Peripherally inserted central catheters (PICC) are widely used in patients for the administration of chemotherapy and antimicrobial drugs, parenteral nutrition, and, recently, for blood sampling, especially for cancer patients [
1‐
3]. Complications of PICCs, including accidental removal, fracture, embolization, and migration of the tip have been reported in the literature [
4,
5]. The most common complication is venous thrombosis, which can result in catheter removal, treatment interruption, and life-threatening events such as pulmonary embolism [
6]. Although catheter-related thrombi in the right atrium and the pulmonary artery are rarely reported [
7,
8], they may lead to serious complications and even death if the migrated thrombus is not removed in time [
9]. Herein, we present a case of PICC-related thrombus in the right atrium that was successfully removed surgically.