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05.08.2024 | Original Paper

Study on the chemical composition and anti-fungi activities of anthraquinones and its glycosides from Rumex japonicus Houtt.

verfasst von: He Sun, Dandan Xiao, Xue Li, Tong Sun, Fanying Meng, Xinting Shao, Yuling Ding, Yong Li

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2024

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Abstract

Fungi, such as Trichophyton rubrum (T. rubrum) and Microsporum canis Bodin Anamorph (M. canis Bodin Anamorph) are the main pathogens of dermatophysis. According to ancient books records, Rumex japonicus Houtt. (RJH) has a miraculous effect on the treatment of dermatophysis. To reveal the anti-fungi (T. rubrum and M. canis Bodin Anamorph) components and its mechanism of the Rumex japonicus Houtt. The vinegar extraction and alcohol precipitation, HPLC and nuclear magnetic resonance spectroscopy (NMR) were employed for analyzing the chemical compositions of RJH; in vitro anti-fungal experiment was investigated including test the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC), spore germination rate, nucleic acid, protein leakage rate, biofilm structure, and the mechanism of anti-fungal and anti-fungal biofilms in RJH. Seven anthraquinones and their glycoside compounds were obtained in this study respectively, such as chrysophanol, physcion, aloe-emodin, emodin, rhein, emodin-8-O-β-D-glucoside and chrysophanol-8-O-β-D-glucoside. In vitro anti-fungal experiment results showed that RJH extracts have good anti-fungal activity for dermatophytic fungi. Among them, the MIC of the rhein, emodin and aloe-emodin against T. rubrum are 1.9 µg/ml, 3.9 µg/ml and 15.6 µg/ml, respectively; the MIC of emodin and aloe-emodin against M. canis Bodin Anamorph are 7.8 µg/ml and 62.5 µg/ml, respectively. In addition, its active components can inhibit fungal spore germination and the formation of bud tube, change cell membrane permeability, prevent hyphal growth, destroy biofilm structure, and down-regulate the expression of agglutinin-like sequence family 1 of the adhesion phase of biofilm growth. The study shows that RJH play a fungicidal role.

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Titel: Study on the chemical composition and anti-fungi activities of anthraquinones and its glycosides from Rumex japonicus Houtt.
verfasst von: He Sun
Dandan Xiao
Xue Li
Tong Sun
Fanying Meng
Xinting Shao
Yuling Ding
Yong Li
Publikationsdatum: 05.08.2024
Verlag: Springer Nature Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2024
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-024-01834-x

Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata

Original Paper

Correction: Visualizing the spatial distribution of ustalic acid in the fruiting body of Tricholoma kakishimeji

Correction

Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus

Note

Eleven new glycosidic acid methyl esters from the crude resin glycoside fraction of Ipomoea alba seeds

Note

Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China

Natural Resource Letter

Byakangelicin alleviates sepsis-associated acute kidney injury by inhibiting inflammation and apoptosis

Note

Springer Medizin

Study on the chemical composition and anti-fungi activities of anthraquinones and its glycosides from Rumex japonicus Houtt.

Abstract

Graphic abstract

Weitere Artikel der Ausgabe 4/2024

Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata

Correction: Visualizing the spatial distribution of ustalic acid in the fruiting body of Tricholoma kakishimeji

Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus

Eleven new glycosidic acid methyl esters from the crude resin glycoside fraction of Ipomoea alba seeds

Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China

Byakangelicin alleviates sepsis-associated acute kidney injury by inhibiting inflammation and apoptosis

Springer Medizin

Abstract

Graphic abstract

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Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata

Correction: Visualizing the spatial distribution of ustalic acid in the fruiting body of Tricholoma kakishimeji

Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus

Eleven new glycosidic acid methyl esters from the crude resin glycoside fraction of Ipomoea alba seeds

Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China

Byakangelicin alleviates sepsis-associated acute kidney injury by inhibiting inflammation and apoptosis