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Pediatric Surgery International

Erschienen in:

09.04.2018 | Original Article

Symptom development in originally asymptomatic CPAM diagnosed prenatally: a systematic review

verfasst von: Navot Kantor, Carolyn Wayne, Ahmed Nasr

Erschienen in: Pediatric Surgery International | Ausgabe 6/2018

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Abstract

Purpose

For the approximately three quarters of patients with a prenatal diagnosis of congenital pulmonary airway malformation (CPAM) who are asymptomatic at birth, the chance of eventually developing symptoms is unknown. We sought to explore the natural history of asymptomatic CPAM.

Methods

We searched EMBASE, MEDLINE, and the first 50 results from Google Scholar. Studies describing the natural history of prenatally diagnosed, initially asymptomatic CPAM were included. For asymptomatic patients initially managed non-surgically, we tabulated the proportion who went on to develop symptoms as well as the median age at symptom development.

Results

We included data from 19 retrospective studies on 353 patients. Of the 128 patients managed expectantly, 31 (24.2%) developed symptoms requiring surgical intervention. The median age at symptom development was 7.5 months (range 15 days–5 years).

Conclusion

The risk for developing respiratory symptoms exists with originally asymptomatic CPAM patients, but the exact risk is difficult to predict. Parents may be given the value of approximately 1 in 4 as an estimate of the proportion of asymptomatic CPAM patients who go on to develop symptoms, which will help them make an informed decision regarding the option of elective surgery.

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Titel: Symptom development in originally asymptomatic CPAM diagnosed prenatally: a systematic review
verfasst von: Navot Kantor
Carolyn Wayne
Ahmed Nasr
Publikationsdatum: 09.04.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 6/2018
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-018-4264-y

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Symptom development in originally asymptomatic CPAM diagnosed prenatally: a systematic review

Abstract

Purpose

Methods

Results

Conclusion

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Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

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Zunahme von Geschlechtsinkongruenz und -dysphorie registriert

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Update Pädiatrie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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