Erschienen in:
01.06.2014 | Correspondence
Subgroup-specific localization of human medulloblastoma based on pre-operative MRI
verfasst von:
Annika K. Wefers, Monika Warmuth-Metz, Julia Pöschl, André O. von Bueren, Camelia-Maria Monoranu, Klaus Seelos, Aurelia Peraud, Jörg-Christian Tonn, Arend Koch, Torsten Pietsch, Christel Herold-Mende, Christian Mawrin, Antoinette Schouten-van Meeteren, Dannis van Vuurden, Katja von Hoff, Stefan Rutkowski, Stefan M. Pfister, Marcel Kool, Ulrich Schüller
Erschienen in:
Acta Neuropathologica
|
Ausgabe 6/2014
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Excerpt
Medulloblastoma (MB) is a group of malignant pediatric brain tumors arising in the posterior fossa. These tumors are classified into four molecular subgroups, namely WNT-, SHH-, Group 3- and Group 4-MB [
6]. In mice, SHH-MBs arise from granule cell precursors of the cerebellum and the cochlear nucleus [
2,
5], while WNT-MBs originate from dorsal brainstem precursors [
1]. In order to unravel a possible relation between human MB biology and localization, and to provide novel hints regarding the cellular origin of MB, we characterized localization patterns of 71 human MBs using pre-operative MRI. Molecular MB subgrouping was established via gene expression profiling as described [
4] and MRIs were analyzed blinded. Cohort details are summarized in Supplementary Fig. 1 and Supplementary Table 1. …
