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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

14.05.2021 | Brief Report

Successful use of azithromycin for Escherichia coli–associated renal allograft malakoplakia: a report of two cases

verfasst von: Paul M. Kinsella, Olivia C. Smibert, John B. Whitlam, Mark Steven, Ricard Masia, Ronak G. Gandhi, Camille N. Kotton, Natasha E. Holmes

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 12/2021

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Abstract

Malakoplakia is a chronic granulomatous disease associated with incomplete clearance of bacterial pathogens. A multimodal approach to therapy includes antimicrobials with intracellular activity, reduction in immunosuppression, and debulking of lesions. Azithromycin has an intracellular mechanism of action and enhanced Gram-negative activity compared to other macrolides. Despite some in vitro data to support its use, there are no clinical breakpoints or epidemiological cut-off values for most Enterobacterales from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) or the Clinical and Laboratory Standards Institute (CLSI). We present two cases, previously unreported, of Escherichia coli associated renal allograft malakoplakia successfully treated with azithromycin.

Bertrand D, Chavarot N, Gatault P, Garrouste C, Bouvier N, Grall-Jezequel A, Jaureguy M, Caillard S, Lemoine M, Colosio C, Golbin L, Rerolle J-P, Thierry A, Sayegh J, Etienne I, Lebourg L, Sberro R, Guerrot D (2020) Opportunistic infections after conversion to belatacept in kidney transplantation. Nephrol Dial Transplant 35(2):336–345. https://doi.org/10.1093/ndt/gfz255CrossRefPubMed

Blair JEJ, MacLennan GT (2005) Malakoplakia. J Urol 173(3):986–986. https://doi.org/10.1097/01.ju.0000153740.91749.acCrossRefPubMed

Evans NL, French J, Rose MB (1998) Renal malacoplakia: an important consideration in the differential diagnosis of renal masses in the presence of Escherichia coli infection. Br J Radiol 71(850):1083–1085. https://doi.org/10.1259/bjr.71.850.10211070CrossRefPubMed

Fitzgibbons PL (2018) Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders. Semin Diagn Pathol 35(6):370–380. https://doi.org/10.1053/j.semdp.2018.10.002CrossRefPubMed

Goel D, Pradhan D, Tiwary A (2018) Fluorodeoxyglucose avid malakoplakia of the laryngohypopharynx masquerading as malignant tumor: a pathological enigma and clinical dilemma. Indian J Pathol Microbiol 61(2):298. https://doi.org/10.4103/IJPM.IJPM_156_17CrossRefPubMed

Gomes C, Ruiz-Roldán L, Mateu J, Ochoa TJ, Ruiz J (2019) Azithromycin resistance levels and mechanisms in Escherichia coli. Sci Rep 9. https://doi.org/10.1038/s41598-019-42423-3

Köksal D, Ozcan A, Demirağ F, Akman B, Acar LN, Gülhan E, Özmen Ö (2014) Pulmonary malakoplakia: a case report and review of the literature. Tuberk Toraks 62(3):248–252CrossRef

Lococo F, Montanari G, Mengoli MC, Ferrari F, Spagnolo P, Rossi G (2015) Hemoptysis and progressive dyspnea in a 67-year-old woman with history of renal transplantation. Am J Respir Crit Care Med 193(6):e12–e13. https://doi.org/10.1164/rccm.201511-2134IMCrossRef

Matzneller P, Krasniqi S, Kinzig M, Sörgel F, Hüttner S, Lackner E, Müller M, Zeitlinger M (2013) Blood, tissue, and intracellular concentrations of azithromycin during and after end of therapy. Antimicrob Agents Chemother 57(4):1736–1742. https://doi.org/10.1128/AAC.02011-12CrossRefPubMedPubMedCentral

10.

Mookerji N, Skinner T, McAlpine K, Warren J (2019) Case – Malakoplakia in a 58-year-old male following living donor renal transplantation. Can Urol Assoc J 13(1):E19–E21. https://doi.org/10.5489/cuaj.5282CrossRef

11.

Nieto-Ríos JF, Ramírez I, Zuluaga-Quintero M, Serna-Higuita LM, Gaviria-Gil F, Velez-Hoyos A (2017) Malakoplakia after kidney transplantation: Case report and literature review. Transpl Infect Dis 19(5):e12731. https://doi.org/10.1111/tid.12731CrossRef

12.

Parnham MJ, Erakovic Haber V, Giamarellos-Bourboulis EJ, Perletti G, Verleden GM, Vos R (2014) Azithromycin: mechanisms of action and their relevance for clinical applications. Pharmacol Ther 143(2):225–245. https://doi.org/10.1016/j.pharmthera.2014.03.003CrossRefPubMed

13.

Renna M, Schaffner C, Brown K, Shang S, Tamayo MH, Hegyi K, Grimsey NJ, Cusens D, Coulter S, Cooper J, Bowden AR, Newton SM, Kampmann B, Helm J, Jones A, Haworth CS, Basaraba RJ, DeGroote MA, Ordway DJ, Rubinsztein DC, Floto RA (2011) Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection. J Clin Invest 121(9):3554–3563. https://doi.org/10.1172/JCI46095CrossRefPubMedPubMedCentral

14.

Tulpule MS, Bharatia PR, Pradhan AM, Tawade YV (2017) Cutaneous malakoplakia: interesting case report and review of literature. Indian Journal of Dermatology, Venereology, and Leprology 83(5):584. https://doi.org/10.4103/ijdvl.IJDVL_145_17

15.

Yousef GM, Naghibi B (2007) Malakoplakia outside the urinary tract. Arch Pathol Lab Med 131(2):297–300. https://doi.org/10.1043/1543-2165(2007)131[297:MOTUT]2.0.CO;2CrossRefPubMed

16.

Zimmermann P, Ziesenitz VC, Curtis N, Ritz N (2018) The immunomodulatory effects of macrolides—a systematic review of the underlying mechanisms. Front Immunol 9. https://doi.org/10.3389/fimmu.2018.00302

Titel: Successful use of azithromycin for Escherichia coli–associated renal allograft malakoplakia: a report of two cases
verfasst von: Paul M. Kinsella
Olivia C. Smibert
John B. Whitlam
Mark Steven
Ricard Masia
Ronak G. Gandhi
Camille N. Kotton
Natasha E. Holmes
Publikationsdatum: 14.05.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 12/2021
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-021-04270-x

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Successful use of azithromycin for Escherichia coli–associated renal allograft malakoplakia: a report of two cases

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