Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma

Sarcoma is a rare cancer among adults and represents approximately 1% of all adult malignancies [1]. There are only 12,000 to 13,000 cases of adult soft tissue sarcomas (STS) per year [2]. The vast majority of STS are of the extremity or trunk, and the second largest subgroup consists of retroperitoneal sarcomas (RPS). RPS represents approximately 3000 annual cases [2] and is comprised of approximately 15 to 17% of all soft tissue sarcomas [3, 4]. The majority of retroperitoneal sarcomas are leiomyosarcomas (LMS) or liposarcomas (LPS). RPS liposarcomas consist mostly of well-differentiated and dedifferentiated liposarcomas [5, 6]. Despite improved survival rates in other cancer types, the 5-year overall survival (OS) of soft tissue sarcoma remains close to 50% [7]. For the two largest series of retroperitoneal sarcoma, the 5-year overall survival was 67% [8], the 7-year overall survival was 58%, and the 7-year disease-free survival was 38% [9].

There are several prognostic factors that can better define a patient’s survival with soft tissue sarcomas. These include size [10‐13], grade [10‐13], American Joint Committee on Cancer (AJCC) stage, location [13, 14], and histologic subtype [11‐13] of the tumor. Prognostic factors are interconnected as the histologic subtype may influence the grade of a tumor, and the staging system is based on the size, grade, and depth of the tumor [15, 16]. Location of the tumor is also quite important, as tumors in the extremity and trunk have improved survival compared to tumors in the retroperitoneum, head, and neck, or uterus [2]. The main prognostic factors for retroperitoneal sarcomas are age, grade, tumor size, histologic subtype, tumor multifocality, and extent of resection [17]. In general, retroperitoneal sarcomas have a high rate of local recurrence and low rate of distant metastasis, although this is influenced by each histologic subtype [18‐20]. For example, LPS have a high rate of local recurrence while LMS have a high rate of distant metastasis [8]. Even among retroperitoneal sarcomas of similar histology, there is variability in outcomes including recurrence and death with indolence or rapid progression with a more aggressive clinical course [21‐24].

The primary management of RPS tumors remains surgical excision. The extent of resection influences patient outcomes. Patients with negative margins or R0 resection tend to have a lower risk of local recurrence. Though given the typical size and proximity to critical abdominal structures, an R0 resection is difficult to achieve in retroperitoneal sarcomas, and the majority of patients receive an R1 resection, defined as positive microscopic margins [7, 25‐28]. Adjuvant or neoadjuvant radiation therapy has been shown to decrease the risk of local recurrence to approximately 10% in extremity soft tissue sarcomas, but the role of adjuvant or neoadjuvant radiation in retroperitoneal soft tissue sarcoma is still undetermined [29]. There is retrospective data that suggests a decrease in local recurrence with neoadjuvant or adjuvant radiation [30]. This benefit has not yet been confirmed in a prospective randomized trial. The role of adjuvant chemotherapy is debated in extremity soft tissue sarcomas and unknown in retroperitoneal soft tissue sarcomas [31, 32]. For patients that develop local recurrence and metastatic disease, survival is significantly worse 14 to 29% at 5 years [33]. Several nomograms have been developed to predict the outcome for patients with retroperitoneal soft tissue sarcomas using age, grade, tumor size, histology, radiation, the extent of resection, and tumor multifocality as prognostic factors [14, 17, 34, 35]. Although, only one of these nomograms has been externally validated [9].

We sought to evaluate the University of Maryland experience with retroperitoneal soft tissue sarcomas from 2000 to 2013 by examining the 2-year overall survival and progression-free survival based on patient, tumor, and treatment characteristics. Patient characteristics included sex, race, and age. Tumor characteristics included size, grade, depth, stage, location, and histologic subtype. Treatments examined included the extent and number of surgical resections, as well as the use of neoadjuvant or adjuvant radiation and chemotherapy. The influence of surgery on survival for patients with primary metastatic disease or recurrent disease was examined as well. The University of Maryland Medical Center in Baltimore services a local traditionally medically underserved catchment with a high African-American population. The patient population may be distinct from that of other major sarcoma centers with a national draw and is therefore of interest to consider.

With approval by the University of Maryland Institutional Review Board, a de-identified database was constructed of all patients diagnosed with sarcomas treated at UMMC between 2000 and 2013. Our inclusion criteria included 28 retroperitoneal LPS and 21 retroperitoneal LMS patients (49 total).

The diagnosis of retroperitoneal LPS or LMS was confirmed by University of Maryland pathologists. Demographic, clinicopathologic, and treatment characteristics were extracted from the patient’s medical records. Stage was assigned using the AJCC 7th edition TNM soft tissue sarcoma staging system [36]. Histologic subtypes were categorized per WHO classification. Grade was determined using the FNCLCC system [15]. Performance status was determined by the Eastern Cooperative Oncology Group performance score [37].

Patient’s demographic and clinical characteristics were descriptively examined. Categorical variables were summarized in frequency tables using Fisher’s exact test, and continuous variables were summarized using median (range) and the Wilcoxon rank sum test. Kaplan-Meier plots were used to graphically portray progression-free survival (PFS) and overall survival (OS) [38]. The log-rank test was used to compare time-to-event distributions. OS was defined as the time from the date of pathologic diagnosis to death or date last known alive. PFS was defined as the time from the date of pathologic diagnosis to the date of disease progression or death. Patients without an event were right-censored at the date of last follow-up [39].

Sarcomas are a group of rare diseases. The most common retroperitoneal sarcomas are LMS and LPS [2]. However, the natural history of these diseases differs greatly. LMS vary from slowly growing, indolent to very aggressive neoplasms [40]. By definition, these tumors are usually classified and intermediate to high grade [40]. LMS tend to have a higher rate of metastatic disease [40]. There are four different liposarcoma subtypes, the most common being well-differentiated LPS and dedifferentiated LPS, and the rarer subtypes include myxoid LPS and pleomorphic LPS, which occur less often in the retroperitoneum [41]. It is very common for retroperitoneal LPS to have both well-differentiated and dedifferentiated components [40]. Well-differentiated LPS are low-grade tumors, slowly growing, and minimally symptomatic [41]. These tumors can grow to a very large size before diagnosis, and R0 resections are uncommon. The rate of local recurrence alone for retroperitoneal LPS is greater than those with distant metastasis. Dedifferentiated LPS may be extremely aggressive [41].

These variances in retroperitoneal sarcoma natural history for both LMS and LPS are exemplified in this patient population. The LPS in this population have a higher rate of low-grade tumors, larger tumor size, and therefore higher percentage of stage I tumors. Not unexpectedly, there was a high rate of R1 and R2 resections for LPS. This is compared to the LMS population, with mostly intermediate to high-grade tumors and smaller size. Furthermore, the local recurrence rate was higher in LPS patients, and the distant recurrence rate was higher in LMS. This study showed the 2-year overall survival of 81% and 2-year progression-free survival of 45%. There was a trend towards improved survival with LPS compared to LMS, as has been previously reported [8, 9]. This trend was not statistically significant in this study but may have been influenced by the small sample size in this population.

However, one key difference of interest in the UMMC sarcoma population compared to other sarcoma centers is race, with 30% of the population black, a higher percentage of the population than reported in similar retroperitoneal sarcoma studies [8, 9]. Racial disparities in treatment and outcomes for soft tissue sarcomas have been previously noted, with black patients more likely to die of their disease [42, 43]. Our study suggests a difference in the incidence of retroperitoneal LMS and LPS by race, as most of the black patients in this population had LMS, and not LPS. This difference has not been previously noted and is worth examining in a larger patient population. Furthermore, the overall survival for black patients with leiomyosarcoma was decreased compared to Caucasian patients. This difference was not statistically significant; however, the small sample size of this population does limit statistical analysis. Larger studies of outcomes in soft tissue sarcomas have noted a correlation between race and socioeconomic status [42, 43]. In the UMMC population, socioeconomic status was difficult to quantify in a retrospective study, as family status, occupation, and income were not universally available in a retrospective record review. However, UMMC is located in Baltimore, MD, addressing the needs of a large underserved and uninsured black population. Race could be a marker for socioeconomic status. The impact of race and socioeconomic status on treatment outcomes should be examined in a larger cohort of retroperitoneal sarcoma patients.

The standard of care management of retroperitoneal sarcoma is surgical resection alone, though there is a high rate of R1 or R2 resections [23, 25, 26]. The role of chemotherapy is uncertain. Adjuvant or neoadjuvant chemotherapy is used by some high-volume sarcoma centers; however, there is no randomized controlled evidence to support the use of chemotherapy for retroperitoneal sarcomas in the curative setting [44]. Only one patient in this study received adjuvant chemotherapy. A role of adjuvant or neoadjuvant chemotherapy for retroperitoneal sarcomas cannot be recommended at this time. Adjuvant or more commonly neoadjuvant radiation is used in the treatment of retroperitoneal sarcomas to decrease the risk of local recurrence. Neoadjuvant radiation is preferred as the dose of radiation is lower, the radiation field is smaller, and abdominal structures, including bowel, can be sparred toxicity. The benefit of radiation may differ among retroperitoneal sarcoma histologies such as LMS vs. well-differentiated or dedifferentiated LPS. This study shows no benefit to adjuvant or neoadjuvant radiation, similar to previous retrospective reports [45]. However, there is a prospective randomized trial (NCT01344018) of surgery vs. neoadjuvant radiation and surgery for retroperitoneal sarcomas, which hopefully will provide more definitive data for the efficacy or lack thereof of neoadjuvant radiation for retroperitoneal sarcomas. At the moment, neoadjuvant radiation can be considered in the treatment of retroperitoneal sarcoma on a case-by-case basis. The best management for recurrent retroperitoneal sarcomas is uncertain.

Three retroperitoneal sarcoma-specific nomograms have been published. These nomograms are designed to help predict prognosis for retroperitoneal sarcoma patients. The Anaya et al. nomogram uses age, size, multifocality, primary vs. recurrence, and completeness of resection as prognostic factors [34]. The Tan et al. nomogram uses size radiation, histology, and extent of resection as prognostic factors [35]. The Gronchi et al. nomogram was externally validated and uses grade, size, age, histology, extent of resection, and multifocality as prognostic factors [9, 14]. This study provides further evidence that supports the importance of histology, extent of resection, grade, size, and therefore stage in the prognosis of retroperitoneal leiomyosarcomas and liposarcomas. Our study also suggests that race may be an underappreciated prognostic factors and although limited by its small sample size points to the need for a better understanding of racial and socioeconomic disparities in retroperitoneal sarcomas that might be possible in a larger cohort.

Previous studies have suggested a benefit of resection of recurrent disease [46]. Our study shows a trend towards improved survival for patients that underwent resection for recurrent disease, albeit not statistically significant. It is also true that more patients with LPS underwent resection for recurrent disease than LMS patients, likely influenced by the higher rate of local recurrence in LPS compared to LMS. In concordance with previous reports [46], our results suggest the strategic use of multiple successive resections when clinically feasible and emphasize that Pts able to undergo palliative surgery may attain superior survival.

Retroperitoneal sarcoma is a rare subset of cancer, most commonly including liposarcomas and leiomyosarcoma. Our study suggests a higher incidence of leiomyosarcoma in the African-American population. The standard of care treatment is surgical resection, though the role of neoadjuvant radiation is being examined. The most important prognostic factors for retroperitoneal LPS and LMS are the extent of resection, grade, and size, and race may be an important prognostic factor as well. This study was likely limited by small sample size, but our experience underscores the need for recurrent retroperitoneal sarcoma patients to be evaluated by a center experienced in undertaking extensive surgery for recurrent disease if clinically feasible.