|---|
Median (mean, range) | |||
Gender | 0.137 | ||
Female | 28 | 0.088(0.190, 0.019–1.367) | |
Male | 114 | 0.075(0.141, 0.012–2.661) | |
Age | 0.539 | ||
<65 | 99 | 0.080(0.167, 0.013–2.661) | |
≥65 | 43 | 0.074(0.115, 0.012–0.517) | |
Grade |
0.013*
| ||
“High”–“middle” | 71 | 0.068(0.119,0.012-0.932) | |
“Middle-low”–“low” | 63 | 0.108(0.197,0.013-2.661) | |
Censoring | 8 | 0.053(0.071,0.022-0.175) | |
Histotype |
0.001*
| ||
Squamous | 77 | 0.067(0.116, 0.012–1.367) | |
Adenocarcinoma | 58 | 0.125(0.203, 0.013–2.661) | |
Others | 3 | 0.084(0.096, 0.081–0.125) | |
SCLC | 4 | 0.108(0.106,0.069-0.139) | |
Lymph node metastasis | 0.733 | ||
0 | 69 | 0.092(0.161, 0.012–1.367) | |
1 | 21 | 0.067(0.113, 0.013–0.408) | |
2–3 | 26 | 0.073(0.187, 0.016–2.661) | |
4–24 | 24 | 0.086(0.120, 0.020–0.517) | |
Censoring | 2 | 0.100(0.100, 0.078–0.123) | |
Stage | 0.580 | ||
I–II | 96 | 0.082(0.172, 0.012–2.661) | |
III–IV | 46 | 0.079(0.106, 0.020–0.517) | |
Family history | 0.404 | ||
Yes | 25 | 0.070(0.115, 0.012–0.666) | |
No | 105 | 0.083(0.167, 0.013–2.661) | |
Censoring | 12 | 0.070(0.085, 0.040–0.172) | |
Smoking state | 0.476 | ||
Yes | 100 | 0.083(0.149,0.012-2.661) | |
No | 31 | 0.080(0.180, 0.019–1.367) | |
Censoring | 11 | 0.072(0.088, 0.040–0.172) | |
Drinking state | 0.216 | ||
Yes | 73 | 0.068(0.164, 0.013–2.661) | |
No | 58 | 0.090(0.146, 0.012–1.367) | |
Censoring | 11 | 0.072(0.088, 0.040–0.172) |
Reverse transcription PCR
Statistical analysis
Results
Correlation of CDH4 mRNA expression with clinical parameters of lung cancer patients
CDH4 mRNA expression in lung cancer tissues and normal tissues
Median (mean, range) |
P value | |
---|---|---|
Normal | 0.26(0.32, 0.03–3.01) | <0.001
|
Cancer | 0.08(0.15, 0.01–2.66) |