Erschienen in:
07.08.2017 | Letter to the Editor
Successful Roux-en-Y Gastric Bypass in a Patient with McArdle Disease
verfasst von:
Meredith Ross, Whitney Goldner
Erschienen in:
Obesity Surgery
|
Ausgabe 10/2017
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Excerpt
We report a 44-year-old female with McArdle disease, a rare metabolic muscle disorder, and morbid obesity (BMI 46 kg/m, weight 128.2 kg) who successfully underwent Roux-en-Y gastric bypass. McArdle disease is the most common glycogen storage disease, and it is characterized by the lack of myophosphorylase, the enzyme that converts glycogen to glucose within the muscle. Without a consistent intake of simple sugars, patients with McArdle disease are at risk of developing rhabdomyolysis. Rhabdomyolysis is caused by the destruction of muscle cells and can present as myalgias, fatigue, and acute renal failure. It is diagnosed by elevated creatinine kinase (CK) and myoglobinuria. Rhabdomyolysis is most common in patients with McArdle disease following strenuous exercise due to the lack of anaerobic glycogenolysis in the muscle. [
1]. …
