The online version of this article (doi:10.1186/1752-1947-6-361) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
SL was the physician for the patient in the manuscript and was a contributor in writing the manuscript. OH was a major contributor in writing the molecular neurobiology segments of the manuscript, as well as the main editor. DM was the chief editor of this manuscript. JA and TM have also contributed to the various editorial comments and to preparing the manuscript, and histological examination. JS contributed to the surgical segment of the manuscript and was the main attending neurosurgeon for this case. RG contributed the neuro-radiology included with the manuscript. All authors read and approved the final manuscript.
Supratentorial primitive neuroectodermal tumors predominantly occur in children, and are rare in the adult population. Less than 100 cases of supratentorial primitive neuroectodermal tumor have been reported in adults internationally. Our case study reports this rare incident.
A 22-year-old Hispanic man presented with headaches, blurry vision, diplopia, intermittent vomiting, and grossly decreased vision. A magnetic resonance image showed a left posterior parietal heterogeneously enhancing mass measuring 4.2cm × 7.2cm × 7.0cm. After craniotomy for resection and decompression, the mass was histologically revealed to be a supratentorial primitive neuroectodermal tumor. Standardized immunohistochemical studies for this mass were carried out.
We have concluded that immunohistochemical and genetic workup should be included in the standardized pathological workup for primitive neuroectodermal tumors in order to provide more prognostic information. Based on our current literature review, we propose an immunohistochemical panel.
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- Supratentorial primitive neuroectodermal tumor in an adult: a case report and review of the literature
Omid R Hariri
Dan E Miulli
Ravi K Gupta
- BioMed Central