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Erschienen in: Strahlentherapie und Onkologie 8/2017

25.04.2017 | Case Study

Successful treatment of a rare case of ameloblastic fibrosarcoma with radiation therapy

verfasst von: Michael Oertel, MD, Gabriele Reinartz, MD, Sergiu Scobioala, MD, Prof. Hans Theodor Eich, MD

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 8/2017

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Abstract

Sarcomas are rare diseases of the head and neck region, representing around 1% of all malignancies. Amongst them, ameloblastic fibrosarcoma (AFS) is of even greater rarity, with less than 100 cases reported in the literature. Consequently, no standard treatment or guidelines have been made available. Surgery is often performed as primary therapy, but may be limited due to anatomical or functional reasons. We present a case of AFS successfully treated by postoperative radiation therapy. A detailed case study is provided, followed by a review of the English-language literature focusing on the role of radiation therapy.
Literatur
1.
Zurück zum Zitat Gorsky M, Epstein JB (1998) Head and neck and intra-oral soft tissue sarcomas. Oral Oncol 34:292–296CrossRefPubMed Gorsky M, Epstein JB (1998) Head and neck and intra-oral soft tissue sarcomas. Oral Oncol 34:292–296CrossRefPubMed
3.
Zurück zum Zitat Rajendran A, Sundaram S (2012) Shafer’s textbook of oral pathology Rajendran A, Sundaram S (2012) Shafer’s textbook of oral pathology
4.
Zurück zum Zitat Cina MT, Dahlin DC, Gores RJ (1962) Ameloblastic sarcoma. Report of two cases. Oral Surg Oral Med Oral Pathol 15:696–700CrossRefPubMed Cina MT, Dahlin DC, Gores RJ (1962) Ameloblastic sarcoma. Report of two cases. Oral Surg Oral Med Oral Pathol 15:696–700CrossRefPubMed
5.
Zurück zum Zitat de Nogueira TO, Carvalho YR, Rosa LE, Dos Santos LM (1997) Possible malignant transformation of an ameloblastic fibroma to ameloblastic fibrosarcoma: a case report. J Oral Maxillofac Surg 55:180–182CrossRef de Nogueira TO, Carvalho YR, Rosa LE, Dos Santos LM (1997) Possible malignant transformation of an ameloblastic fibroma to ameloblastic fibrosarcoma: a case report. J Oral Maxillofac Surg 55:180–182CrossRef
7.
Zurück zum Zitat Hayashi Y, Tohnai I, Ueda M, Nagasaka T (1999) Sarcomatous overgrowth in recurrent ameloblastic fibrosarcoma. Oral Oncol 35:346–348CrossRefPubMed Hayashi Y, Tohnai I, Ueda M, Nagasaka T (1999) Sarcomatous overgrowth in recurrent ameloblastic fibrosarcoma. Oral Oncol 35:346–348CrossRefPubMed
9.
Zurück zum Zitat Reichart PA, Zobl H (1978) Transformation of ameloblastic fibroma to fibrosarcoma. Int J Oral Surg 7:503–507CrossRefPubMed Reichart PA, Zobl H (1978) Transformation of ameloblastic fibroma to fibrosarcoma. Int J Oral Surg 7:503–507CrossRefPubMed
10.
Zurück zum Zitat Williams MD, Hanna EY, El-Naggar AK (2007) Anaplastic ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma: restricted molecular abnormalities of certain genes to the malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:72–75. doi:10.1016/j.tripleo.2006.07.013 CrossRefPubMed Williams MD, Hanna EY, El-Naggar AK (2007) Anaplastic ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma: restricted molecular abnormalities of certain genes to the malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:72–75. doi:10.​1016/​j.​tripleo.​2006.​07.​013 CrossRefPubMed
15.
16.
Zurück zum Zitat Hatzifotiadis D, Economou A (1973) Ameloblastic sarcoma in the maxilla – a case report. J Maxillofac Surg 1:62–64CrossRefPubMed Hatzifotiadis D, Economou A (1973) Ameloblastic sarcoma in the maxilla – a case report. J Maxillofac Surg 1:62–64CrossRefPubMed
17.
Zurück zum Zitat Adekeye EO, Edwards MB, Goubran GF (1978) Ameloblastic fibrosarcoma. Report of a case in a Nigeria. Oral Surg Oral Med Oral Pathol 46:254–259CrossRefPubMed Adekeye EO, Edwards MB, Goubran GF (1978) Ameloblastic fibrosarcoma. Report of a case in a Nigeria. Oral Surg Oral Med Oral Pathol 46:254–259CrossRefPubMed
18.
Zurück zum Zitat Bregni RC, Taylor AM, García AM (2001) Ameloblastic fibrosarcoma of the mandible: report of two cases and review of the literature. J Oral Pathol Med 30:316–320CrossRefPubMed Bregni RC, Taylor AM, García AM (2001) Ameloblastic fibrosarcoma of the mandible: report of two cases and review of the literature. J Oral Pathol Med 30:316–320CrossRefPubMed
19.
Zurück zum Zitat DeNittis AS, Stambaugh MD, Looby C (1998) Ameloblastic fibrosarcoma of the maxilla: report of a case. J Oral Maxillofac Surg 56:672–675CrossRefPubMed DeNittis AS, Stambaugh MD, Looby C (1998) Ameloblastic fibrosarcoma of the maxilla: report of a case. J Oral Maxillofac Surg 56:672–675CrossRefPubMed
20.
Zurück zum Zitat Goldstein G, Parker FP, Hugh GS (1976) Ameloblastic sarcoma: pathogenesis and treatment with chemotherapy. Cancer 37:1673–1678CrossRefPubMed Goldstein G, Parker FP, Hugh GS (1976) Ameloblastic sarcoma: pathogenesis and treatment with chemotherapy. Cancer 37:1673–1678CrossRefPubMed
21.
Zurück zum Zitat Cataldo E, Nathanson N, Shklar G (1963) Ameloblastic sarcoma of the mandible. Oral Surg Oral Med Oral Pathol 16:953–957CrossRefPubMed Cataldo E, Nathanson N, Shklar G (1963) Ameloblastic sarcoma of the mandible. Oral Surg Oral Med Oral Pathol 16:953–957CrossRefPubMed
22.
Zurück zum Zitat Pindborg JJ (1960) Ameloblastic sarcoma in the maxilla. Report of a case. Cancer 13:917–920CrossRefPubMed Pindborg JJ (1960) Ameloblastic sarcoma in the maxilla. Report of a case. Cancer 13:917–920CrossRefPubMed
23.
Zurück zum Zitat Takeda Y, Kaneko R, Suzuki A (1984) Ameloblastic fibrosarcoma in the maxilla, malignant transformation of ameloblastic fibroma. Virchows Arch A Pathol Anat Histopathol 404:253–263CrossRefPubMed Takeda Y, Kaneko R, Suzuki A (1984) Ameloblastic fibrosarcoma in the maxilla, malignant transformation of ameloblastic fibroma. Virchows Arch A Pathol Anat Histopathol 404:253–263CrossRefPubMed
24.
Zurück zum Zitat Muller S, Parker DC, Kapadia SB et al (1995) Ameloblastic fibrosarcoma of the jaws. A clinicopathologic and DNA analysis of five cases and review of the literature with discussion of its relationship to ameloblastic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79:469–477CrossRefPubMed Muller S, Parker DC, Kapadia SB et al (1995) Ameloblastic fibrosarcoma of the jaws. A clinicopathologic and DNA analysis of five cases and review of the literature with discussion of its relationship to ameloblastic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79:469–477CrossRefPubMed
25.
Zurück zum Zitat Tajima Y, Utsumi N, Suzuki S et al (1997) Ameloblastic fibrosarcoma arising de novo in the maxilla. Pathol Int 47:564–568CrossRefPubMed Tajima Y, Utsumi N, Suzuki S et al (1997) Ameloblastic fibrosarcoma arising de novo in the maxilla. Pathol Int 47:564–568CrossRefPubMed
26.
Zurück zum Zitat Altini M, Thompson SH, Lownie JF, Berezowski BB (1985) Ameloblastic sarcoma of the mandible. J Oral Maxillofac Surg 43:789–794CrossRefPubMed Altini M, Thompson SH, Lownie JF, Berezowski BB (1985) Ameloblastic sarcoma of the mandible. J Oral Maxillofac Surg 43:789–794CrossRefPubMed
27.
29.
Zurück zum Zitat Gregoire V, Mackie TR (2011) Dose prescription, reporting and recording in intensity-modulated radiation therapy: a digest of the ICRU Report 83. Imaging Med 3:367–373. doi:10.2217/iim.11.22 CrossRef Gregoire V, Mackie TR (2011) Dose prescription, reporting and recording in intensity-modulated radiation therapy: a digest of the ICRU Report 83. Imaging Med 3:367–373. doi:10.​2217/​iim.​11.​22 CrossRef
32.
Zurück zum Zitat Looser KG, Kuehn PG (1976) Primary tumors of the mandible. A study of 49 cases. Am J Surg 132:608–614CrossRefPubMed Looser KG, Kuehn PG (1976) Primary tumors of the mandible. A study of 49 cases. Am J Surg 132:608–614CrossRefPubMed
33.
Zurück zum Zitat Stambaugh MD, DeNittis AS (1998) Out of radiation field recurrence of an ameloblastic sarcoma of the maxilla. J Oral Maxillofac Surg 56:1364CrossRefPubMed Stambaugh MD, DeNittis AS (1998) Out of radiation field recurrence of an ameloblastic sarcoma of the maxilla. J Oral Maxillofac Surg 56:1364CrossRefPubMed
34.
35.
36.
Zurück zum Zitat Verweij J, van Oosterom A, Blay J‑Y et al (2003) Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study. Eur J Cancer 39:2006–2011CrossRefPubMed Verweij J, van Oosterom A, Blay J‑Y et al (2003) Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study. Eur J Cancer 39:2006–2011CrossRefPubMed
37.
Zurück zum Zitat Tribius S, Raguse M, Voigt C et al (2015) Residual deficits in quality of life one year after intensity-modulated radiotherapy for patients with locally advanced head and neck cancer: results of a prospective study. Strahlenther Onkol 191:501–510. doi:10.1007/s00066-015-0824-4 CrossRefPubMed Tribius S, Raguse M, Voigt C et al (2015) Residual deficits in quality of life one year after intensity-modulated radiotherapy for patients with locally advanced head and neck cancer: results of a prospective study. Strahlenther Onkol 191:501–510. doi:10.​1007/​s00066-015-0824-4 CrossRefPubMed
Metadaten
Titel
Successful treatment of a rare case of ameloblastic fibrosarcoma with radiation therapy
verfasst von
Michael Oertel, MD
Gabriele Reinartz, MD
Sergiu Scobioala, MD
Prof. Hans Theodor Eich, MD
Publikationsdatum
25.04.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Strahlentherapie und Onkologie / Ausgabe 8/2017
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-017-1136-7

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