Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende Patientenratgeber
Erweiterte Suche
Anmelden
nach oben
Archives of Gynecology and Obstetrics
Erschienen in:

10.01.2022 | Gynecologic Oncology

Synchronous/metachronous endometrial and colorectal malignancies in Taiwanese women: a population-based nationwide study

verfasst von: Angel Chao, Ren-Chin Wu, An-Shine Chao, Wei-Yang Chang, Chen-Hsuan Wu, Chyong-Huey Lai, Lan-Yan Yang

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 1/2022

Einloggen, um Zugang zu erhalten

Abstract

Introduction

Endometrial cancer (EC) and colorectal cancer (CRC) may share a common genetic background. In a subset of patients, the two malignancies can coexist either at the time of diagnosis (synchronous) or develop consequently (metachronous). The purpose of this nationwide, population-based study was to investigate the occurrence and clinical outcomes of synchronous/metachronous EC/CRC in Taiwanese women.

Materials and methods

Data for women diagnosed with EC and/or CRC between 2007 and 2015 were retrospectively retrieved from the nationwide Taiwan Cancer Registry. Mortality data were obtained from the National Death Registry. Women with synchronous/metachronous EC/CRC versus EC or CRC were compared in terms of clinical characteristics and outcomes.

Results

Of the 62,764 Taiwanese women diagnosed with EC and/or CRC during the study period, 167 (0.3%) had synchronous/metachronous EC/CRC. Among them, 72 cases (43.1%) presented with EC followed by CRC, 66 (39.5%) with CRC followed by EC, and 29 (17.4%) with synchronous EC/CRC. Kaplan–Meier estimates for time-to-event data revealed that the 2-year risk rates of developing a metachronous tumor of interest (CRC or EC) in women diagnosed with an initial EC and CRC were 39.6% and 42.1%, respectively. The 5-year overall survival rates of women with metachronous EC/CRC who had an initial diagnosis of EC, CRC, and synchronous EC/CRC were 73.9%, 70.9%, and 37.0%, respectively.

Conclusions

Endometrial cancer is the most common first tumor in Taiwanese women with metachronous EC/CRC. The 2-year risk rates of developing a metachronous tumor of interest (CRC or EC) in women diagnosed with an initial EC and CRC are not negligible. Surveillance for CRC is recommended for all women diagnosed with EC. The clinical outcomes of synchronous EC/CRC are markedly less favorable.
Literatur
1.
Lortet-Tieulent J, Ferlay J, Bray F, Jemal A (2018) International patterns and trends in endometrial cancer incidence, 1978–2013. J Natl Cancer Inst 110(4):354–361CrossRef
2.
Siegel RL, Miller KD, Fuchs HE, Jemal A (2021) Cancer statistics, 2021. CA Cancer J Clin 71(1):7–33CrossRef
3.
(2015) Health promotion administration ministry of health and welfare Taiwan. 2012 Cancer registry annual report, Taiwan
4.
(2020) Health promotion administration ministry of health and welfare Taiwan. 2018 Cancer registry annual report, Taiwan
5.
WHO Classification of Tumours Editorial Board. Female genital tumours. Lyon (France): International Agency for Research on Cancer; 2020. (WHO classification of tumours series). http://​publications.​iarc.​fr/​592, vol. 4, 5th edn; 2020
6.
Levine DA (2013) Integrated genomic characterization of endometrial carcinoma. Nature 497(7447):67–73CrossRef
7.
Lynch HT, Snyder CL, Shaw TG, Heinen CD, Hitchins MP (2015) Milestones of lynch syndrome: 1895–2015. Nat Rev Cancer 15(3):181–194CrossRef
8.
Dashti SG, Chau R, Ouakrim DA, Buchanan DD, Clendenning M, Young JP et al (2015) Female hormonal factors and the risk of endometrial cancer in Lynch syndrome. JAMA 314(1):61–71CrossRef
9.
Vasen HF, Watson P, Mecklin JP, Lynch HT (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 116(6):1453–1456CrossRef
10.
Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Ruschoff J et al (2004) Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96(4):261–268CrossRef
11.
Lynch HT, Lynch J (2000) Lynch syndrome: genetics, natural history, genetic counseling, and prevention. J Clin Oncol 18(21 Suppl):19S-31SPubMed
12.
Anagnostopoulos A, McKay VH, Cooper I, Campbell F, Greenhalgh L, Kirwan J (2017) Identifying Lynch syndrome in women presenting with endometrial carcinoma under the age of 50 years. Int J Gynecol Cancer 27(5):931–937CrossRef
13.
Barrow E, Hill J, Evans DG (2013) Cancer risk in Lynch syndrome. Fam Cancer 12(2):229–240CrossRef
14.
Manchana T, Ariyasriwatana C, Triratanachat S, Phowthongkum P (2021) Lynch syndrome in Thai endometrial cancer patients. Asian Pac J Cancer Prev 22(5):1477–1483CrossRef
15.
Jia S, Wu X, Zhang Y, Zhang M (2021) Chinese Lynch syndrome-associated colorectal cancer patients’ self-concept and adherence to surveillance. Eur J Cancer Care (Engl) 30(2):e13379CrossRef
16.
Chiang CJ, Wang YW, Lee WC (2019) Taiwan’s Nationwide Cancer Registry system of 40 years: past, present, and future. J Formos Med Assoc 118(5):856–858CrossRef
17.
Kavuluru R, Hands I, Durbin EB, Witt L (2013) Automatic extraction of ICD-O-3 primary sites from cancer pathology reports. AMIA Jt Summits Transl Sci Proc 2013:112–116PubMedPubMedCentral
18.
Lu TH, Lee MC, Chou MC (2000) Accuracy of cause-of-death coding in Taiwan: types of miscoding and effects on mortality statistics. Int J Epidemiol 29(2):336–343CrossRef
19.
Tibiletti MG, Carnevali I, Calo V, Cini G, Lucci Cordisco E, Remo A et al (2021) Universal testing for MSI/MMR status in colorectal and endometrial cancers to identify Lynch syndrome cases: state of the art in Italy and consensus recommendations from the Italian Association for the Study of Familial Gastrointestinal Tumors (AIFEG). Eur J Cancer Prev
20.
Ryan NA, McMahon RF, Ramchander NC, Seif MW, Evans DG, Crosbie EJ (2021) Lynch syndrome for the gynaecologist. Obstet Gynaecol 23(1):9–20CrossRef
21.
Lee KD, Chen CY, Huang HJ, Wang TY, Teng D, Huang SH et al (2015) Increased risk of second primary malignancies following uterine cancer: a population-based study in Taiwan over a 30-year period. BMC Cancer 15:393CrossRef
22.
Wagner A, Hendriks Y, Meijers-Heijboer EJ, de Leeuw WJ, Morreau H, Hofstra R et al (2001) Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree. J Med Genet 38(5):318–322CrossRef
23.
Hendriks YM, Wagner A, Morreau H, Menko F, Stormorken A, Quehenberger F et al (2004) Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance. Gastroenterology 127(1):17–25CrossRef
24.
Buchanan DD, Tan YY, Walsh MD, Clendenning M, Metcalf AM, Ferguson K et al (2014) Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline mismatch repair gene mutation testing. J Clin Oncol 32(2):90–100CrossRef
25.
Mills AM, Liou S, Ford JM, Berek JS, Pai RK, Longacre TA (2014) Lynch syndrome screening should be considered for all patients with newly diagnosed endometrial cancer. Am J Surg Pathol 38(11):1501–1509CrossRef
26.
Lu KH, Dinh M, Kohlmann W, Watson P, Green J, Syngal S et al (2005) Gynecologic cancer as a “sentinel cancer” for women with hereditary nonpolyposis colorectal cancer syndrome. Obstet Gynecol 105(3):569–574CrossRef
27.
Win AK, Lindor NM, Winship I, Tucker KM, Buchanan DD, Young JP et al (2013) Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome. J Natl Cancer Inst 105(4):274–279CrossRef
28.
Aarnio M, Sankila R, Pukkala E, Salovaara R, Aaltonen LA, de la Chapelle A et al (1999) Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer 81(2):214–218CrossRef
29.
Li X, Liu G, Wu W (2021) Recent advances in Lynch syndrome. Exp Hematol Oncol 10(1):37CrossRef
Metadaten
Titel
Synchronous/metachronous endometrial and colorectal malignancies in Taiwanese women: a population-based nationwide study
verfasst von
Angel Chao
Ren-Chin Wu
An-Shine Chao
Wei-Yang Chang
Chen-Hsuan Wu
Chyong-Huey Lai
Lan-Yan Yang
Publikationsdatum
10.01.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 1/2022
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-021-06296-0

Weitere Artikel der Ausgabe 1/2022

A novel bilateral anterior sacrospinous hysteropexy technique for apical pelvic organ prolapse repair via the vaginal route: a cohort study

  • Open Access
  • General Gynecology

Labor induction in twin pregnancies: Does the perinatal outcome differ according to chorionicity?

  • Maternal-Fetal Medicine

Correction to: Surgery due to mechanical bowel obstruction in relapsed ovarian cancer: clinical and surgical results of a bicentric analysis of 87 patients

  • Open Access
  • Correction

Evaluation of circulating microRNAs as non-invasive biomarkers in the diagnosis of ovarian cancer: a case–control study

  • Open Access
  • Gynecologic Oncology

Comparison the effect of Swedish massage and interferential electrical stimulation on labor pain and childbirth experience in primiparous women: a randomized controlled clinical trial

  • Maternal-Fetal Medicine

Impact of fetal presentation on neurodevelopmental outcome in a trial of preterm vaginal delivery: a nationwide, population-based record linkage study

  • Open Access
  • Maternal-Fetal Medicine

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Einer von sieben Frauen macht die Menopause sehr zu schaffen

Von mäßigen bis schweren vasomotorischen Beschwerden sind 14,7% der Frauen in der Postmenopause betroffen. Das haben kanadische Forscherinnen in einer Subgruppenanalyse der WARM-Studie herausgefunden.

Die elektronische Patientenakte kommt: Das sollten Sie jetzt wissen

Am 15. Januar geht die „ePA für alle“ zunächst in den Modellregionen an den Start. Doch schon bald soll sie in allen Praxen zum Einsatz kommen. Was ist jetzt zu tun? Was müssen Sie wissen? Wir geben in einem FAQ Antworten auf 21 Fragen.

Keine eingeschränkten Kassenleistungen bei Schwangerschaft nach IVF

Nach privat bezahlter In-vitro-Fertilisation muss die gesetzliche Krankenkasse ein Arzneimittel zum Erhalt der Schwangerschaft bezahlen, so ein Urteil des Sozialgerichts in München.

Medikamente verändern wohl Nährstoffzusammensetzung der Muttermilch

Einige Medikamente wie selektive Serotonin-Wiederaufnahmehemmer können offenbar die Makronährstoffzusammensetzung der Muttermilch verändern. Das birgt möglicherweise gesundheitliche Risiken für manche gestillte Kinder.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen
Bildnachweise