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Erschienen in: Tumor Biology 12/2014

01.12.2014 | Research Article

SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9

verfasst von: Chenchao Ma, Bo Wu, Xinyu Huang, Zhou Yuan, Kate Nong, Bo Dong, Yueqing Bai, Hongda Zhu, Weiwei Wang, Kaixing Ai

Erschienen in: Tumor Biology | Ausgabe 12/2014

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Abstract

SUMOylation is a dynamic process which can be reversed by a family of sentrin/SUMO-specific protease (SENPs). Recently, SENP1, a member of SENPs family was shown to have a pro-oncogenic role in many types of cancer. Here, we showed that SENP1 was upregulated in pancreatic ductal adenocarcinoma (PDAC) tissues compared with adjacent normal tissues. Moreover, clinical data showed that SENP1 was positively associated with lymph node metastasis and TNM stage. Furthermore, knockdown of SENP1 by SENP1-siRNA inhibited pancreatic cancer cell proliferation, migration, and invasion, suggesting that SENP1 played an important role in PDAC progression and metastasis. Mechanistically, silencing of SENP1 results in downregulation of MMP-9, which is pivotal for PDAC cell growth and migration. Taken together, these results suggest that SENP1 may serve as a potential novel diagnostic and therapeutic target of PDAC.
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Metadaten
Titel
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9
verfasst von
Chenchao Ma
Bo Wu
Xinyu Huang
Zhou Yuan
Kate Nong
Bo Dong
Yueqing Bai
Hongda Zhu
Weiwei Wang
Kaixing Ai
Publikationsdatum
01.12.2014
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 12/2014
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-014-2598-1

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