Erschienen in:
05.11.2018 | Review Article
Survival benefits of additional surgery after non-curative endoscopic resection in patients with early gastric cancer: a meta-analysis
verfasst von:
Debang Li, Haixin Luan, Shijie Wang, Yanming Zhou
Erschienen in:
Surgical Endoscopy
|
Ausgabe 3/2019
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Abstract
Background
The survival benefit of additional surgery after non-curative endoscopic resection of early gastric cancer is a matter of debate. This meta-analysis is intended to draw a convincing conclusion on this issue based on data currently available.
Methods
A systematic review of PubMed/Medline database was performed from 2010 to 2018 for studies comparing survival outcomes of additional surgery versus simple follow-up after non-curative endoscopic resection for early gastric cancer. Differences between groups were calculated using either the fixed effects model or random effects model.
Results
Ten retrospective studies with 4225 patients met the inclusion criteria. Additional surgery significantly provided better 5 years overall survival [odds ratios (OR) 3.50, 95% confidence interval (95% CI) 2.89–4.24] and disease-specific survival (OR 3.99, 95% CI 2.50–6.36).
Conclusions
Additional surgery offers survival benefits to patients undergoing non-curative endoscopic resection of early gastric cancer.