The online version of this article (doi:10.1186/1471-2261-14-140) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
FH carried the acquisition of data, has been involved in analysis and interpretation of data and in the drafting the manuscript. FF participated in the design of the study and has been involved in drafting and revising of the manuscript. JS has been involved in analysis and interpretation of data and revised the manuscript critically for important intellectual content. KM participated in the design of the study, participated and coordinated the data acquisition, and helped to draft the manuscript and in to its revision. All authors have read and approved the final manuscript.
Sudden cardiac death (SCD) among the young is a rare and devastating event, but its exact incidence in many countries remains unknown. An autopsy is recommended in every case because some of the cardiac pathologies may have a genetic origin, which can have an impact on the living family members. The aims of this retrospective study completed in the canton of Vaud, Switzerland were to determine both the incidence of SCD and the autopsy rate for individuals from 5 to 39 years of age.
The study was conducted from 2000 to 2007 on the basis of official statistics and analysis of the International Classification of Diseases codes for potential SCDs and other deaths that might have been due to cardiac disease.
During the 8 year study period there was an average of 292′546 persons aged 5-39 and there were a total of 1122 deaths, certified as potential SCDs in 3.6% of cases. The calculated incidence is 1.71/100′000 person-years (2.73 for men and 0.69 for women). If all possible cases of SCD (unexplained deaths, drowning, traffic accidents, etc.) are included, the incidence increases to 13.67/100′000 person-years. However, the quality of the officially available data was insufficient to provide an accurate incidence of SCD as well as autopsy rates. The presumed autopsy rate of sudden deaths classified as diseases of the circulatory system is 47.5%. For deaths of unknown cause (11.1% of the deaths), the autopsy was conducted in 13.7% of the cases according to codified data.
The incidence of presumed SCD in the canton of Vaud, Switzerland, is comparable to the data published in the literature for other geographic regions but may be underestimated as it does not take into account other potential SCDs, as unexplained deaths. Increasing the autopsy rate of SCD in the young, better management of information obtained from autopsies as well developing of structured registry could improve the reliability of the statistical data, optimize the diagnostic procedures, and the preventive measures for the family members.
WHO: Cardiovascular diseases: fact sheet. http://www.who.int/mediacentre/factsheets/fs317/fr/index.html,
Swiss Statistics: Heath, key figures. http://www.bfs.admin.ch/bfs/portal/fr/index/themen/14/01/key.html,
Swiss Statistics: Mortality, causes of death - data, indicators. http://www.bfs.admin.ch/bfs/portal/fr/index/themen/14/02/04/key/01.html,
Michaud K, Fellmann F, Abriel H, Beckmann JS, Mangin P, Elger BS: Molecular autopsy in sudden cardiac death and its implication for families: discussion of the practical, legal and ethical aspects of the multidisciplinary collaboration. Swiss Med Wkly. 2009, 139 (49–50): 712-718. PubMed
Campuzano O, Allegue C, Partemi S, Iglesias A, Oliva A, Brugada R: Negative autopsy and sudden cardiac death. Int J Legal Med. 2014, 128: 4-599. 606 CrossRef
Van der Werf C, Hofman N, Tan HL, Van Dessel PF, Alders M, Van der Wal AC, Van Langen IM, Wilde AAM: Diagnostic yield in sudden unexplained death and aborted cardiac arrest in the young: the experience of a tertiary referral center in The Netherlands. Heart Rhythm. 2010, 7 (10): 1383-1389. 10.1016/j.hrthm.2010.05.036. CrossRefPubMed
Behr ER, Dalageorgou C, Christiansen M, Syrris P, Hughes S, Tome Esteban MT, Rowland E, Jeffery S, McKenna WJ: Sudden arrhythmic death syndrome: familial evaluation identifies inheritable heart disease in the majority of families. Eur Heart J. 2008, 29 (13): 1670-1680. 10.1093/eurheartj/ehn219. CrossRefPubMed
Pilmer CM, Porter B, Kirsh JA, Hicks AL, Gledhill N, Jamnik V, Faught BE, Hildebrandt D, McCartney N, Gow RM, Goodman J, Krahn AD: Scope and nature of sudden cardiac death before age 40 in Ontario: a report from the Cardiac Death Advisory Committee of the Office of the Chief Coroner. Heart Rhythm. 2013, 10 (4): 517-523. 10.1016/j.hrthm.2012.12.003. CrossRefPubMed
Statistique des causes de décès en Suisse: Directives concernant l’attestation médicale des causes de décès. http://www.iumsp.ch/Publications/pub/DirCauseDeces_1991.pdf,
Eckart RE, Scoville SL, Campbell CL, Shry EA, Stajduhar KC, Potter RN, Pearse LA, Virmani R: Sudden death in young adults: a 25-year review of autopsies in military recruits.[see comment] [summary for patients in Ann Intern Med. 2004 Dec 7;141(11):I26; PMID: 15583219]. Ann Intern Med. 2004, 141 (11): 829-834. 10.7326/0003-4819-141-11-200412070-00005. CrossRefPubMed
Oliva A, Flores J, Merigioli S, LeDuc L, Benito B, Partemi S, Arzamendi D, Campuzano O, Leung TL, Iglesias A, Talajic M, Pascali VL, Brugada R: Autopsy investigation and Bayesian approach to coronary artery disease in victims of motor-vehicle accidents. Atherosclerosis. 2011, 218 (1): 28-32. 10.1016/j.atherosclerosis.2011.05.012. CrossRefPubMed
- Sudden cardiac death in the young (5-39 years) in the canton of Vaud, Switzerland
- BioMed Central
Neu im Fachgebiet Kardiologie
Mail Icon II