The online version of this article (doi:10.1186/cc10367) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
SM had full access to all of the data in the study and takes responsibility for the integrity of the data, and the accuracy of the data analysis. SM was a principal investigator, and conceived and designed the trial and developed the protocol and the statistical analysis plan, participated in the recruitment of patients and performed or supervised intubations and drafted the manuscript. HP and MSie were principal investigators, conceived and designed the trial and developed the protocol and the statistical analysis plan, participated in the recruitment of patients and performed or supervised intubations. PH conceived and designed the trial and developed the protocol and the statistical analysis plan and reviewed the safety data. LS, EB, MSch and TA participated in the recruitment of patients and performed or supervised intubations. All authors read and approved the final manuscript.
Succinylcholine and rocuronium are widely used to facilitate rapid sequence induction (RSI) intubation in intensive care. Concerns relate to the side effects of succinylcholine and to slower onset and inferior intubation conditions associated with rocuronium. So far, succinylcholine and rocuronium have not been compared in an adequately powered randomized trial in intensive care. Accordingly, the aim of the present study was to compare the incidence of hypoxemia after rocuronium or succinylcholine in critically ill patients requiring an emergent RSI.
This was a prospective randomized controlled single-blind trial conducted from 2006 to 2010 at the University Hospital of Basel. Participants were 401 critically ill patients requiring emergent RSI. Patients were randomized to receive 1 mg/kg succinylcholine or 0.6 mg/kg rocuronium for neuromuscular blockade. The primary outcome was the incidence of oxygen desaturations defined as a decrease in oxygen saturation ≥ 5%, assessed by continuous pulse oxymetry, at any time between the start of the induction sequence and two minutes after the completion of the intubation. A severe oxygen desaturation was defined as a decrease in oxygen saturation ≥ 5% leading to a saturation value of ≤ 80%.
There was no difference between succinylcholine and rocuronium regarding oxygen desaturations (succinylcholine 73/196; rocuronium 66/195; P = 0.67); severe oxygen desaturations (succinylcholine 20/196; rocuronium 20/195; P = 1.0); and extent of oxygen desaturations (succinylcholine -14 ± 12%; rocuronium -16 ± 13%; P = 0.77). The duration of the intubation sequence was shorter after succinycholine than after rocuronium (81 ± 38 sec versus 95 ± 48 sec; P = 0.002). Intubation conditions (succinylcholine 8.3 ± 0.8; rocuronium 8.2 ± 0.9; P = 0.7) and failed first intubation attempts (succinylcholine 32/200; rocuronium 36/201; P = 1.0) did not differ between the groups.
In critically ill patients undergoing emergent RSI, incidence and severity of oxygen desaturations, the quality of intubation conditions, and incidence of failed intubation attempts did not differ between succinylcholine and rocuronium.
ClinicalTrials.gov, number NCT00355368.
Additional file 1: Checklist of preparations to be performed prior to RSI. (DOC 31 KB)13054_2011_9623_MOESM1_ESM.DOC
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- Succinylcholine versus rocuronium for rapid sequence intubation in intensive care: a prospective, randomized controlled trial
Stephan C Marsch
Patrick R Hunziker
- BioMed Central
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