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Erschienen in: Journal of Anesthesia 5/2016

04.06.2016 | Clinical Report

Switching therapy from intravenous beta blocker to bisoprolol transdermal patch for atrial fibrillation tachycardia

verfasst von: Kensuke Nakamura, Ryota Inokuchi, Takahiro Hiruma, Kurato Tokunaga, Kent Doi, Susumu Nakajima

Erschienen in: Journal of Anesthesia | Ausgabe 5/2016

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Abstract

Beta-blockers are important for severe-status patients with atrial fibrillation-related tachycardia. Beta 1-selective intravenous injection are routinely used, but long-term administration is difficult due to cost-performance- or management-related issues. A bisoprolol patch, a beta-blocker to be percutaneously absorbed, recently became commercially available in Japan. As it may facilitate effective absorption and a mild elevation of the blood concentration, we retrospectively analyzed 16 patients with atrial fibrillation-related tachycardia who were admitted to the Intensive Care Unit of Hitachi General Hospital Emergency and Critical Care Center, and underwent switching therapy from landiolol to a bisoprolol patch. For switching, the bisoprolol patch (4 mg) was attached to each patient. The bisoprolol patch was introduced 88 h after the start of landiolol administration, when the rate was approximately 3 μg/kg/min. Landiolol injection was combined with bisoprolol for 15.4 ± 17.5 h. Switching therapy was successful in all subjects. The introduction of the bisoprolol patch did not induce any significant changes in the blood pressure or heart rate. After the completion of landiolol administration, there were also no significant changes in either parameter. There were no adverse events. In severe-status patients, switching therapy from landiolol injection to the bisoprolol patch can be conducted safely, and might be useful for heart-rate control.
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Metadaten
Titel
Switching therapy from intravenous beta blocker to bisoprolol transdermal patch for atrial fibrillation tachycardia
verfasst von
Kensuke Nakamura
Ryota Inokuchi
Takahiro Hiruma
Kurato Tokunaga
Kent Doi
Susumu Nakajima
Publikationsdatum
04.06.2016
Verlag
Springer Japan
Erschienen in
Journal of Anesthesia / Ausgabe 5/2016
Print ISSN: 0913-8668
Elektronische ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-016-2199-9

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