Background
Methods
Data collection
Statistical analysis
Results
Chronological changes of clinical characteristics according to period
2006–2009 | 2010–2013 | 2014–2017 | p value | |
---|---|---|---|---|
Number | 7 | 11 | 7 | |
Age (years) | 39.43 ± 12.78 | 35.91 ± 15.42 | 40.71 ± 15.55 | 0.775 |
Gender (F:M) | 7:0 | 9:2 | 6:1 | 0.500 |
BMI (kg/m2) | 21.71 ± 2.87 | 22.82 ± 2.36 | 22.43 ± 2.88 | 0.694 |
Symptomatic (yes/no) | 2/5 | 5/6 | 2/5 | 0.997 |
Operation type (MI/open) | 2/5 | 5/6 | 5/2 | 0.269 |
Operation (PPPD/CP) | 3/4 | 8/3 | 5/2 | 0.389 |
Tumor size (cm) | 3.63 ± 1.91 | 4.12 ± 1.82 | 2.44 ± 0.78* | 0.126 |
Stage | 0.833 | |||
Ia | 2 (28%) | 2 | 2 (28%) | |
Ib | 5 (72%) | 9 | 5 (72%) |
General patient characteristics
Comparative analysis between MI and open surgical approaches for SPN of the proximal pancreas
Minimally invasive (n = 13) | Open (n = 12) | p value | |
---|---|---|---|
Age (years) | 41.0 ± 13.5 | 35.3 ± 15.4 | 0.326 |
Gender (F:M) | 11:2 | 11:1 | 0.588 |
Symptomatic (yes/no) | 3/10 | 6/6 | 0.161 |
BMI (kg/m2) | 22.8 ± 2.6 | 21.9 ± 2.5 | 0.380 |
Tumor size (cm) | 2.6 ± 1.0 | 4.5 ± 1.8 | 0.004* |
Preoperative stage | 0.645 | ||
Ia | 4 (30.8%) | 2 (16.7%) | |
Ib | 9 (69.2%) | 10 (83.3%) | |
Operation | 0.411 | ||
PPPD | 7 (53.8%) | 9 (75%) | |
CP | 6 (46.2%) | 3 (25%) | |
OR time (min) | 417.2 ± 115.6 | 413.9 ± 132.4 | 0.949 |
Blood loss (mL) | 277.7 ± 250.8 | 664.2 ± 512.4 | 0.024* |
Need for transfusion (yes/no) | 0/13 | 4/8 | 0.023* |
Pancreas description (soft/hard) | 13/0 | 12/0 | |
Pancreatic duct size (mm) | 1.15 ± 0.83 | 1.43 ± 1.2 | 0.496 |
Resection type | All R0 | All R0 | |
Hospital length of stay (days) | 11.5 ± 5.3 | 27.4 ± 15.3 | 0.002* |
Complication incidence | 4 (30.8%) | 9 (75%) | 0.027* |
POPF (grade A/grade B) | 2 (15.4%)/2 (15.4%) | 3 (25%)/1 (8.33%) | 0.465 |
Histopathologic outcomes
Minimally invasive (n = 13) | Open (n = 12) | p value | |
---|---|---|---|
Death associated with disease | None | None | |
Recurrence | None | None | |
Resection margin | All negative | All negative | |
Capsular invasion | 3 (23.1%) | 2 (16.7%) | 0.698 |
Lymphovascular invasion | 1 (7.69%) | 0 | 0.327 |
Perineural invasion | 3 (23.1%) | 2 (16.7%) | 0.689 |
Stage | 0.409 | ||
Ia | 4 (30.8%) | 1 (8.33%) | |
Ib | 6 (46.2%) | 9 (75%) | |
IIa | 3 (23.1%) | 2 (16.7%) |
Long-term nutritional assessment
CONUT score for severity of malnutrition | Pre-operative n (%) | 6 months post-operative n (%) | 12 months post-operative n (%) | |||
---|---|---|---|---|---|---|
Minimally invasive (n = 13) | Open (n = 12) | Minimally invasive (n = 13) | Open (n = 12) | Minimally invasive (n = 13) | Open (n = 12) | |
Normal (without deficit) | 0 | 0 | 9 (69%) | 9 (75%) | 11 (85%) | 10 (83%) |
Mild | 7 (54%) | 4 (33%) | 4 (31%) | 3 (25%) | 2 (15%) | 2 (17%) |
Moderate | 5 (38%) | 6 (50%) | 0 | 0 | 0 | 0 |
Severe | 1 (8%) | 2 (17%) | 0 | 0 | 0 | 0 |