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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Endocrine Disorders 1/2015

Subclinical and clinical hypothyroidism and non-alcoholic fatty liver disease: a cross-sectional study of a random population sample aged 18 to 65 years

Zeitschrift:
BMC Endocrine Disorders > Ausgabe 1/2015
Autoren:
Ulla Ludwig, Daniela Holzner, Christian Denzer, Artur Greinert, Mark Martin Haenle, Suemeyra Oeztuerk, Wolfgang Koenig, Bernhard Otto Boehm, Richard Andrew Mason, Wolfgang Kratzer, Tilmann Graeter, the EMIL-Study
Wichtige Hinweise
Ulla Ludwig and Daniela Holzner contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

UL and DH wrote the manuscript. MMH, SO, WKoe, BOB, WK were involved in the design and conduction of the study. MMH, SO, WKoe, BOB and TG collected and analysed the data. AG, CD, WK were involved in data interpretation and manuscript writing. All authors read and approved the final manuscript.

Abstract

Background

Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide. Recently, a correlation between thyroid dysfunction and NAFLD has been discussed. Objective of the present study was to investigate the association between thyroid dysfunction and hepatic steatosis.

Methods

Data from 2,445 subjects (51.7 % females) aged 18 to 65 years participating in a population-based cross-sectional study were assessed based on a standardized questionnaire and documentation of physical, biochemical and ultrasonographic findings. After application of exclusion criteria, a total of 1,276 subjects were included in the study collective. The influence of potential factors on the development of hepatic steatosis was assessed using multivariate logistic regression.

Results

The prevalence of hepatic steatosis in the study collective was 27.4 % (n = 349). The serum thyroxin (TT4) concentration in subjects with hepatic steatosis was reduced (p = 0.0004). Adjusting for age, or BMI, there was an increased prevalence of hepatic steatosis in subjects with reduced TT4 concentrations (p = 0.0143; p = <.0001).

Conclusions

The findings of the present study confirm an association between both subclinical and clinical hypothyroidism and hepatic steatosis
Literatur
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