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Annals of Surgical Oncology
Erschienen in:

12.08.2024 | Head and Neck Oncology

Survival Outcome Superiority of Total Pharyngolaryngectomy Compared with Chemoradiotherapy for T4aM0 Hypopharyngeal Squamous Cell Carcinoma: A Nationwide Database Study of Japan

verfasst von: Go Omura, MD, PhD, Kohtaro Eguchi, MD, PhD, Seiichi Yoshimoto, MD, PhD, Yoshitaka Honma, MD, Chihiro Fushimi, DDS, PhD, Toshihiko Sakai, MD, Yoshifumi Matsumoto, MD, PhD, Azusa Sakai, MD, Megumi Kitayama, MSN, Daisuke Kawakita, MD, PhD, Tadaaki Kirita, DDS, PhD, Takeshi Kodaira, MD, PhD, Munenaga Nakamizo, MD, PhD, Ken-ichi Nibu, MD, PhD

Erschienen in: Annals of Surgical Oncology | Ausgabe 12/2024

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Abstract

Background

The purpose of this study is to elucidate whether total pharyngolaryngectomy (TPL) or chemoradiotherapy (CRT) provides a better prognostic outcome in patients with T4aM0 hypopharyngeal carcinoma (HPSCC) using a nationwide database.

Methods

All data were obtained from the Head and Neck Cancer Registry of Japan, and information from patients who were newly diagnosed with T4aM0 HPSCC between 2011 and 2015 was extracted. The primary endpoint was disease-specific survival (DSS), and the secondary endpoint was overall survival (OS). The inverse probability of treatment weighting (IPTW) adjustments was used for survival analyses.

Results

Our cohort included 1143 patients. The TPL and CRT groups included 724 and 419 patients, respectively. Following IPTW adjustments, both the OS and DSS of the TPL group were significantly longer than those of the CRT group (P = .02 and P = .002, respectively).

Conclusions

Survival superiority was demonstrated for patients with T4aM0 HPSCC treated with TPL compared with those treated with CRT.
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Metadaten
Titel
Survival Outcome Superiority of Total Pharyngolaryngectomy Compared with Chemoradiotherapy for T4aM0 Hypopharyngeal Squamous Cell Carcinoma: A Nationwide Database Study of Japan
verfasst von
Go Omura, MD, PhD
Kohtaro Eguchi, MD, PhD
Seiichi Yoshimoto, MD, PhD
Yoshitaka Honma, MD
Chihiro Fushimi, DDS, PhD
Toshihiko Sakai, MD
Yoshifumi Matsumoto, MD, PhD
Azusa Sakai, MD
Megumi Kitayama, MSN
Daisuke Kawakita, MD, PhD
Tadaaki Kirita, DDS, PhD
Takeshi Kodaira, MD, PhD
Munenaga Nakamizo, MD, PhD
Ken-ichi Nibu, MD, PhD
Publikationsdatum
12.08.2024
Verlag
Springer International Publishing
Erschienen in
Annals of Surgical Oncology / Ausgabe 12/2024
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-024-15994-3

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