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2021 | Substanzabusus und Sucht | OriginalPaper | Buchkapitel

7. Medikamente zur Behandlung von Abhängigkeitserkrankungen und abhängigem Verhalten

verfasst von : Prof. Dr. med. Falk Kiefer, Otto Benkert

Erschienen in: Kompendium der Psychiatrischen Pharmakotherapie

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Indikationen, Wirkungsweise, Nebenwirkungen und Risiken, Kontraindikationen und Interaktionen werden für die Medikamente zur Behandlung von Abhängigkeit und Entzugssyndromen beschrieben. Der Aufbau dieses Kapitels unterscheidet sich insofern von den anderen Kapiteln als die einzelnen Suchtmittel die Struktur vorgeben.
Literatur
Zurück zum Zitat Andresen-Streichert H, Müller A, Glahn A et al (2018) Alkoholmarker bei klinischen und forensischen Fragestellungen. Dtsch Arztebl 115(18):309–315 Andresen-Streichert H, Müller A, Glahn A et al (2018) Alkoholmarker bei klinischen und forensischen Fragestellungen. Dtsch Arztebl 115(18):309–315
Zurück zum Zitat Anton RF, Latham P, Voronin K et al (2020) Efficacy of Gabapentin for the treatment of alcohol use disorder in patients with alcohol withdrawal symptoms: a randomized clinical trial. JAMA Intern Med 180(5):1–9CrossRef Anton RF, Latham P, Voronin K et al (2020) Efficacy of Gabapentin for the treatment of alcohol use disorder in patients with alcohol withdrawal symptoms: a randomized clinical trial. JAMA Intern Med 180(5):1–9CrossRef
Zurück zum Zitat Barrio P, Ortega L, Guardia J et al (2018) Who receives nalmefene and how does it work in the real world? A single-arm, phase IV study of nalmefene in alcohol dependent outpatients: baseline and 1-month results. Clin Drug Investig 38(2):147–155CrossRef Barrio P, Ortega L, Guardia J et al (2018) Who receives nalmefene and how does it work in the real world? A single-arm, phase IV study of nalmefene in alcohol dependent outpatients: baseline and 1-month results. Clin Drug Investig 38(2):147–155CrossRef
Zurück zum Zitat Bell J, Strang J (2020) Medication treatment of opioid use disorder. Biol Psychiatry 87(1):82–88CrossRef Bell J, Strang J (2020) Medication treatment of opioid use disorder. Biol Psychiatry 87(1):82–88CrossRef
Zurück zum Zitat Black N, Stockings E, Campbell G et al (2019) Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis. Lancet Psychiatry 6(12):995–1010CrossRef Black N, Stockings E, Campbell G et al (2019) Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis. Lancet Psychiatry 6(12):995–1010CrossRef
Zurück zum Zitat Bschor T, Henssler J, Müller M, Baethge C (2018) Baclofen for alcohol use disorder-a systematic meta-analysis. Acta Psychiatr Scand 138(3):232–242CrossRef Bschor T, Henssler J, Müller M, Baethge C (2018) Baclofen for alcohol use disorder-a systematic meta-analysis. Acta Psychiatr Scand 138(3):232–242CrossRef
Zurück zum Zitat Carney G, Bassett K, Maclure M et al (2020) Cardiovascular and neuropsychiatric safety of smoking cessation pharmacotherapies in non-depressed adults: a retrospective cohort study. Addiction 115(8): 1534–1546CrossRef Carney G, Bassett K, Maclure M et al (2020) Cardiovascular and neuropsychiatric safety of smoking cessation pharmacotherapies in non-depressed adults: a retrospective cohort study. Addiction 115(8): 1534–1546CrossRef
Zurück zum Zitat Csajka C, Crettol S, Guidi M, Eap CB (2016) Population genetic-based pharmacokinetic modeling of methadone and its relationship with the QTc interval in opioid-dependent patients. Clin Pharmacokinet 55(12):1521–1533CrossRef Csajka C, Crettol S, Guidi M, Eap CB (2016) Population genetic-based pharmacokinetic modeling of methadone and its relationship with the QTc interval in opioid-dependent patients. Clin Pharmacokinet 55(12):1521–1533CrossRef
Zurück zum Zitat Davies NM, Taylor GMJ, Taylor AE et al (2018) The effects of prescribing varenicline on two-year health outcomes: an observational cohort study using electronic medical records. Addiction 113(6):1105–1116CrossRef Davies NM, Taylor GMJ, Taylor AE et al (2018) The effects of prescribing varenicline on two-year health outcomes: an observational cohort study using electronic medical records. Addiction 113(6):1105–1116CrossRef
Zurück zum Zitat Desai RJ, Good MM, San-Juan-Rodriguez A et al (2019) Varenicline and nicotine replacement use associated with US Food and Drug Administration Drug Safety Communications. JAMA Netw Open 2(9):e1910626CrossRef Desai RJ, Good MM, San-Juan-Rodriguez A et al (2019) Varenicline and nicotine replacement use associated with US Food and Drug Administration Drug Safety Communications. JAMA Netw Open 2(9):e1910626CrossRef
Zurück zum Zitat Doran N, Dubrava S, Anthenelli RM (2019) Effects of varenicline, depressive symptoms, and region of enrollment on smoking cessation in depressed smokers. Nicotine Tob Res 21(2):156–162CrossRef Doran N, Dubrava S, Anthenelli RM (2019) Effects of varenicline, depressive symptoms, and region of enrollment on smoking cessation in depressed smokers. Nicotine Tob Res 21(2):156–162CrossRef
Zurück zum Zitat D’Souza DC, Cortes-Briones J, Creatura G et al (2019) Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial. Lancet Psychiatry 6(1):35–45CrossRef D’Souza DC, Cortes-Briones J, Creatura G et al (2019) Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial. Lancet Psychiatry 6(1):35–45CrossRef
Zurück zum Zitat Evins AE, Benowitz NL, West R et al (2019) Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with psychotic, anxiety, and mood disorders in the EAGLES Trial. J Clin Psychopharmacol 39(2):108–116CrossRef Evins AE, Benowitz NL, West R et al (2019) Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with psychotic, anxiety, and mood disorders in the EAGLES Trial. J Clin Psychopharmacol 39(2):108–116CrossRef
Zurück zum Zitat Falk DE, O’Malley SS, Witkiewitz K et al; Alcohol Clinical Trials Initiative (ACTIVE) Workgroup (2019) Evaluation of drinking risk levels as outcomes in alcohol pharmacotherapy trials: a secondary analysis of 3 randomized clinical trials. Jama Psychiatry 76(4):374–381CrossRef Falk DE, O’Malley SS, Witkiewitz K et al; Alcohol Clinical Trials Initiative (ACTIVE) Workgroup (2019) Evaluation of drinking risk levels as outcomes in alcohol pharmacotherapy trials: a secondary analysis of 3 randomized clinical trials. Jama Psychiatry 76(4):374–381CrossRef
Zurück zum Zitat Gobbi G, Atkin T, Zytynski T et al (2019) Association of cannabis use in adolescence and risk of depression, anxiety, and suicidality in young adulthood. A systematic review and meta-analysis. Jama Psychiatry 76(4):426–434CrossRef Gobbi G, Atkin T, Zytynski T et al (2019) Association of cannabis use in adolescence and risk of depression, anxiety, and suicidality in young adulthood. A systematic review and meta-analysis. Jama Psychiatry 76(4):426–434CrossRef
Zurück zum Zitat Gouzoulis-Mayfrank E, Härtel-Petri R, Hamdorf W et al (2017) Methamphetamine-related disorders. Dtsch Arztebl Int 114(26):455–461PubMedPubMedCentral Gouzoulis-Mayfrank E, Härtel-Petri R, Hamdorf W et al (2017) Methamphetamine-related disorders. Dtsch Arztebl Int 114(26):455–461PubMedPubMedCentral
Zurück zum Zitat Heinzerling KG, Swanson AN, Hall TM et al (2014) Randomized, placebo-controlled trial of bupropion in methamphetamine-dependent participants with less than daily methamphetamine use. Addiction 109(11):1878–1886CrossRef Heinzerling KG, Swanson AN, Hall TM et al (2014) Randomized, placebo-controlled trial of bupropion in methamphetamine-dependent participants with less than daily methamphetamine use. Addiction 109(11):1878–1886CrossRef
Zurück zum Zitat Hoch E, Friemel CM, Schneider M (Hrsg) (2018) Cannabis: Potential und Risiko. Ergebnisse einer wissenschaftlichen Analyse. Springer, Berlin Heidelberg New York Hoch E, Friemel CM, Schneider M (Hrsg) (2018) Cannabis: Potential und Risiko. Ergebnisse einer wissenschaftlichen Analyse. Springer, Berlin Heidelberg New York
Zurück zum Zitat Hohmann N, Mikus G, Czock D (2014) Wirkungen und Risiken neuartiger psychoaktiver Substanzen. Dt Ärztebl 9:139–147 Hohmann N, Mikus G, Czock D (2014) Wirkungen und Risiken neuartiger psychoaktiver Substanzen. Dt Ärztebl 9:139–147
Zurück zum Zitat Kampman KM, Pettinati HM, Lynch KG et al (2013) A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence. Drug Alcohol Depend 133(1):94–99CrossRef Kampman KM, Pettinati HM, Lynch KG et al (2013) A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence. Drug Alcohol Depend 133(1):94–99CrossRef
Zurück zum Zitat Kishi T, Sevy S, Chekuri R, Correll CU (2013) Antipsychotics for primary alcohol dependence: a systematic review and meta-analysis of placebo-controlled trials. Clin Psychiatry 74(7):e642–e654CrossRef Kishi T, Sevy S, Chekuri R, Correll CU (2013) Antipsychotics for primary alcohol dependence: a systematic review and meta-analysis of placebo-controlled trials. Clin Psychiatry 74(7):e642–e654CrossRef
Zurück zum Zitat Levin FR, Mariani J, Brooks DJ et al (2013) A randomized double-blind, placebo controlled trial of venlafaxine-extended release for co-occurring cannabis dependence and depressive disorders. Addiction 108(6):1084–1094CrossRef Levin FR, Mariani J, Brooks DJ et al (2013) A randomized double-blind, placebo controlled trial of venlafaxine-extended release for co-occurring cannabis dependence and depressive disorders. Addiction 108(6):1084–1094CrossRef
Zurück zum Zitat Meier MH, Caspi A, Ambler A et al (2012) Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc Natl Acad Sci USA 109(40):E2657–E2664CrossRef Meier MH, Caspi A, Ambler A et al (2012) Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc Natl Acad Sci USA 109(40):E2657–E2664CrossRef
Zurück zum Zitat Rankin GD, Wingfors H, Uski O et al (2019) The toxic potential of a fourth-generation E-cigarette on human lung cell lines and tissue explants. J Appl Toxicol 39(8):1143–1154CrossRef Rankin GD, Wingfors H, Uski O et al (2019) The toxic potential of a fourth-generation E-cigarette on human lung cell lines and tissue explants. J Appl Toxicol 39(8):1143–1154CrossRef
Zurück zum Zitat Rose JE, Behm FM (2014) Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm. Am J Psychiatry 171(11):1199–1205CrossRef Rose JE, Behm FM (2014) Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm. Am J Psychiatry 171(11):1199–1205CrossRef
Zurück zum Zitat Rüther T, Wissen F, Linhardt A et al (2016) Electronic cigarettes – attitudes and use in Germany. Nicotine Tob Res 18(5):660–669CrossRef Rüther T, Wissen F, Linhardt A et al (2016) Electronic cigarettes – attitudes and use in Germany. Nicotine Tob Res 18(5):660–669CrossRef
Zurück zum Zitat Sigmon SC, Dunn KE, Saulsgiver K et al (2013) A randomized, double-blind evaluation of buprenorphine taper duration in primary prescription opioid abusers. JAMA Psychiatry 70(12):1347–1354CrossRef Sigmon SC, Dunn KE, Saulsgiver K et al (2013) A randomized, double-blind evaluation of buprenorphine taper duration in primary prescription opioid abusers. JAMA Psychiatry 70(12):1347–1354CrossRef
Zurück zum Zitat Simpson TL, Saxon AJ, Stappenbeck C et al (2018) Double-blind randomized clinical trial of prazosin for alcohol use disorder. Am J Psychiatry 175(12):1216–1224CrossRef Simpson TL, Saxon AJ, Stappenbeck C et al (2018) Double-blind randomized clinical trial of prazosin for alcohol use disorder. Am J Psychiatry 175(12):1216–1224CrossRef
Zurück zum Zitat Soyka M (2016) Nalmefene for the treatment of alcohol use disorders: recent data and clinical potential. Expert Opin Pharmacother 17(4):619–626CrossRef Soyka M (2016) Nalmefene for the treatment of alcohol use disorders: recent data and clinical potential. Expert Opin Pharmacother 17(4):619–626CrossRef
Zurück zum Zitat Soyka M, Pogarell O (2019) Neue Slow-release-Buprenorphinformulierungen zur Optimierung der Opioidsubstitution. Nervenarzt 90(9):932–937CrossRef Soyka M, Pogarell O (2019) Neue Slow-release-Buprenorphinformulierungen zur Optimierung der Opioidsubstitution. Nervenarzt 90(9):932–937CrossRef
Zurück zum Zitat Squeglia LM, Tomko RL, Baker NL et al (2018) The effect of N-acetylcysteine on alcohol use during a cannabis cessation trial. Drug Alcohol Depend 185:17–22CrossRef Squeglia LM, Tomko RL, Baker NL et al (2018) The effect of N-acetylcysteine on alcohol use during a cannabis cessation trial. Drug Alcohol Depend 185:17–22CrossRef
Zurück zum Zitat Stapleton J, West R, Hajek P et al (2013) Randomized trial of nicotine replacement therapy (NRT), bupropion and NRT plus bupropion for smoking cessation: effectiveness in clinical practice. Addiction 108(12):2193–2201CrossRef Stapleton J, West R, Hajek P et al (2013) Randomized trial of nicotine replacement therapy (NRT), bupropion and NRT plus bupropion for smoking cessation: effectiveness in clinical practice. Addiction 108(12):2193–2201CrossRef
Zurück zum Zitat Sullivan JT, Sykora K, Schneiderman J et al (1989) Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). Br J Addict 84(11):1353–1357CrossRef Sullivan JT, Sykora K, Schneiderman J et al (1989) Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). Br J Addict 84(11):1353–1357CrossRef
Zurück zum Zitat Verthein U, Beck T, Haasen C, Reimer J (2015) Mental symptoms and drug use in maintenance treatment with slow-release oral morphine compared to methadone: results of a randomized crossover study. Eur Addict Res 21(2):97–104CrossRef Verthein U, Beck T, Haasen C, Reimer J (2015) Mental symptoms and drug use in maintenance treatment with slow-release oral morphine compared to methadone: results of a randomized crossover study. Eur Addict Res 21(2):97–104CrossRef
Metadaten
Titel
Medikamente zur Behandlung von Abhängigkeitserkrankungen und abhängigem Verhalten
verfasst von
Prof. Dr. med. Falk Kiefer
Otto Benkert
Copyright-Jahr
2021
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-61753-3_7