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Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in vivo by 300–700 fold has been intensely investigated.
Keratoacanthoma in an 86-year-old patient was treated with intralesional bleomycin combined with electroporation. Treatment consisted of local application of shorty and intense electric pulses followed by local injection of bleomycin. Electroporation was always well tolerated by the patient, with no significant complaints, and the tumor had completely regressed by day 71 of the follow-up.
The results suggest that intralesional bleomycin injection combined with electroporation could represent a valid alternative therapeutic approach for the treatment of keratoacanthomas.
Spugnini EP, Pizzuto M, Filipponi M, Romani L, Vincenzi B, Menicagli F, Lanza A, De Girolamo R, Lomonaco R, Fanciulli M, Spriano G, Baldi A. Electroporatio enhances bleomycin efficacy in cats with periocular carcinoma and advanced squamous cell carcinoma of the head. J Vet Intern Med. 2015;29:1368–75. CrossRefPubMedPubMedCentral
Sersa G. The state-of-the-art of electrochemotherapy before the ESOPE study: advantages and clinical use. Eur J Cancer Suppl. 2006;4:52–9. CrossRef
Campana LG, Testori A, Curatolo P, Quaglino P, Mocellin S, Framarini M, Borgognoni L, Ascierto PA, Mozzillo N, Guida M, Bucher S, Rotunno R, Marenco F, De Salvo GL, De Paoli A, Rossi CR, Bonadies A. Treatment efficacy with electrochemotherapy: a multi-institutional prospective observational study on 376 patients with superficial tumors. Eur J Surg Oncol. 2016;42:1914–23. CrossRefPubMed
- Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report
Enrico P. Spugnini
- Springer Healthcare
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