Erschienen in:
12.03.2019 | Endocrine Tumors
Surgery for Pancreatic Neuroendocrine Tumor G3 and Carcinoma G3 Should be Considered Separately
verfasst von:
Tsukasa Yoshida, MD, Susumu Hijioka, MD, PhD, Waki Hosoda, MD, PhD, Makoto Ueno, MD, Masayuki Furukawa, MD, PhD, Noritoshi Kobayashi, MD, PhD, Masafumi Ikeda, MD, Tetsuhide Ito, MD, PhD, Yuzo Kodama, MD, PhD, Chigusa Morizane, MD, PhD, Kenji Notohara, MD, PhD, Hiroki Taguchi, MD, PhD, Masayuki Kitano, MD, PhD, Kei Yane, MD, Yoshiaki Tsuchiya, MD, Izumi Komoto, MD, PhD, Hiroki Tanaka, MD, Akihito Tsuji, MD, PhD, Syunpei Hashigo, MD, Tetsuya Mine, MD, PhD, Atsushi Kanno, MD, PhD, Go Murohisa, MD, PhD, Katsuyuki Miyabe, MD, PhD, Tadayuki Takagi, MD, PhD, Nobutaka Matayoshi, MD, Masafumi Sakaguchi, MD, Hiroshi Ishii, MD, Yasushi Kojima, MD, PhD, Keitaro Matsuo, MD, PhD, Hideyuki Yoshitomi, MD, PhD, Shoji Nakamori, MD, PhD, Hiroaki Yanagimoto, MD, PhD, Yasushi Yatabe, MD, PhD, Junji Furuse, MD, PhD, Nobumasa Mizuno, MD, PhD
Erschienen in:
Annals of Surgical Oncology
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Ausgabe 5/2019
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Abstract
Background
The role of surgery in pancreatic neuroendocrine neoplasm grade 3 (pNEN-G3) treatment remains unclear. We aimed to clarify the role of surgery for pNEN-G3, which has recently been reclassified as pancreatic neuroendocrine tumor-G3 (pNET-G3) and pancreatic neuroendocrine carcinoma-G3 (pNEC-G3), with and without metastases, respectively.
Methods
We analyzed a subgroup of patients from the Japanese pancreatic NEC study, a Japanese multicenter case-series study of pNEN-G3. Pathologists subclassified 67 patients as having pNET-G3 or pNEC-G3 based on morphological features. We compared the overall survival (OS) rates among patients who were grouped according to whether they had undergone tumor-targeted surgery for tumors without (SwoM) or with (SwM) metastases, or non-surgical procedures (NS).
Results
Data from 21 patients with pNET-G3 (SwoM, n = 6; SwM, n = 5; NS, n = 10) and 46 patients with pNEC-G3 (SwoM, n = 8; SwM, n = 5; NS, n = 33) were analyzed. OS of patients with pNET-G3 was significantly longer after SwoM and SwM than with NS (p = 0.018 and p = 0.022). In contrast, OS did not significantly differ between either SwoM or SwM and NS (p = 0.093 and p = 0.489) among patients with pNEC-G3.
Conclusion
The role of surgery should be considered separately for pNET-G3 and pNEC-G3. Although SwoM and SwM can be considered for pNET-G3, caution is advised before considering SwM and SwoM for pNEC-G3.