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Erschienen in: Seminars in Immunopathology 4/2017

11.05.2017 | Review

Synovial cellular and molecular markers in rheumatoid arthritis

verfasst von: M. Asif Amin, David A. Fox, Jeffrey H. Ruth

Erschienen in: Seminars in Immunopathology | Ausgabe 4/2017

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Abstract

The profound alterations in the structure, cellular composition, and function of synovial tissue in rheumatoid arthritis (RA) are the basis for the persistent inflammation and cumulative joint destruction that are hallmarks of this disease. In RA, the synovium develops characteristics of a tertiary lymphoid organ, with extensive infiltration of lymphocytes and myeloid cells. Concurrently, the fibroblast-like synoviocytes undergo massive hyperplasia and acquire a tissue-invasive phenotype. In this review, we summarize key components of these processes, focusing on recently-described roles of selected molecular markers of these cellular components of RA synovitis.
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Metadaten
Titel
Synovial cellular and molecular markers in rheumatoid arthritis
verfasst von
M. Asif Amin
David A. Fox
Jeffrey H. Ruth
Publikationsdatum
11.05.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Seminars in Immunopathology / Ausgabe 4/2017
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-017-0631-3

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