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Literatur
1.
Zurück zum Zitat Sparks RB, Aydogan B. Comparison of the effectiveness of some common animal data scaling techniques in estimating human radiation dose. Sixth International Radiopharmaceutical Dosimetry Symposium. Stelson AS, editor. Oak Ridge:Associated Universities; 1999. p. 705–716. Sparks RB, Aydogan B. Comparison of the effectiveness of some common animal data scaling techniques in estimating human radiation dose. Sixth International Radiopharmaceutical Dosimetry Symposium. Stelson AS, editor. Oak Ridge:Associated Universities; 1999. p. 705–716.
2.
Zurück zum Zitat Sprague DR, Fujita M, Ryu YH, Liow JS, Pike VW, Innis RB. Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analyses. Nucl Med Biol 2008;35:493–500.PubMedCrossRef Sprague DR, Fujita M, Ryu YH, Liow JS, Pike VW, Innis RB. Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analyses. Nucl Med Biol 2008;35:493–500.PubMedCrossRef
3.
Zurück zum Zitat Brown AK, Fujita M, Fujimura Y, Liow J-S, Stabin M, Ryu YH, et al. Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28, a PET radioligand to image inflammation. J Nucl Med 2007;48:2072–9.PubMedCrossRef Brown AK, Fujita M, Fujimura Y, Liow J-S, Stabin M, Ryu YH, et al. Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28, a PET radioligand to image inflammation. J Nucl Med 2007;48:2072–9.PubMedCrossRef
4.
Zurück zum Zitat NIH RSC report: improving informed consent for research radiation studies, 10/17/2001. NIH RSC report: improving informed consent for research radiation studies, 10/17/2001.
5.
Zurück zum Zitat Gatley SJ. Estimation of upper limits on human radiation absorbed doses from carbon-11-labeled compounds. J Nucl Med 1993;34:2208–15.PubMed Gatley SJ. Estimation of upper limits on human radiation absorbed doses from carbon-11-labeled compounds. J Nucl Med 1993;34:2208–15.PubMed
6.
Zurück zum Zitat Parsey RV, Belanger MJ, Sullivan GM, Simpson NR, Stabin MG, Van Heertum R, et al. Biodistribution and radiation dosimetry of 11C-WAY100,635 in humans. J Nucl Med 2005;46:614–9.PubMed Parsey RV, Belanger MJ, Sullivan GM, Simpson NR, Stabin MG, Van Heertum R, et al. Biodistribution and radiation dosimetry of 11C-WAY100,635 in humans. J Nucl Med 2005;46:614–9.PubMed
7.
Zurück zum Zitat Parsey RV, Sokol LO, Bélanger MJ, Kumar JS, Simpson NR, Wang T, et al. Amyloid plaque imaging agent [C-11]-6-OH-BTA-1: biodistribution and radiation dosimetry in baboon. Nucl Med Commun 2005;26:875–80.PubMedCrossRef Parsey RV, Sokol LO, Bélanger MJ, Kumar JS, Simpson NR, Wang T, et al. Amyloid plaque imaging agent [C-11]-6-OH-BTA-1: biodistribution and radiation dosimetry in baboon. Nucl Med Commun 2005;26:875–80.PubMedCrossRef
8.
Zurück zum Zitat Thees S, Neumaier B, Glatting G, Deisenhofer S, von Arnim CA, Reske SN, et al. Radiation dosimetry and biodistribution of the beta-amyloid plaque imaging tracer 11C-BTA-1 in humans. Nuklearmedizin 2007;46:175–80.PubMed Thees S, Neumaier B, Glatting G, Deisenhofer S, von Arnim CA, Reske SN, et al. Radiation dosimetry and biodistribution of the beta-amyloid plaque imaging tracer 11C-BTA-1 in humans. Nuklearmedizin 2007;46:175–80.PubMed
9.
Zurück zum Zitat Tipre DN, Fujita M, Chin FT, Seneca N, Vines D, Liow JS, et al. Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine transporter probe 18F-FECNT in non-human primates. Nucl Med Commun 2004;25:737–42.PubMedCrossRef Tipre DN, Fujita M, Chin FT, Seneca N, Vines D, Liow JS, et al. Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine transporter probe 18F-FECNT in non-human primates. Nucl Med Commun 2004;25:737–42.PubMedCrossRef
10.
Zurück zum Zitat Lu JQ, Ichise M, Liow JS, Ghose S, Vines D, Innis RB. Biodistribution and radiation dosimetry of the serotonin transporter ligand 11C-DASB determined from human whole-body PET. J Nucl Med 2004;45:1555–9.PubMed Lu JQ, Ichise M, Liow JS, Ghose S, Vines D, Innis RB. Biodistribution and radiation dosimetry of the serotonin transporter ligand 11C-DASB determined from human whole-body PET. J Nucl Med 2004;45:1555–9.PubMed
11.
Zurück zum Zitat Hines CS, Liow JS, Zanotti-Fregonara P, Hirvonen J, Morse C, Pike VW, et al. Human biodistribution and dosimetry of 11C-CUMI-101, an agonist radioligand for serotonin-1a receptors in brain. PLoS One 2011;6:e25309.PubMedCrossRef Hines CS, Liow JS, Zanotti-Fregonara P, Hirvonen J, Morse C, Pike VW, et al. Human biodistribution and dosimetry of 11C-CUMI-101, an agonist radioligand for serotonin-1a receptors in brain. PLoS One 2011;6:e25309.PubMedCrossRef
13.
Zurück zum Zitat Terry GE, Hirvonen J, Liow JS, Seneca N, Tauscher JT, Schaus JM, et al. Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography. Eur J Nucl Med Mol Imaging 2010;37:1499–506.PubMedCrossRef Terry GE, Hirvonen J, Liow JS, Seneca N, Tauscher JT, Schaus JM, et al. Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography. Eur J Nucl Med Mol Imaging 2010;37:1499–506.PubMedCrossRef
14.
Zurück zum Zitat Liow JS, Kreisl W, Zoghbi SS, Lazarova N, Seneca N, Gladding RL, et al. P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys. J Nucl Med 2009;50:108–15.PubMedCrossRef Liow JS, Kreisl W, Zoghbi SS, Lazarova N, Seneca N, Gladding RL, et al. P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys. J Nucl Med 2009;50:108–15.PubMedCrossRef
15.
Zurück zum Zitat Seneca N, Zoghbi SS, Liow JS, Kreisl W, Herscovitch P, Jenko K, et al. Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein. J Nucl Med 2009;50:807–13.PubMedCrossRef Seneca N, Zoghbi SS, Liow JS, Kreisl W, Herscovitch P, Jenko K, et al. Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein. J Nucl Med 2009;50:807–13.PubMedCrossRef
16.
Zurück zum Zitat Hirvonen J, Roivainen A, Virta J, Helin S, Någren K, Rinne JO. Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation. Eur J Nucl Med Mol Imaging 2010;37:606–12.PubMedCrossRef Hirvonen J, Roivainen A, Virta J, Helin S, Någren K, Rinne JO. Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation. Eur J Nucl Med Mol Imaging 2010;37:606–12.PubMedCrossRef
17.
Zurück zum Zitat Kumar A, Muzik O, Chugani D, Chakraborty P, Chugani HT. PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults. J Nucl Med 2010;51:139–44.PubMedCrossRef Kumar A, Muzik O, Chugani D, Chakraborty P, Chugani HT. PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults. J Nucl Med 2010;51:139–44.PubMedCrossRef
18.
Zurück zum Zitat Herscovitch P, Schmall B, Doudet D, Carson R, Eckelman WC. Biodistribution and radiation dose estimates for [C-11]raclopride. J Nucl Med 1997;38:224P. Herscovitch P, Schmall B, Doudet D, Carson R, Eckelman WC. Biodistribution and radiation dose estimates for [C-11]raclopride. J Nucl Med 1997;38:224P.
19.
Zurück zum Zitat Slifstein M, Hwang DR, Martinez D, Ekelund J, Huang Y, Hackett E, et al. Biodistribution and radiation dosimetry of the dopamine D2 ligand 11C-raclopride determined from human whole-body PET. J Nucl Med 2006;47:313–9.PubMed Slifstein M, Hwang DR, Martinez D, Ekelund J, Huang Y, Hackett E, et al. Biodistribution and radiation dosimetry of the dopamine D2 ligand 11C-raclopride determined from human whole-body PET. J Nucl Med 2006;47:313–9.PubMed
20.
Zurück zum Zitat Ribeiro MJ, Ricard M, Bourgeois S, Lièvre MA, Bottlaender M, Gervais P, et al. Biodistribution and radiation dosimetry of [11C]raclopride in healthy volunteers. Eur J Nucl Med Mol Imaging 2005;32:952–8.PubMedCrossRef Ribeiro MJ, Ricard M, Bourgeois S, Lièvre MA, Bottlaender M, Gervais P, et al. Biodistribution and radiation dosimetry of [11C]raclopride in healthy volunteers. Eur J Nucl Med Mol Imaging 2005;32:952–8.PubMedCrossRef
21.
Zurück zum Zitat Graham MM, Peterson LM, Muzi M, Graham BB, Spence AM, Link JM, et al. 1-[Carbon-11]-glucose radiation dosimetry and distribution in human imaging studies. J Nucl Med 1998;39:1805–10.PubMed Graham MM, Peterson LM, Muzi M, Graham BB, Spence AM, Link JM, et al. 1-[Carbon-11]-glucose radiation dosimetry and distribution in human imaging studies. J Nucl Med 1998;39:1805–10.PubMed
22.
Zurück zum Zitat Laymon CM, Mason NS, Frankle WG, Carney JP, Lopresti BJ, Litschge MY, et al. Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET. J Nucl Med 2009;50:814–7.PubMedCrossRef Laymon CM, Mason NS, Frankle WG, Carney JP, Lopresti BJ, Litschge MY, et al. Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET. J Nucl Med 2009;50:814–7.PubMedCrossRef
23.
Zurück zum Zitat Treyer V, Streffer J, Ametamey SM, Bettio A, Bläuenstein P, Schmidt M, et al. Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteers. Eur J Nucl Med Mol Imaging 2008;35:766–70.PubMedCrossRef Treyer V, Streffer J, Ametamey SM, Bettio A, Bläuenstein P, Schmidt M, et al. Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteers. Eur J Nucl Med Mol Imaging 2008;35:766–70.PubMedCrossRef
24.
Zurück zum Zitat Thierens H, van Eijkeren M, Goethals P. Biokinetics and dosimetry for [methyl-11C]thymidine. Br J Radiol 1994;67:292–5.PubMedCrossRef Thierens H, van Eijkeren M, Goethals P. Biokinetics and dosimetry for [methyl-11C]thymidine. Br J Radiol 1994;67:292–5.PubMedCrossRef
25.
Zurück zum Zitat Bullich S, Slifstein M, Passchier J, Murthy NV, Kegeles LS, Kim JH, et al. Biodistribution and radiation dosimetry of the glycine transporter-1 ligand (11)C-GSK931145 determined from primate and human whole-body PET. Mol Imaging Biol 2011;13:776–84.PubMedCrossRef Bullich S, Slifstein M, Passchier J, Murthy NV, Kegeles LS, Kim JH, et al. Biodistribution and radiation dosimetry of the glycine transporter-1 ligand (11)C-GSK931145 determined from primate and human whole-body PET. Mol Imaging Biol 2011;13:776–84.PubMedCrossRef
26.
Zurück zum Zitat Tolvanen T, Någren K, Yu M, Sutinen E, Havu-Aurén K, Jyrkkiö S, et al. Human radiation dosimetry of [11C]MeAIB, a new tracer for imaging of system A amino acid transport. Eur J Nucl Med Mol Imaging 2006;33:1178–84.PubMedCrossRef Tolvanen T, Någren K, Yu M, Sutinen E, Havu-Aurén K, Jyrkkiö S, et al. Human radiation dosimetry of [11C]MeAIB, a new tracer for imaging of system A amino acid transport. Eur J Nucl Med Mol Imaging 2006;33:1178–84.PubMedCrossRef
27.
Zurück zum Zitat Liu N, Li M, Li X, Meng X, Yang G, Zhao S, et al. PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans. J Nucl Med 2009;50:303–8.PubMedCrossRef Liu N, Li M, Li X, Meng X, Yang G, Zhao S, et al. PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans. J Nucl Med 2009;50:303–8.PubMedCrossRef
28.
Zurück zum Zitat Virta JR, Tolvanen T, Någren K, Bruck A, Roivainen A, Rinne JO. 1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation. J Nucl Med 2008;49:347–53.PubMedCrossRef Virta JR, Tolvanen T, Någren K, Bruck A, Roivainen A, Rinne JO. 1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation. J Nucl Med 2008;49:347–53.PubMedCrossRef
29.
Zurück zum Zitat Tolvanen T, Yli-Kerttula T, Ujula T, Autio A, Lehikoinen P, Minn H, et al. Biodistribution and radiation dosimetry of [(11)C]choline: a comparison between rat and human data. Eur J Nucl Med Mol Imaging 2010;37:874–83.PubMedCrossRef Tolvanen T, Yli-Kerttula T, Ujula T, Autio A, Lehikoinen P, Minn H, et al. Biodistribution and radiation dosimetry of [(11)C]choline: a comparison between rat and human data. Eur J Nucl Med Mol Imaging 2010;37:874–83.PubMedCrossRef
30.
Zurück zum Zitat Newberg AB, Ray R, Scheuermann J, Wintering N, Saffer J, Schmitz A, et al. Dosimetry of 11C-carfentanil, a micro-opioid receptor imaging agent. Nucl Med Commun 2009;30:314–8.PubMedCrossRef Newberg AB, Ray R, Scheuermann J, Wintering N, Saffer J, Schmitz A, et al. Dosimetry of 11C-carfentanil, a micro-opioid receptor imaging agent. Nucl Med Commun 2009;30:314–8.PubMedCrossRef
31.
Zurück zum Zitat van der Veldt AA, Hendrikse NH, Smit EF, Mooijer MP, Rijnders AY, Gerritsen WR, et al. Biodistribution and radiation dosimetry of 11C-labelled docetaxel in cancer patients. Eur J Nucl Med Mol Imaging 2010;37:1950–8.PubMedCrossRef van der Veldt AA, Hendrikse NH, Smit EF, Mooijer MP, Rijnders AY, Gerritsen WR, et al. Biodistribution and radiation dosimetry of 11C-labelled docetaxel in cancer patients. Eur J Nucl Med Mol Imaging 2010;37:1950–8.PubMedCrossRef
32.
Zurück zum Zitat Scheinin NM, Tolvanen TK, Wilson IA, Arponen EM, Någren KA, Rinne JO. Biodistribution and radiation dosimetry of the amyloid imaging agent 11C-PIB in humans. J Nucl Med 2007;48:128–33.PubMed Scheinin NM, Tolvanen TK, Wilson IA, Arponen EM, Någren KA, Rinne JO. Biodistribution and radiation dosimetry of the amyloid imaging agent 11C-PIB in humans. J Nucl Med 2007;48:128–33.PubMed
33.
Zurück zum Zitat Santens P, De Vos F, Thierens H, Decoo D, Slegers G, Dierckx RA, et al. Biodistribution and dosimetry of carbon-11-methoxyprogabidic acid, a possible ligand for GABA-receptors in the brain. J Nucl Med 1998;39:307–10.PubMed Santens P, De Vos F, Thierens H, Decoo D, Slegers G, Dierckx RA, et al. Biodistribution and dosimetry of carbon-11-methoxyprogabidic acid, a possible ligand for GABA-receptors in the brain. J Nucl Med 1998;39:307–10.PubMed
34.
Zurück zum Zitat Seltzer MA, Jahan SA, Sparks R, Stout DB, Satyamurthy N, Dahlborn M, et al. Radiation dose estimates in humans for (11)C-acetate whole-body PET. J Nucl Med 2004;45:1233–6.PubMed Seltzer MA, Jahan SA, Sparks R, Stout DB, Satyamurthy N, Dahlborn M, et al. Radiation dose estimates in humans for (11)C-acetate whole-body PET. J Nucl Med 2004;45:1233–6.PubMed
35.
Zurück zum Zitat Nugent AC, Neumeister A, Drevets WC, Eckelman WC, Channing MA, Herscovitch P. Human biodistribution and dosimetry of the PET benzodiazepine receptor ligand [11C]flumazenil. J Nucl Med 2004;45(Suppl):434P. Nugent AC, Neumeister A, Drevets WC, Eckelman WC, Channing MA, Herscovitch P. Human biodistribution and dosimetry of the PET benzodiazepine receptor ligand [11C]flumazenil. J Nucl Med 2004;45(Suppl):434P.
36.
Zurück zum Zitat Deloar HM, Fujiwara T, Nakamura T, Itoh M, Imai D, Miyake M, et al. Estimation of internal absorbed dose of L-[methyl-11C]methionine using whole-body positron emission tomography. Eur J Nucl Med 1998;25:629–33.PubMedCrossRef Deloar HM, Fujiwara T, Nakamura T, Itoh M, Imai D, Miyake M, et al. Estimation of internal absorbed dose of L-[methyl-11C]methionine using whole-body positron emission tomography. Eur J Nucl Med 1998;25:629–33.PubMedCrossRef
37.
Zurück zum Zitat O’Keefe GJ, Saunder TH, Ng S, Ackerman U, Tochon-Danguy HJ, Chan JG, et al. Radiation dosimetry of beta-amyloid tracers 11C-PiB and 18F-BAY94-9172. J Nucl Med 2009;50:309–15.PubMedCrossRef O’Keefe GJ, Saunder TH, Ng S, Ackerman U, Tochon-Danguy HJ, Chan JG, et al. Radiation dosimetry of beta-amyloid tracers 11C-PiB and 18F-BAY94-9172. J Nucl Med 2009;50:309–15.PubMedCrossRef
38.
Zurück zum Zitat Cropley VL, Fujita M, Musachio JL, Hong J, Ghose S, Sangare J, et al. Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand, (11)C-NNC 112, in humans. J Nucl Med 2006;47:100–4.PubMed Cropley VL, Fujita M, Musachio JL, Hong J, Ghose S, Sangare J, et al. Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand, (11)C-NNC 112, in humans. J Nucl Med 2006;47:100–4.PubMed
39.
Zurück zum Zitat Ribeiro MJ, Ricard M, Lièvre MA, Bourgeois S, Emond P, Gervais P, et al. Whole-body distribution and radiation dosimetry of the dopamine transporter radioligand [(11)C]PE2I in healthy volunteers. Nucl Med Biol 2007;34:465–70.PubMedCrossRef Ribeiro MJ, Ricard M, Lièvre MA, Bourgeois S, Emond P, Gervais P, et al. Whole-body distribution and radiation dosimetry of the dopamine transporter radioligand [(11)C]PE2I in healthy volunteers. Nucl Med Biol 2007;34:465–70.PubMedCrossRef
40.
Zurück zum Zitat Marthi K, Hansen SB, Jakobsen S, Bender D, Smith SB, Smith DF. Biodistribution and radiation dosimetry of [N-methyl-11C]mirtazapine, an antidepressant affecting adrenoceptors. Appl Radiat Isot 2003;59:175–9.PubMedCrossRef Marthi K, Hansen SB, Jakobsen S, Bender D, Smith SB, Smith DF. Biodistribution and radiation dosimetry of [N-methyl-11C]mirtazapine, an antidepressant affecting adrenoceptors. Appl Radiat Isot 2003;59:175–9.PubMedCrossRef
Metadaten
Titel
Suggested pathway to assess radiation safety of 11C-labeled PET tracers for first-in-human studies
verfasst von
Paolo Zanotti-Fregonara
Robert B. Innis
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 3/2012
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-011-2005-8

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