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Erschienen in: coloproctology 3/2022

12.05.2022 | Subtotale Kolektomie | Leitthema

Therapie des Lokalrezidivs beim Kolonkarzinom

verfasst von: Claudia Handtrack, Klaus Weber, Susanne Merkel, Prof. Dr. Robert Grützmann, Axel Denz

Erschienen in: coloproctology | Ausgabe 3/2022

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Zusammenfassung

Durch die konsequente Umsetzung der Kriterien der kompletten mesokolischen Exzision (CME) bei der onkologischen Resektion des Kolonkarzinoms konnten die Lokalrezidivraten bei diesen Tumoren deutlich gesenkt werden. Risikofaktoren für das Auftreten von lokalen Rezidiven sind neben einer inkompletten Resektion des Primärtumors u. a. die Lokalisation, ein lokal oder lymphonodal fortgeschrittenes Karzinom (pT4/pN2), die Operation im Notfall sowie postoperativ aufgetretene Komplikationen, insbesondere eine Anastomoseninsuffizienz. Die Prognose von Patienten mit einem Lokalrezidiv wird entscheidend von der Resektabilität beeinflusst. Ist eine R0-Situation gewährleistet, ggf. nach neoadjuvanter Therapie oder durch Multiviszeralresektion, können 5‑Jahres-Überlebensraten von über 50 % erreicht werden.
Literatur
1.
Zurück zum Zitat Hohenberger W, Weber K, Matzel K, Papadopoulos T, Merkel S (2009) Standardized surgery for colonic cancer: complete mesocolic excision and central ligation—technical notes and outcome. Colorectal Dis 11(4):354–364 (discussion 64–5) PubMed Hohenberger W, Weber K, Matzel K, Papadopoulos T, Merkel S (2009) Standardized surgery for colonic cancer: complete mesocolic excision and central ligation—technical notes and outcome. Colorectal Dis 11(4):354–364 (discussion 64–5) PubMed
2.
Zurück zum Zitat Heald RJ (1998) Total mesorectal excision. The new European gold standard. G Chir 19(6-7):253–255 PubMed Heald RJ (1998) Total mesorectal excision. The new European gold standard. G Chir 19(6-7):253–255 PubMed
3.
Zurück zum Zitat Merkel S, Weber K, Matzel KE, Agaimy A, Gohl J, Hohenberger W (2016) Prognosis of patients with colonic carcinoma before, during and after implementation of complete mesocolic excision. Br J Surg 103(9):1220–1229 PubMed Merkel S, Weber K, Matzel KE, Agaimy A, Gohl J, Hohenberger W (2016) Prognosis of patients with colonic carcinoma before, during and after implementation of complete mesocolic excision. Br J Surg 103(9):1220–1229 PubMed
4.
Zurück zum Zitat German Guideline Program in Oncology, German Cancer Society GCA, AWMF (2020) S3-guideline colorectal cancer, long version 2.1, 2. Aufl. (AWMF, registration number: 021-007OL) German Guideline Program in Oncology, German Cancer Society GCA, AWMF (2020) S3-guideline colorectal cancer, long version 2.1, 2. Aufl. (AWMF, registration number: 021-007OL)
5.
Zurück zum Zitat Moran B, Cunningham C, Singh T, Sagar P, Bradbury J, Geh I et al (2017) Association of coloproctology of Great Britain & Ireland (ACPGBI): guidelines for the management of cancer of the colon, rectum and anus (2017)—surgical management. Colorectal Dis 19(1):18–36 PubMed Moran B, Cunningham C, Singh T, Sagar P, Bradbury J, Geh I et al (2017) Association of coloproctology of Great Britain & Ireland (ACPGBI): guidelines for the management of cancer of the colon, rectum and anus (2017)—surgical management. Colorectal Dis 19(1):18–36 PubMed
6.
Zurück zum Zitat Vogel JD, Eskicioglu C, Weiser MR, Feingold DL, Steele SR (2017) The American society of colon and rectal surgeons clinical practice guidelines for the treatment of colon cancer. Dis Colon Rectum 60(10):999–1017 PubMed Vogel JD, Eskicioglu C, Weiser MR, Feingold DL, Steele SR (2017) The American society of colon and rectal surgeons clinical practice guidelines for the treatment of colon cancer. Dis Colon Rectum 60(10):999–1017 PubMed
7.
Zurück zum Zitat Akiyoshi T, Fujimoto Y, Konishi T, Kuroyanagi H, Ueno M, Oya M et al (2011) Prognostic factors for survival after salvage surgery for locoregional recurrence of colon cancer. Am J Surg 201(6):726–733 PubMed Akiyoshi T, Fujimoto Y, Konishi T, Kuroyanagi H, Ueno M, Oya M et al (2011) Prognostic factors for survival after salvage surgery for locoregional recurrence of colon cancer. Am J Surg 201(6):726–733 PubMed
8.
Zurück zum Zitat Elferink MAG, Visser O, Wiggers T, Otter R, Tollenaar RAEM, Langendijk JA et al (2012) Prognostic factors for locoregional recurrences in colon cancer. Ann Surg Oncol 19(7):2203–2211 PubMed Elferink MAG, Visser O, Wiggers T, Otter R, Tollenaar RAEM, Langendijk JA et al (2012) Prognostic factors for locoregional recurrences in colon cancer. Ann Surg Oncol 19(7):2203–2211 PubMed
9.
Zurück zum Zitat Park JH, Kim MJ, Park SC, Kim MJ, Hong CW, Sohn DK et al (2015) Difference in time to locoregional recurrence between patients with right-sided and left-sided colon cancers. Dis Colon Rectum 58(9):831–837 PubMed Park JH, Kim MJ, Park SC, Kim MJ, Hong CW, Sohn DK et al (2015) Difference in time to locoregional recurrence between patients with right-sided and left-sided colon cancers. Dis Colon Rectum 58(9):831–837 PubMed
10.
Zurück zum Zitat Bowne WB, Lee B, Wong WD, Ben-Porat L, Shia J, Cohen AM et al (2005) Operative salvage for locoregional recurrent colon cancer after curative resection: an analysis of 100 cases. Dis Colon Rectum 48(5):897–909 PubMed Bowne WB, Lee B, Wong WD, Ben-Porat L, Shia J, Cohen AM et al (2005) Operative salvage for locoregional recurrent colon cancer after curative resection: an analysis of 100 cases. Dis Colon Rectum 48(5):897–909 PubMed
11.
Zurück zum Zitat Harji DP, Sagar PM, Boyle K, Griffiths B, McArthur DR, Evans M (2013) Surgical resection of recurrent colonic cancer. Br J Surg 100(7):950–958 PubMed Harji DP, Sagar PM, Boyle K, Griffiths B, McArthur DR, Evans M (2013) Surgical resection of recurrent colonic cancer. Br J Surg 100(7):950–958 PubMed
12.
Zurück zum Zitat Devereux DF, Deckers PJ (1985) Contributions of pathologic margins and Dukes’ stage to local recurrence in colorectal carcinoma. Am J Surg 149(3):323–326 PubMed Devereux DF, Deckers PJ (1985) Contributions of pathologic margins and Dukes’ stage to local recurrence in colorectal carcinoma. Am J Surg 149(3):323–326 PubMed
13.
Zurück zum Zitat Sjovall A, Granath F, Cedermark B, Glimelius B, Holm T (2007) Loco-regional recurrence from colon cancer: a population-based study. Ann Surg Oncol 14(2):432–440 PubMed Sjovall A, Granath F, Cedermark B, Glimelius B, Holm T (2007) Loco-regional recurrence from colon cancer: a population-based study. Ann Surg Oncol 14(2):432–440 PubMed
14.
Zurück zum Zitat Chang GJ, Rodriguez-Bigas MA, Skibber JM, Moyer VA (2007) Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst 99(6):433–441 PubMed Chang GJ, Rodriguez-Bigas MA, Skibber JM, Moyer VA (2007) Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst 99(6):433–441 PubMed
15.
Zurück zum Zitat Le Voyer TE, Sigurdson ER, Hanlon AL, Mayer RJ, Macdonald JS, Catalano PJ et al (2003) Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089. J Clin Oncol 21(15):2912–2919 PubMed Le Voyer TE, Sigurdson ER, Hanlon AL, Mayer RJ, Macdonald JS, Catalano PJ et al (2003) Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089. J Clin Oncol 21(15):2912–2919 PubMed
16.
Zurück zum Zitat Hohenberger P, Schlag P, Kretzschmar U, Herfarth C (1991) Regional mesenteric recurrence of colorectal cancer after anterior resection or left hemicolectomy: inadequate primary resection demonstrated by angiography of the remaining arterial supply. Int J Colorectal Dis 6(1):17–23 PubMed Hohenberger P, Schlag P, Kretzschmar U, Herfarth C (1991) Regional mesenteric recurrence of colorectal cancer after anterior resection or left hemicolectomy: inadequate primary resection demonstrated by angiography of the remaining arterial supply. Int J Colorectal Dis 6(1):17–23 PubMed
17.
Zurück zum Zitat Munkedal DLE, Rosenkilde M, Nielsen DT, Sommer T, West NP, Laurberg S (2017) Radiological and pathological evaluation of the level of arterial division after colon cancer surgery. Colorectal Dis 19(7):O238–O45 PubMed Munkedal DLE, Rosenkilde M, Nielsen DT, Sommer T, West NP, Laurberg S (2017) Radiological and pathological evaluation of the level of arterial division after colon cancer surgery. Colorectal Dis 19(7):O238–O45 PubMed
18.
Zurück zum Zitat Biondo S, Kreisler E, Millan M, Fraccalvieri D, Golda T, Marti Rague J et al (2008) Differences in patient postoperative and long-term outcomes between obstructive and perforated colonic cancer. Am J Surg 195(4):427–432 PubMed Biondo S, Kreisler E, Millan M, Fraccalvieri D, Golda T, Marti Rague J et al (2008) Differences in patient postoperative and long-term outcomes between obstructive and perforated colonic cancer. Am J Surg 195(4):427–432 PubMed
19.
Zurück zum Zitat Manfredi S, Bouvier AM, Lepage C, Hatem C, Dancourt V, Faivre J (2006) Incidence and patterns of recurrence after resection for cure of colonic cancer in a well defined population. Br J Surg 93(9):1115–1122 PubMed Manfredi S, Bouvier AM, Lepage C, Hatem C, Dancourt V, Faivre J (2006) Incidence and patterns of recurrence after resection for cure of colonic cancer in a well defined population. Br J Surg 93(9):1115–1122 PubMed
20.
Zurück zum Zitat Ho YH, Siu SK, Buttner P, Stevenson A, Lumley J, Stitz R (2010) The effect of obstruction and perforation on colorectal cancer disease-free survival. World J Surg 34(5):1091–1101 PubMed Ho YH, Siu SK, Buttner P, Stevenson A, Lumley J, Stitz R (2010) The effect of obstruction and perforation on colorectal cancer disease-free survival. World J Surg 34(5):1091–1101 PubMed
21.
Zurück zum Zitat Biondo S, Marti-Rague J, Kreisler E, Pares D, Martin A, Navarro M et al (2005) A prospective study of outcomes of emergency and elective surgeries for complicated colonic cancer. Am J Surg 189(4):377–383 PubMed Biondo S, Marti-Rague J, Kreisler E, Pares D, Martin A, Navarro M et al (2005) A prospective study of outcomes of emergency and elective surgeries for complicated colonic cancer. Am J Surg 189(4):377–383 PubMed
22.
Zurück zum Zitat Biondo S, Galvez A, Ramirez E, Frago R, Kreisler E (2019) Emergency surgery for obstructing and perforated colon cancer: patterns of recurrence and prognostic factors. Tech Coloproctol 23(12):1141–1161 PubMed Biondo S, Galvez A, Ramirez E, Frago R, Kreisler E (2019) Emergency surgery for obstructing and perforated colon cancer: patterns of recurrence and prognostic factors. Tech Coloproctol 23(12):1141–1161 PubMed
23.
Zurück zum Zitat Artinyan A, Orcutt ST, Anaya DA, Richardson P, Chen GJ, Berger DH (2015) Infectious postoperative complications decrease long-term survival in patients undergoing curative surgery for colorectal cancer: a study of 12,075 patients. Ann Surg 261(3):497–505 PubMed Artinyan A, Orcutt ST, Anaya DA, Richardson P, Chen GJ, Berger DH (2015) Infectious postoperative complications decrease long-term survival in patients undergoing curative surgery for colorectal cancer: a study of 12,075 patients. Ann Surg 261(3):497–505 PubMed
24.
Zurück zum Zitat Mirnezami A, Mirnezami R, Chandrakumaran K, Sasapu K, Sagar P, Finan P (2011) Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysis. Ann Surg 253(5):890–899 PubMed Mirnezami A, Mirnezami R, Chandrakumaran K, Sasapu K, Sagar P, Finan P (2011) Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysis. Ann Surg 253(5):890–899 PubMed
25.
Zurück zum Zitat Merkel S, Wang WY, Schmidt O, Dworak O, Wittekind C, Hohenberger W et al (2001) Locoregional recurrence in patients with anastomotic leakage after anterior resection for rectal carcinoma. Colorectal Dis 3(3):154–160 PubMed Merkel S, Wang WY, Schmidt O, Dworak O, Wittekind C, Hohenberger W et al (2001) Locoregional recurrence in patients with anastomotic leakage after anterior resection for rectal carcinoma. Colorectal Dis 3(3):154–160 PubMed
26.
Zurück zum Zitat Wang S, Liu J, Wang S, Zhao H, Ge S, Wang W (2017) Adverse effects of anastomotic leakage on local recurrence and survival after curative anterior resection for rectal cancer: a systematic review and meta-analysis. World J Surg 41(1):277–284 PubMed Wang S, Liu J, Wang S, Zhao H, Ge S, Wang W (2017) Adverse effects of anastomotic leakage on local recurrence and survival after curative anterior resection for rectal cancer: a systematic review and meta-analysis. World J Surg 41(1):277–284 PubMed
27.
Zurück zum Zitat Beck C, Weber K, Brunner M, Agaimy A, Semrau S, Grutzmann R et al (2020) The influence of postoperative complications on long-term prognosis in patients with colorectal carcinoma. Int J Colorectal Dis 35(6):1055–1066 PubMedPubMedCentral Beck C, Weber K, Brunner M, Agaimy A, Semrau S, Grutzmann R et al (2020) The influence of postoperative complications on long-term prognosis in patients with colorectal carcinoma. Int J Colorectal Dis 35(6):1055–1066 PubMedPubMedCentral
28.
Zurück zum Zitat Obrand DI, Gordon PH (1997) Incidence and patterns of recurrence following curative resection for colorectal carcinoma. Dis Colon Rectum 40(1):15–24 PubMed Obrand DI, Gordon PH (1997) Incidence and patterns of recurrence following curative resection for colorectal carcinoma. Dis Colon Rectum 40(1):15–24 PubMed
29.
Zurück zum Zitat Harris GJC, Church JM, Senagore AJ, Lavery IC, Hull TL, Strong SA et al (2002) Factors affecting local recurrence of colonic adenocarcinoma. Dis Colon Rectum 45(8):1029–1034 PubMed Harris GJC, Church JM, Senagore AJ, Lavery IC, Hull TL, Strong SA et al (2002) Factors affecting local recurrence of colonic adenocarcinoma. Dis Colon Rectum 45(8):1029–1034 PubMed
30.
Zurück zum Zitat Nozawa H, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K et al (2015) Large colorectal carcinoma is predictive of recurrence after adjuvant chemotherapy using oxaliplatin. Anticancer Res 35(9):5073–5078 PubMed Nozawa H, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K et al (2015) Large colorectal carcinoma is predictive of recurrence after adjuvant chemotherapy using oxaliplatin. Anticancer Res 35(9):5073–5078 PubMed
31.
Zurück zum Zitat Green BL, Marshall HC, Collinson F, Quirke P, Guillou P, Jayne DG et al (2013) Long-term follow-up of the medical research council CLASICC trial of conventional versus laparoscopically assisted resection in colorectal cancer. Br J Surg 100(1):75–82 PubMed Green BL, Marshall HC, Collinson F, Quirke P, Guillou P, Jayne DG et al (2013) Long-term follow-up of the medical research council CLASICC trial of conventional versus laparoscopically assisted resection in colorectal cancer. Br J Surg 100(1):75–82 PubMed
32.
Zurück zum Zitat Meguid RA, Slidell MB, Wolfgang CL, Chang DC, Ahuja N (2008) Is there a difference in survival between right- versus left-sided colon cancers? Ann Surg Oncol 15(9):2388–2394 PubMedPubMedCentral Meguid RA, Slidell MB, Wolfgang CL, Chang DC, Ahuja N (2008) Is there a difference in survival between right- versus left-sided colon cancers? Ann Surg Oncol 15(9):2388–2394 PubMedPubMedCentral
33.
Zurück zum Zitat Yamauchi M, Morikawa T, Kuchiba A, Imamura Y, Qian ZR, Nishihara R et al (2012) Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 61(6):847–854 PubMed Yamauchi M, Morikawa T, Kuchiba A, Imamura Y, Qian ZR, Nishihara R et al (2012) Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 61(6):847–854 PubMed
34.
Zurück zum Zitat Missiaglia E, Jacobs B, D’Ario G, Di Narzo AF, Soneson C, Budinska E et al (2014) Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features. Ann Oncol 25(10):1995–2001 PubMed Missiaglia E, Jacobs B, D’Ario G, Di Narzo AF, Soneson C, Budinska E et al (2014) Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features. Ann Oncol 25(10):1995–2001 PubMed
35.
Zurück zum Zitat Weber K, Merkel S, Perrakis A, Hohenberger W (2013) Is there a disadvantage to radical lymph node dissection in colon cancer? Int J Colorectal Dis 28(2):217–226 PubMed Weber K, Merkel S, Perrakis A, Hohenberger W (2013) Is there a disadvantage to radical lymph node dissection in colon cancer? Int J Colorectal Dis 28(2):217–226 PubMed
36.
Zurück zum Zitat Liska D, Stocchi L, Karagkounis G, Elagili F, Dietz DW, Kalady MF et al (2017) Incidence, patterns, and predictors of locoregional recurrence in colon cancer. Ann Surg Oncol 24(4):1093–1099 PubMed Liska D, Stocchi L, Karagkounis G, Elagili F, Dietz DW, Kalady MF et al (2017) Incidence, patterns, and predictors of locoregional recurrence in colon cancer. Ann Surg Oncol 24(4):1093–1099 PubMed
37.
Zurück zum Zitat Read TE, Mutch MG, Chang BW, McNevin MS, Fleshman JW, Birnbaum EH et al (2002) Locoregional recurrence and survival after curative resection of adenocarcinoma of the colon. J Am Coll Surg 195(1):33–40 PubMed Read TE, Mutch MG, Chang BW, McNevin MS, Fleshman JW, Birnbaum EH et al (2002) Locoregional recurrence and survival after curative resection of adenocarcinoma of the colon. J Am Coll Surg 195(1):33–40 PubMed
38.
Zurück zum Zitat Yun HR, Lee LJ, Park JH, Cho YK, Cho YB, Lee WY et al (2008) Local recurrence after curative resection in patients with colon and rectal cancers. Int J Colorectal Dis 23(11):1081–1087 PubMed Yun HR, Lee LJ, Park JH, Cho YK, Cho YB, Lee WY et al (2008) Local recurrence after curative resection in patients with colon and rectal cancers. Int J Colorectal Dis 23(11):1081–1087 PubMed
39.
Zurück zum Zitat Hohenberger W, Lux P, Merkel S, Weber K (2011) Lymph node dissection for carcinomas of the lower gastrointestinal tract. What is evidence-based? Chirurg 82(12):1096–1105 PubMed Hohenberger W, Lux P, Merkel S, Weber K (2011) Lymph node dissection for carcinomas of the lower gastrointestinal tract. What is evidence-based? Chirurg 82(12):1096–1105 PubMed
40.
Zurück zum Zitat Pita-Fernandez S, Alhayek-Ai M, Gonzalez-Martin C, Lopez-Calvino B, Seoane-Pillado T, Pertega-Diaz S (2015) Intensive follow-up strategies improve outcomes in nonmetastatic colorectal cancer patients after curative surgery: a systematic review and meta-analysis. Ann Oncol 26(4):644–656 PubMed Pita-Fernandez S, Alhayek-Ai M, Gonzalez-Martin C, Lopez-Calvino B, Seoane-Pillado T, Pertega-Diaz S (2015) Intensive follow-up strategies improve outcomes in nonmetastatic colorectal cancer patients after curative surgery: a systematic review and meta-analysis. Ann Oncol 26(4):644–656 PubMed
41.
Zurück zum Zitat Goldberg RM, Fleming TR, Tangen CM, Moertel CG, Macdonald JS, Haller DG et al (1998) Surgery for recurrent colon cancer: strategies for identifying resectable recurrence and success rates after resection. Eastern cooperative oncology group, the north central cancer treatment group, and the southwest oncology group. Ann Intern Med 129(1):27–35 PubMed Goldberg RM, Fleming TR, Tangen CM, Moertel CG, Macdonald JS, Haller DG et al (1998) Surgery for recurrent colon cancer: strategies for identifying resectable recurrence and success rates after resection. Eastern cooperative oncology group, the north central cancer treatment group, and the southwest oncology group. Ann Intern Med 129(1):27–35 PubMed
42.
Zurück zum Zitat Moritani K, Hasegawa H, Okabayashi K, Ishii Y, Endo T, Kitagawa Y (2014) Difference in the recurrence rate between right- and left-sided colon cancer: a 17-year experience at a single institution. Surg Today 44(9):1685–1691 PubMed Moritani K, Hasegawa H, Okabayashi K, Ishii Y, Endo T, Kitagawa Y (2014) Difference in the recurrence rate between right- and left-sided colon cancer: a 17-year experience at a single institution. Surg Today 44(9):1685–1691 PubMed
43.
Zurück zum Zitat Taylor WE, Donohue JH, Gunderson LL, Nelson H, Nagorney DM, Devine RM et al (2002) The Mayo Clinic experience with multimodality treatment of locally advanced or recurrent colon cancer. Ann Surg Oncol 9(2):177–185 PubMed Taylor WE, Donohue JH, Gunderson LL, Nelson H, Nagorney DM, Devine RM et al (2002) The Mayo Clinic experience with multimodality treatment of locally advanced or recurrent colon cancer. Ann Surg Oncol 9(2):177–185 PubMed
44.
Zurück zum Zitat Watanabe T, Muro K, Ajioka Y, Hashiguchi Y, Ito Y, Saito Y et al (2018) Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer. Int J Clin Oncol 23(1):1–34 PubMed Watanabe T, Muro K, Ajioka Y, Hashiguchi Y, Ito Y, Saito Y et al (2018) Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer. Int J Clin Oncol 23(1):1–34 PubMed
45.
Zurück zum Zitat Chesney TR, Nadler A, Acuna SA, Swallow CJ (2016) Outcomes of resection for locoregionally recurrent colon cancer: a systematic review. Surgery 160(1):54–66 PubMed Chesney TR, Nadler A, Acuna SA, Swallow CJ (2016) Outcomes of resection for locoregionally recurrent colon cancer: a systematic review. Surgery 160(1):54–66 PubMed
Metadaten
Titel
Therapie des Lokalrezidivs beim Kolonkarzinom
verfasst von
Claudia Handtrack
Klaus Weber
Susanne Merkel
Prof. Dr. Robert Grützmann
Axel Denz
Publikationsdatum
12.05.2022
Verlag
Springer Medizin
Erschienen in
coloproctology / Ausgabe 3/2022
Print ISSN: 0174-2442
Elektronische ISSN: 1615-6730
DOI
https://doi.org/10.1007/s00053-022-00608-x

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