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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

Surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Monique A Dorkenoo, Amy Barrette, Yao M Agbo, Hervé Bogreau, Séenam Kutoati, Yao K Sodahlon, Kodjo Morgah
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2875-11-338) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

MD conceived and designed the study, conducted the research, collected and interpreted the data. YA conducted the research. AB performed the statistical analysis and drafted the manuscript. SK collected the data and conducted the research. HB conducted the research and performed the PCR analysis. YS conceived and designed the study, performed statistical analysis and interpretation. KM conceived and designed the study and conducted the research. All authors read and approved the final manuscript.

Abstract

Background

Malaria remains a major public health problem in Togo. The national malaria control programme in Togo changed the anti-malarial treatment policy from monotherapy to artemisinin combination therapy in 2004. This study reports the results of therapeutic efficacy studies conducted on artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Togo, between 2005 and 2009.

Methods

Children between 6 and 59 months of age, who were symptomatically infected with P. falciparum, were treated with either artemether-lumefantrine or artesunate-amodiaquine. The primary end-point was the 28-day cure rate, PCR-corrected for reinfection and recrudescence. Studies were conducted according to the standardized WHO protocol for the assessment of the efficacy of anti-malarial treatment. Differences between categorical data were compared using the chi-square test or the Fisher’s exact test where cell counts were ≤ 5. Differences in continuous data were compared using a t-test.

Results

A total of 16 studies were conducted in five sentinel sites, with 459, 505 and 332 children included in 2005, 2007 and 2009, respectively. The PCR-corrected 28-day cure rates using the per-protocol analysis were between 96%-100% for artemether-lumefantrine and 94%-100% for artesunate-amodiaquine.

Conclusions

Both formulations of artemisinin-based combination therapy were effective over time and no severe adverse events related to the treatment were reported during the studies.
Zusatzmaterial
Authors’ original file for figure 1
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