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Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy 12/2018

31.03.2018 | Knee

Synergistic activity of platelet rich plasma and high volume image guided injection for patellar tendinopathy

verfasst von: Michele Abate, Luigi Di Carlo, Sandra Verna, Patrizia Di Gregorio, Cosima Schiavone, Vincenzo Salini

Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy | Ausgabe 12/2018

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Abstract

Purpose

Platelet rich plasma and high volume image guided injections of saline have been used in the treatment of patellar tendinopathy with positive results. As the different mechanisms of action do not interfere each other, it can be hypothesized that they can be used in combination. Aim of this study was twofold: first, to evaluate the efficacy of these two treatments in the management of patellar tendinopathy; second, to verify whether the combination of these therapies could provide further advantages.

Methods

Fifty-four patients suffering from patellar tendinopathy were enrolled. After clinical (VAS and VISA-P) and sonographic evaluation, two ultrasound guided injections (2 weeks apart) of platelet rich plasma, high-volume image-guided injections of saline, or both in association were performed. The VAS and VISA-P scores obtained from the three treatments groups (18 patients in each group) were compared across the different follow-up times (3 and 6 months).

Results

In the short term both treatments showed comparable efficacy, whereas in the medium term the positive effects of high-volume image-guided injections gradually diminished and platelet rich plasma showed greater efficacy. Better results (reduced pain, improved function and increased number of subjects who exhibited optimal recovery [> 20 points in VISA-P score]) were observed when both procedures were associated.

Conclusions

The contemporaneous administration of platelet rich plasma and high volume image guided injections of saline treatments, which influence tendon repair by means of different mechanisms, grants a greater improvement for patellar tendinopathy. This finding has clinical relevance, given that this condition has a substantial impact on sports and work performance.

Level of evidence

III.
Literatur
1.
Zurück zum Zitat Abate M, Schiavone C, Pelotti P, Salini V (2011) Limited joint mobility (LJM) in elderly subjects with type II diabetes mellitus. Arch Gerontol Geriatr 53:135–140CrossRef Abate M, Schiavone C, Pelotti P, Salini V (2011) Limited joint mobility (LJM) in elderly subjects with type II diabetes mellitus. Arch Gerontol Geriatr 53:135–140CrossRef
2.
Zurück zum Zitat Abate M, Schiavone C, Salini V, Andia I (2013) Occurrence of tendon pathologies in metabolic disorders. Rheumatology 52:599–608CrossRef Abate M, Schiavone C, Salini V, Andia I (2013) Occurrence of tendon pathologies in metabolic disorders. Rheumatology 52:599–608CrossRef
3.
Zurück zum Zitat Abate M, Di Gregorio P, Schiavone C et al (2012) Platelet rich plasma in tendinopathies: how to explain the failure. Int J Immunopathol Pharmacol 25:325–334CrossRef Abate M, Di Gregorio P, Schiavone C et al (2012) Platelet rich plasma in tendinopathies: how to explain the failure. Int J Immunopathol Pharmacol 25:325–334CrossRef
4.
Zurück zum Zitat Abate M, Silbernagel KG, Siljeholm C et al (2009) Pathogenesis of tendinopathies: inflammation or degeneration? Arthritis Res Ther 11:235–249CrossRef Abate M, Silbernagel KG, Siljeholm C et al (2009) Pathogenesis of tendinopathies: inflammation or degeneration? Arthritis Res Ther 11:235–249CrossRef
5.
Zurück zum Zitat Alfredson H, Ohberg L (2005) Neovascularisation in chronic painful patellar tendinosis—promising results after sclerosing neovessels outside the tendon challenge the need for surgery. Knee Surg Sports Traumatol Arthrosc 3:74–80CrossRef Alfredson H, Ohberg L (2005) Neovascularisation in chronic painful patellar tendinosis—promising results after sclerosing neovessels outside the tendon challenge the need for surgery. Knee Surg Sports Traumatol Arthrosc 3:74–80CrossRef
6.
Zurück zum Zitat Allison GT, Purdam C (2009) Eccentric loading for Achilles tendinopathy—strengthening or stretching? Br J Sports Med 43:276–279CrossRef Allison GT, Purdam C (2009) Eccentric loading for Achilles tendinopathy—strengthening or stretching? Br J Sports Med 43:276–279CrossRef
7.
Zurück zum Zitat Andia I, Abate M (2013) Platelet-rich plasma: underlying biology and clinical correlates. Regen Med 8:645–658CrossRef Andia I, Abate M (2013) Platelet-rich plasma: underlying biology and clinical correlates. Regen Med 8:645–658CrossRef
8.
Zurück zum Zitat Andia I, Latorre PM, Gomez MC et al (2014) Platelet-rich plasma in the conservative treatment of painful tendinopathy: a systematic review and meta-analysis of controlled studies. Br Med Bull 110:99–115CrossRef Andia I, Latorre PM, Gomez MC et al (2014) Platelet-rich plasma in the conservative treatment of painful tendinopathy: a systematic review and meta-analysis of controlled studies. Br Med Bull 110:99–115CrossRef
9.
Zurück zum Zitat Anitua E, Sanchez M, Nurden AT et al (2006) Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A 77:285–293CrossRef Anitua E, Sanchez M, Nurden AT et al (2006) Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A 77:285–293CrossRef
10.
Zurück zum Zitat Barker-Davies RM, Nicol A, McCurdie I et al (2017) Study protocol: a double blind randomised control trial of high volume image guided injections in Achilles and patellar tendinopathy in a young active population. BMC Musculoskelet Disord 18(1):204CrossRef Barker-Davies RM, Nicol A, McCurdie I et al (2017) Study protocol: a double blind randomised control trial of high volume image guided injections in Achilles and patellar tendinopathy in a young active population. BMC Musculoskelet Disord 18(1):204CrossRef
11.
Zurück zum Zitat Bar-Or D, Rael LT, Brody EN (2017) Use of saline as a placebo in intra-articular injections in osteoarthritis: potential contributions to nociceptive pain relief. Open Rheumatol J 11:16–22CrossRef Bar-Or D, Rael LT, Brody EN (2017) Use of saline as a placebo in intra-articular injections in osteoarthritis: potential contributions to nociceptive pain relief. Open Rheumatol J 11:16–22CrossRef
12.
Zurück zum Zitat Bi Y, Ehirchiou D, Kilts TM et al (2007) Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med 13:1219–1227CrossRef Bi Y, Ehirchiou D, Kilts TM et al (2007) Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med 13:1219–1227CrossRef
13.
Zurück zum Zitat Bode G, Hammer T, Karvouniaris N et al (2017) Patellar tendinopathy in young elite soccer—clinical and sonographical analysis of a German elite soccer academy. BMC Musculoskelet Disord 18:344CrossRef Bode G, Hammer T, Karvouniaris N et al (2017) Patellar tendinopathy in young elite soccer—clinical and sonographical analysis of a German elite soccer academy. BMC Musculoskelet Disord 18:344CrossRef
14.
Zurück zum Zitat Boesen AP, Hansen R, Boesen MI et al (2017) Effect of high-volume injection, platelet-rich plasma and sham treatment in chronic midportion Achilles tendinopathy; a randomized double-blinded prospective study. Am J Sports Med 45:2034–2043CrossRef Boesen AP, Hansen R, Boesen MI et al (2017) Effect of high-volume injection, platelet-rich plasma and sham treatment in chronic midportion Achilles tendinopathy; a randomized double-blinded prospective study. Am J Sports Med 45:2034–2043CrossRef
15.
Zurück zum Zitat Cook JL, Malliaras P, De Luca J et al (2005) Vascularity and pain in the patellar tendon of adult jumping athletes: a 5 month longitudinal study. Br J Sports Med 39(7):458–461CrossRef Cook JL, Malliaras P, De Luca J et al (2005) Vascularity and pain in the patellar tendon of adult jumping athletes: a 5 month longitudinal study. Br J Sports Med 39(7):458–461CrossRef
16.
Zurück zum Zitat Crisp T, Khan F, Padhiar N et al (2008) High volume ultrasound guided injections at the interface between the patellar tendon and Hoffa’s body are effective in chronic patellar tendinopathy: a pilot study. Disabil Rehabil 30:1625–1634CrossRef Crisp T, Khan F, Padhiar N et al (2008) High volume ultrasound guided injections at the interface between the patellar tendon and Hoffa’s body are effective in chronic patellar tendinopathy: a pilot study. Disabil Rehabil 30:1625–1634CrossRef
17.
Zurück zum Zitat de Mos M, van der Windt AE, Jahr H et al (2008) Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med 36:1171–1178CrossRef de Mos M, van der Windt AE, Jahr H et al (2008) Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med 36:1171–1178CrossRef
18.
Zurück zum Zitat Dean BJ, Franklin SL, Carr AJ (2013) The peripheral neuronal phenotype is important in the pathogenesis of painful human tendinopathy: a systematic review. Clin Orthop Relat Res 471:3036–3046CrossRef Dean BJ, Franklin SL, Carr AJ (2013) The peripheral neuronal phenotype is important in the pathogenesis of painful human tendinopathy: a systematic review. Clin Orthop Relat Res 471:3036–3046CrossRef
19.
Zurück zum Zitat De Vries AJ, Koolhaas W, Zwerver J et al (2017) The impact of patellar tendinopathy on sports and work performance in active athletes. Res Sports Med 25:253–265CrossRef De Vries AJ, Koolhaas W, Zwerver J et al (2017) The impact of patellar tendinopathy on sports and work performance in active athletes. Res Sports Med 25:253–265CrossRef
20.
Zurück zum Zitat Di Matteo B, Filardo G, Kon E, Marcacci M (2015) Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy—a systematic review. Musculoskelet Surg 99:1–9CrossRef Di Matteo B, Filardo G, Kon E, Marcacci M (2015) Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy—a systematic review. Musculoskelet Surg 99:1–9CrossRef
21.
Zurück zum Zitat Dragoo JL, Wasterlain AS, Braun HJ, Nead KT (2014) Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial. Am J Sports Med 42:610–618CrossRef Dragoo JL, Wasterlain AS, Braun HJ, Nead KT (2014) Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial. Am J Sports Med 42:610–618CrossRef
22.
Zurück zum Zitat Dupley L, Charalambous CP (2017) Platelet-rich plasma injections as a treatment for refractory patellar tendinosis: a meta-analysis of randomised trials. Knee Surg Relat Res 29(3):165–171CrossRef Dupley L, Charalambous CP (2017) Platelet-rich plasma injections as a treatment for refractory patellar tendinosis: a meta-analysis of randomised trials. Knee Surg Relat Res 29(3):165–171CrossRef
23.
Zurück zum Zitat Ferrero G, Fabbro E, Orlandi D et al (2012) Ultrasound-guided injection of platelet-rich plasma in chronic Achilles and patellar tendinopathy. J Ultrasound 15:260–266CrossRef Ferrero G, Fabbro E, Orlandi D et al (2012) Ultrasound-guided injection of platelet-rich plasma in chronic Achilles and patellar tendinopathy. J Ultrasound 15:260–266CrossRef
25.
Zurück zum Zitat Kaux JF, Bruyere O, Croisier JL et al (2015) One-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies. Acta Orthop Belg 81:251–256PubMed Kaux JF, Bruyere O, Croisier JL et al (2015) One-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies. Acta Orthop Belg 81:251–256PubMed
26.
Zurück zum Zitat Khan KM, Maffulli N, Coleman BD et al (1998) Patellar tendinopathy: some aspects of basic science and clinical management. Br J Sports Med 32:346–355CrossRef Khan KM, Maffulli N, Coleman BD et al (1998) Patellar tendinopathy: some aspects of basic science and clinical management. Br J Sports Med 32:346–355CrossRef
27.
Zurück zum Zitat Kıraç FS (2013) Is ethics approval necessary for all trials? A clear but not certain process. Mol Imaging Radionucl Ther 22:73–75CrossRef Kıraç FS (2013) Is ethics approval necessary for all trials? A clear but not certain process. Mol Imaging Radionucl Ther 22:73–75CrossRef
28.
Zurück zum Zitat Kruckeberg BM, Chahla J, Ferrari MB et al (2017) Open patellar tendon tenotomy, debridement, and repair technique augmented with platelet-rich plasma for recalcitrant patellar tendinopathy. Arthrosc Tech 6:e447–e453CrossRef Kruckeberg BM, Chahla J, Ferrari MB et al (2017) Open patellar tendon tenotomy, debridement, and repair technique augmented with platelet-rich plasma for recalcitrant patellar tendinopathy. Arthrosc Tech 6:e447–e453CrossRef
29.
Zurück zum Zitat Lian OB, Engebretsen L, Bahr R (2005) Prevalence of jumper’s knee among elite athletes from different sports: a cross-sectional study. Am J Sports Med 33:561–567CrossRef Lian OB, Engebretsen L, Bahr R (2005) Prevalence of jumper’s knee among elite athletes from different sports: a cross-sectional study. Am J Sports Med 33:561–567CrossRef
30.
Zurück zum Zitat Liddle AD, Rodríguez-Merchán EC (2015) Platelet-rich plasma in the treatment of patellar tendinopathy: a systematic review. Am J Sports Med 43:2583–2590CrossRef Liddle AD, Rodríguez-Merchán EC (2015) Platelet-rich plasma in the treatment of patellar tendinopathy: a systematic review. Am J Sports Med 43:2583–2590CrossRef
31.
Zurück zum Zitat Maffulli N, Del Buono A, Oliva F et al (2016) High-volume image-guided injection for recalcitrant patellar tendinopathy in athletes. Clin J Sport Med 26:12–16CrossRef Maffulli N, Del Buono A, Oliva F et al (2016) High-volume image-guided injection for recalcitrant patellar tendinopathy in athletes. Clin J Sport Med 26:12–16CrossRef
32.
Zurück zum Zitat Maffulli N, Longo UG, Testa V et al (2008) VISA-P score for patellar tendinopathy in males: adaptation to Italian. Disabil Rehabil 30:1621–1624CrossRef Maffulli N, Longo UG, Testa V et al (2008) VISA-P score for patellar tendinopathy in males: adaptation to Italian. Disabil Rehabil 30:1621–1624CrossRef
33.
Zurück zum Zitat Maffulli N, Longo UG (2008) How do eccentric exercises work in tendinopathy? Rheumatology 47:1444–1445CrossRef Maffulli N, Longo UG (2008) How do eccentric exercises work in tendinopathy? Rheumatology 47:1444–1445CrossRef
34.
Zurück zum Zitat Malliaras P, Barton CJ, Reeves ND, Langberg H (2013) Achilles and patellar tendinopathy loading programmes: a systematic review comparing clinical outcomes and identifying potential mechanisms for effectiveness. Sports Med 43:267–286CrossRef Malliaras P, Barton CJ, Reeves ND, Langberg H (2013) Achilles and patellar tendinopathy loading programmes: a systematic review comparing clinical outcomes and identifying potential mechanisms for effectiveness. Sports Med 43:267–286CrossRef
35.
Zurück zum Zitat Morton S, Chan O, King J et al (2014) High volume image-guided injections for patellar tendinopathy: a combined retrospective and prospective case series. Muscles Ligaments Tendons J 4:214–219PubMedPubMedCentral Morton S, Chan O, King J et al (2014) High volume image-guided injections for patellar tendinopathy: a combined retrospective and prospective case series. Muscles Ligaments Tendons J 4:214–219PubMedPubMedCentral
36.
Zurück zum Zitat Ohberg L, Alfredson H (2004) Effects on neovascularisation behind the good results with eccentric training in chronic mid-portion Achilles tendinosis? Knee Surg Sports Traumatol Arthrosc 12:465–470CrossRef Ohberg L, Alfredson H (2004) Effects on neovascularisation behind the good results with eccentric training in chronic mid-portion Achilles tendinosis? Knee Surg Sports Traumatol Arthrosc 12:465–470CrossRef
37.
Zurück zum Zitat Ohberg L, Lorentzon R, Alfredson H (2001) Neovascularisation in Achilles tendons with painful tendinosis but not in normal tendons: an ultrasonographic investigation. Knee Surg Sports Traumatol Arthrosc 9:233–238CrossRef Ohberg L, Lorentzon R, Alfredson H (2001) Neovascularisation in Achilles tendons with painful tendinosis but not in normal tendons: an ultrasonographic investigation. Knee Surg Sports Traumatol Arthrosc 9:233–238CrossRef
38.
Zurück zum Zitat Rompe JD, Nafe B, Furia JP, Maffulli N (2007) Eccentric loading, shock-wave treatment, or a wait-and-see policy for tendinopathy of the main body of tendo Achillis: a randomized controlled trial. Am J Sports Med 35:374–383CrossRef Rompe JD, Nafe B, Furia JP, Maffulli N (2007) Eccentric loading, shock-wave treatment, or a wait-and-see policy for tendinopathy of the main body of tendo Achillis: a randomized controlled trial. Am J Sports Med 35:374–383CrossRef
39.
Zurück zum Zitat Sanli I, Morgan B, van Tilborg F et al (2016) Single injection of platelet-rich plasma (PRP) for the treatment of refractory distal biceps tendonitis: long-term results of a prospective multicenter cohort study. Knee Surg Sports Traumatol Arthrosc 24: 2308–2312CrossRef Sanli I, Morgan B, van Tilborg F et al (2016) Single injection of platelet-rich plasma (PRP) for the treatment of refractory distal biceps tendonitis: long-term results of a prospective multicenter cohort study. Knee Surg Sports Traumatol Arthrosc 24: 2308–2312CrossRef
40.
Zurück zum Zitat Sunding K, Fahlström M, Werner S et al (2016) Evaluation of Achilles and patellar tendinopathy with greyscale ultrasound and colour Doppler: using a four-grade scale. Knee Surg Sports Traumatol Arthrosc 24:1988–1996CrossRef Sunding K, Fahlström M, Werner S et al (2016) Evaluation of Achilles and patellar tendinopathy with greyscale ultrasound and colour Doppler: using a four-grade scale. Knee Surg Sports Traumatol Arthrosc 24:1988–1996CrossRef
41.
Zurück zum Zitat Tempfer H, Wagner A, Gehwolf R et al (2009) Perivascular cells of the supraspinatus tendon express both tendon- and stem cell-related markers. Histochem Cell Biol 131:733–741CrossRef Tempfer H, Wagner A, Gehwolf R et al (2009) Perivascular cells of the supraspinatus tendon express both tendon- and stem cell-related markers. Histochem Cell Biol 131:733–741CrossRef
42.
Zurück zum Zitat Vetrano M, Castorina A, Vulpiani MC et al (2013) Platelet-rich plasma versus focused shock waves in the treatment of jumper’s knee in athletes. Am J Sports Med 41:795–803CrossRef Vetrano M, Castorina A, Vulpiani MC et al (2013) Platelet-rich plasma versus focused shock waves in the treatment of jumper’s knee in athletes. Am J Sports Med 41:795–803CrossRef
43.
Zurück zum Zitat Zayni R, Thaunat M, Fayard JM et al (2015) Platelet-rich plasma as a treatment for chronic patellar tendinopathy: comparison of a single versus two consecutive injections. Muscles Ligaments Tendons J 5:92–98PubMedPubMedCentral Zayni R, Thaunat M, Fayard JM et al (2015) Platelet-rich plasma as a treatment for chronic patellar tendinopathy: comparison of a single versus two consecutive injections. Muscles Ligaments Tendons J 5:92–98PubMedPubMedCentral
44.
Zurück zum Zitat Zwerver J, Bredeweg SW, van den Akker-Scheek I (2011) Prevalence of Jumper’s knee among non-elite athletes from different sports: a cross-sectional survey. Am J Sports Med 39:1984–1988CrossRef Zwerver J, Bredeweg SW, van den Akker-Scheek I (2011) Prevalence of Jumper’s knee among non-elite athletes from different sports: a cross-sectional survey. Am J Sports Med 39:1984–1988CrossRef
Metadaten
Titel
Synergistic activity of platelet rich plasma and high volume image guided injection for patellar tendinopathy
verfasst von
Michele Abate
Luigi Di Carlo
Sandra Verna
Patrizia Di Gregorio
Cosima Schiavone
Vincenzo Salini
Publikationsdatum
31.03.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Knee Surgery, Sports Traumatology, Arthroscopy / Ausgabe 12/2018
Print ISSN: 0942-2056
Elektronische ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-018-4930-6

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