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Neurosurgical Review
Erschienen in: Neurosurgical Review 2/2019

07.05.2018 | Original Article

Survival analysis of patients with spinal chordomas

verfasst von: Hui-Hui Sun, Xin Hong, Bing Liu, Jia-Qu Cui, Zhao-Ming Zhou, Xin-Hui Xie, Xiao-Tao Wu

Erschienen in: Neurosurgical Review | Ausgabe 2/2019

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Abstract

This study was aimed to analyze the survival of patients with spinal chordomas. Patients’ data in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved and analyzed statistically. There were 765 patients with spinal chordomas between 1974 and 2013. The overall survival did not improve significantly over decades for patients receiving surgery and radiotherapy (SR) (P = 0.221). There were significant differences in overall survival among subgroups of patients receiving surgery (S), radiotherapy (R), and neither S nor R (NSR) (P = 0.031, 0.037, and 0.031, respectively). Cancer-specific survival did not change significantly among subgroups of patients receiving R (P = 0.411), while it increased steadily among subgroups of patients receiving S, SR, and NSR (P < 0.001, 0.001, and 0.049, respectively). In the multivariate Cox regression model, younger onset age (hazard ratio [HR] 1.052, P < 0.001), surgery (HR 0.291, P = 0.001), and tumor location of the sacrum (HR 0.401, P = 0.002) were associated with a better overall survival. Similarly, younger onset age (HR 1.036, P = 0.029), surgery (HR 0.221, P = 0.009), and tumor location of the sacrum (HR 0.287, P = 0.002) were also associated with a higher cancer-specific survival. The changes in overall and cancer-specific survival over time differ among different treatment groups. Younger onset age, surgical strategy, and tumor location of the sacrum may be correlated with a higher overall and cancer-specific survival.
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Metadaten
Titel
Survival analysis of patients with spinal chordomas
verfasst von
Hui-Hui Sun
Xin Hong
Bing Liu
Jia-Qu Cui
Zhao-Ming Zhou
Xin-Hui Xie
Xiao-Tao Wu
Publikationsdatum
07.05.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Neurosurgical Review / Ausgabe 2/2019
Print ISSN: 0344-5607
Elektronische ISSN: 1437-2320
DOI
https://doi.org/10.1007/s10143-018-0968-7

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