Skip to main content
Erschienen in: Forensic Science, Medicine and Pathology 1/2011

01.03.2011 | Case Report

Sudden death due to adrenal neuroblastoma: child abuse mimic?

verfasst von: Ko Un Park, Joseph A. Prahlow

Erschienen in: Forensic Science, Medicine and Pathology | Ausgabe 1/2011

Einloggen, um Zugang zu erhalten

Abstract

Neuroblastoma is one of the most common malignancies in children. It is a tumor that can clinically present with varied symptoms that can mimic other entities, including child abuse. It is important that forensic pathologists are aware of the diseases that can masquerade as child abuse. A case of sudden, unexpected death in a 2-year-old due to previously undiagnosed neuroblastoma is presented. At initial presentation of the child in the emergency department, child abuse was considered as a possible explanation for the sudden demise. Death occurred before a full clinical workup could be completed and an autopsy was performed which unveiled the cause of death.
Literatur
1.
Zurück zum Zitat Spottswood SE, Narla LD. Spectrum of adrenal lesions in children. Acad Radiol. 1999;6:433–43.CrossRefPubMed Spottswood SE, Narla LD. Spectrum of adrenal lesions in children. Acad Radiol. 1999;6:433–43.CrossRefPubMed
2.
Zurück zum Zitat Golden CB, Feusner JH. Malignant abdominal masses in children: quick guide to evaluation and diagnosis. Pediatr Clin North Am. 2002;49:1369–92.CrossRefPubMed Golden CB, Feusner JH. Malignant abdominal masses in children: quick guide to evaluation and diagnosis. Pediatr Clin North Am. 2002;49:1369–92.CrossRefPubMed
3.
Zurück zum Zitat Park JR, Eggert A, Caron H. Neuroblastoma: biology, prognosis, and treatment. Hematol Oncol Clin North Am. 2010;24:65–86.CrossRefPubMed Park JR, Eggert A, Caron H. Neuroblastoma: biology, prognosis, and treatment. Hematol Oncol Clin North Am. 2010;24:65–86.CrossRefPubMed
4.
Zurück zum Zitat Meersman A, et al. Acute retroperitoneal hemorrhage and shock as presenting signs of neuroblastoma in an infant. Pediatr Emerg Care. 2008;24:37–8.CrossRefPubMed Meersman A, et al. Acute retroperitoneal hemorrhage and shock as presenting signs of neuroblastoma in an infant. Pediatr Emerg Care. 2008;24:37–8.CrossRefPubMed
5.
Zurück zum Zitat Brock CE, Ricketts RR. Hemoperitoneum from spontaneous rupture of neonatal neuroblastoma. Am J Dis Child. 1982;136:370–1.PubMed Brock CE, Ricketts RR. Hemoperitoneum from spontaneous rupture of neonatal neuroblastoma. Am J Dis Child. 1982;136:370–1.PubMed
6.
Zurück zum Zitat Gertner M, Rodriguez L, Barnett SH, Shah K. Group A beta-hemolytic streptococcus and Waterhouse-Friderichsen syndrome. Pediatr Infect Dis J. 1992;11:595–6.CrossRefPubMed Gertner M, Rodriguez L, Barnett SH, Shah K. Group A beta-hemolytic streptococcus and Waterhouse-Friderichsen syndrome. Pediatr Infect Dis J. 1992;11:595–6.CrossRefPubMed
7.
Zurück zum Zitat Laposata ME, Laposata M. Children with signs of abuse: when is it not child abuse? Am J Clin Pathol. 2005;123(Suppl):S119–24.PubMed Laposata ME, Laposata M. Children with signs of abuse: when is it not child abuse? Am J Clin Pathol. 2005;123(Suppl):S119–24.PubMed
8.
Zurück zum Zitat Kos L, Shwayder T. Cutaneous manifestations of child abuse. Pediatr Dermatol. 2006;23:311–20.CrossRefPubMed Kos L, Shwayder T. Cutaneous manifestations of child abuse. Pediatr Dermatol. 2006;23:311–20.CrossRefPubMed
9.
10.
Zurück zum Zitat Hawthorne HC Jr, Nelson JS, Witzleben CL, Giangiacomo J. Blanching subcutaneous nodules in neonatal neuroblastoma. J Pediatr. 1970;77:297–300.CrossRefPubMed Hawthorne HC Jr, Nelson JS, Witzleben CL, Giangiacomo J. Blanching subcutaneous nodules in neonatal neuroblastoma. J Pediatr. 1970;77:297–300.CrossRefPubMed
11.
Zurück zum Zitat Quinn JJ, Altman AJ. The multiple hematologic manifestations of neuroblastoma. Am J Pediatr Hematol Oncol. 1979;1:201–5.CrossRefPubMed Quinn JJ, Altman AJ. The multiple hematologic manifestations of neuroblastoma. Am J Pediatr Hematol Oncol. 1979;1:201–5.CrossRefPubMed
12.
13.
Zurück zum Zitat Hamre MR, Williams J, Chuba P, Bhambhani K, Ravindranath Y, Severson RK. Early deaths in childhood cancer. Med Pediatr Oncol. 2000;34:343–7.CrossRefPubMed Hamre MR, Williams J, Chuba P, Bhambhani K, Ravindranath Y, Severson RK. Early deaths in childhood cancer. Med Pediatr Oncol. 2000;34:343–7.CrossRefPubMed
14.
Zurück zum Zitat Krous HF, Chadwick AE, Isaacs H. Tumors associated with sudden infant and childhood death. Ped Develop Pathol. 2005;8:20–5.CrossRef Krous HF, Chadwick AE, Isaacs H. Tumors associated with sudden infant and childhood death. Ped Develop Pathol. 2005;8:20–5.CrossRef
15.
Zurück zum Zitat Inagaki J, Rodriguez V, Bodey GP. Causes of death in cancer patients. Cancer. 1974;33:568–73.CrossRefPubMed Inagaki J, Rodriguez V, Bodey GP. Causes of death in cancer patients. Cancer. 1974;33:568–73.CrossRefPubMed
16.
Zurück zum Zitat Nimkin K. Adrenal hemorrhage in abused children: imaging and postmortem findings. AJR Am J Roentgenol. 1994;162:661–3.PubMed Nimkin K. Adrenal hemorrhage in abused children: imaging and postmortem findings. AJR Am J Roentgenol. 1994;162:661–3.PubMed
17.
Zurück zum Zitat Dye DW, Peretti FJ, Kokes CP. Histologic evidence of repetitive blunt force abdominal trauma in four pediatric fatalities. J Forensic Sci. 2008;53:1430–3.PubMed Dye DW, Peretti FJ, Kokes CP. Histologic evidence of repetitive blunt force abdominal trauma in four pediatric fatalities. J Forensic Sci. 2008;53:1430–3.PubMed
Metadaten
Titel
Sudden death due to adrenal neuroblastoma: child abuse mimic?
verfasst von
Ko Un Park
Joseph A. Prahlow
Publikationsdatum
01.03.2011
Verlag
Springer US
Erschienen in
Forensic Science, Medicine and Pathology / Ausgabe 1/2011
Print ISSN: 1547-769X
Elektronische ISSN: 1556-2891
DOI
https://doi.org/10.1007/s12024-010-9193-6

Weitere Artikel der Ausgabe 1/2011

Forensic Science, Medicine and Pathology 1/2011 Zur Ausgabe

Neu im Fachgebiet Pathologie