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Cancer and Metastasis Reviews

Erschienen in:

01.09.2015 | Clinical

Synovial sarcoma is a gateway to the role of chromatin remodeling in cancer

verfasst von: Stefan K. Zöllner, Claudia Rössig, Jeffrey A. Toretsky

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 3/2015

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Abstract

Patients afflicted with synovial sarcoma share the fate of other translocation positive sarcomas; the driver mutation for this cancer is known, yet no means to target the fusion protein SS18-SSX directly exist. Current chemotherapeutic regimens are minimally beneficial, particularly in patients with metastatic disease. SS18-SSX putatively promotes its oncogenic activity through protein-protein interactions that alter genetic programs through chromatin remodeling. This review discusses the functional protein network of SS18-SSX, both wild-type and fusion protein, considers its intrinsically disordered nature, and provides insights into potential therapeutic strategies. A comprehensive overview of the clinical characteristics reveals the need for newly targeted therapeutics based upon oncogenic transformation by the fusion protein SS18-SSX. The wild-type, non-fused proteins SS18 and SSX are presented including their molecular structure and biological function with regard to protein-protein interactions. The interactions of the wild-type proteins inform the oncogenic changes of the fusion protein. The SS18-SSX fusion protein and its protein interactions are described and evaluated for their biological consequences that lead to oncogenesis. This review illustrates the key protein interactions of SS18-SSX that may qualify as primary targets for small molecule-based disruption leading to the development of SS18-SSX-specific drugs. These novel targeted therapeutics may provide a specificity that ultimately improves survival while reducing morbidity of patients with synovial sarcoma.

Dillon, P., et al. (1992). A prospective study of nonrhabdomyosarcoma soft tissue sarcomas in the pediatric age group. Journal of Pediatric Surgery, 27(2), 241–244.

McGrory, J. E., et al. (2000). Nonrhabdomyosarcoma soft tissue sarcomas in children. The Mayo Clinic experience. Clinical Orthopaedics and Related Research, 374, 247–258.PubMedCrossRef

Herzog, C. E. (2005). Overview of sarcomas in the adolescent and young adult population. Journal of Pediatric Hematology/Oncology, 27(4), 215–218.PubMedCrossRef

Raney, R. B. (2005). Synovial sarcoma in young people: background, prognostic factors, and therapeutic questions. Journal of Pediatric Hematology/Oncology, 27(4), 207–211.PubMedCrossRef

Weiss, S. (2008). Enzinger and Weiss’s soft tissue tumors (pp. 1161–1182). St. Louis: Mosby Inc.

Simon, G. (1865). Exstirpation einer sehr grossen, mit dicken Stiele angewachsenen Kneigelenkmaus mit gluklichem Erfolge. Arch Klin Chir, 6, 573–576.

Sabrazes, J., Loubat, E., de Grailly, R., & Magendie, J. (1934). Synovial sarcomes. Gaz Hebd Sc Med Bordeaux, 55, 754–762.

Ghadially, F. N. (1987). Is synovial sarcoma a carcinosarcoma of connective tissue? Ultrastructural Pathology, 11(2–3), 147–151.PubMedCrossRef

Smith, M. E., et al. (1995). Synovial sarcoma lack synovial differentiation. Histopathology, 26(3), 279–281.PubMedCrossRef

10.

Garcia, C. B., et al. (2012). Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT-SSX2. Oncogene, 31(18), 2323–2334.PubMedCentralPubMedCrossRef

11.

Hayakawa, K., et al. (2013). Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells. Biochemical and Biophysical Research Communications, 432(4), 713–719.PubMedCrossRef

12.

Naka, N., et al. (2010). Synovial sarcoma is a stem cell malignancy. Stem Cells, 28(7), 1119–1131.PubMed

13.

Falkenstern-Ge, R.F., et al. (2013) Primary pulmonary synovial sarcoma: a rare primary pulmonary tumor. Lung, 192(1), 211–4.

14.

Wang, J. G., & Li, N. N. (2013). Primary cardiac synovial sarcoma. Annals of Thoracic Surgery, 95(6), 2202–2209.PubMedCrossRef

15.

Schoolmeester, J. K., Cheville, J. C., & Folpe, A. L. (2014). Synovial sarcoma of the kidney: a clinicopathologic, immunohistochemical, and molecular genetic study of 16 cases. American Journal of Surgical Pathology, 38(1), 60–65.PubMedCrossRef

16.

Billings, S. D., et al. (2000). Synovial sarcoma of the upper digestive tract: a report of two cases with demonstration of the X;18 translocation by fluorescence in situ hybridization. Modern Pathology, 13(1), 68–76.PubMedCrossRef

17.

Hiraga, H., et al. (1999). Histological and molecular evidence of synovial sarcoma of bone. A case report. Journal of Bone and Joint Surgery (American), 81(4), 558–563.

18.

Haldar, M., et al. (2007). A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell, 11(4), 375–388.PubMedCrossRef

19.

Haldar, M., et al. (2009). A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice. Cancer Research, 69(8), 3657–3664.PubMedCentralPubMedCrossRef

20.

Bakri, A., et al. (2012). Synovial sarcoma: imaging features of common and uncommon primary sites, metastatic patterns, and treatment response. AJR. American Journal of Roentgenology, 199(2), W208–W215.PubMedCrossRef

21.

Jaganathan, S., et al. (2012). Spectrum of synovial pathologies: a pictorial assay. Current Problems in Diagnostic Radiology, 41(1), 30–42.PubMedCrossRef

22.

Spillane, A. J., et al. (2000). Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. Journal of Clinical Oncology, 18(22), 3794–3803.PubMed

23.

Siegel, H. J., et al. (2007). Synovial sarcoma: clinicopathologic features, treatment, and prognosis. Orthopedics, 30(12), 1020–1025.

24.

Saito, T., Nagai, M., & Ladanyi, M. (2006). SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma. Cancer Research, 66(14), 6919–6927.PubMedCrossRef

25.

Su, L., et al. (2012). Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell, 21(3), 333–347.PubMedCentralPubMedCrossRef

26.

Waterfall, J. J., & Meltzer, P. S. (2012). Targeting epigenetic misregulation in synovial sarcoma. Cancer Cell, 21(3), 323–324.PubMedCrossRef

27.

Miettinen, M., et al. (1999). Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis. Human Pathology, 30(8), 934–942.PubMedCrossRef

28.

van de Rijn, M., et al. (1999). Poorly differentiated synovial sarcoma: an analysis of clinical, pathologic, and molecular genetic features. American Journal of Surgical Pathology, 23(1), 106–112.PubMedCrossRef

29.

Folpe, A. L., et al. (1998). Poorly differentiated synovial sarcoma: immunohistochemical distinction from primitive neuroectodermal tumors and high-grade malignant peripheral nerve sheath tumors. American Journal of Surgical Pathology, 22(6), 673–682.PubMedCrossRef

30.

Sato, O., et al. (2005). Expression of epidermal growth factor receptor, ERBB2 and KIT in adult soft tissue sarcomas: a clinicopathologic study of 281 cases. Cancer, 103(9), 1881–1890.PubMedCrossRef

31.

Teng, H. W., et al. (2011). Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma. Journal of Surgical Oncology, 103(8), 773–781.PubMedCrossRef

32.

Ray, A., & Huh, W. W. (2012). Current state-of-the-art systemic therapy for pediatric soft tissue sarcomas. Current Oncology Reports, 14(4), 311–319.PubMedCrossRef

33.

Shi, W., et al. (2013). Long-term treatment outcomes for patients with synovial sarcoma: a 40-year experience at the University of Florida. American Journal of Clinical Oncology, 36(1), 83–88.PubMedCrossRef

34.

Ferrari, A., et al. (2012). Synovial sarcoma in children and adolescents: a critical reappraisal of staging investigations in relation to the rate of metastatic involvement at diagnosis. European Journal of Cancer, 48(9), 1370–1375.PubMedCrossRef

35.

Tunn, P. U., et al. (2008). Sentinel node biopsy in synovial sarcoma. European Journal of Surgical Oncology, 34(6), 704–707.PubMedCrossRef

36.

Sultan, I., et al. (2009). Comparing children and adults with synovial sarcoma in the Surveillance, Epidemiology, and End Results program, 1983 to 2005: an analysis of 1268 patients. Cancer, 115(15), 3537–3547.PubMedCrossRef

37.

Lagarde, P., et al. (2013). Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas. Journal of Clinical Oncology, 31(5), 608–615.PubMedCrossRef

38.

Dantonello, T. M., et al. (2009). Cooperative trial CWS-91 for localized soft tissue sarcoma in children, adolescents, and young adults. Journal of Clinical Oncology, 27(9), 1446–1455.PubMedCrossRef

39.

Palmerini, E., et al. (2009). Synovial sarcoma: retrospective analysis of 250 patients treated at a single institution. Cancer, 115(13), 2988–2998.PubMedCrossRef

40.

Andrassy, R. J., et al. (2001). Synovial sarcoma in children: surgical lessons from a single institution and review of the literature. Journal of the American College of Surgeons, 192(3), 305–313.PubMedCrossRef

41.

Brecht, I. B., et al. (2006). Grossly-resected synovial sarcoma treated by the German and Italian Pediatric Soft Tissue Sarcoma Cooperative Groups: discussion on the role of adjuvant therapies. Pediatric Blood & Cancer, 46(1), 11–17.CrossRef

42.

Chen, L., et al. (2012). Cancer/testis antigen SSX2 enhances invasiveness in MCF-7 cells by repressing ERalpha signaling. International Journal of Oncology, 40(6), 1986–1994.PubMed

43.

Guillou, L., et al. (2004). Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis. Journal of Clinical Oncology, 22(20), 4040–4050.PubMedCrossRef

44.

Ladenstein, R., et al. (1993). Synovial sarcoma of childhood and adolescence. Report of the German CWS-81 study. Cancer, 71(11), 3647–3655.PubMedCrossRef

45.

Okcu, M. F., et al. (2003). Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome. Journal of Clinical Oncology, 21(8), 1602–1611.PubMedCrossRef

46.

Pappo, A. S., et al. (1994). Synovial sarcoma in children and adolescents: the St Jude Children’s Research Hospital experience. Journal of Clinical Oncology, 12(11), 2360–2366.PubMed

47.

Guadagnolo, B. A., et al. (2007). Long-term outcomes for synovial sarcoma treated with conservation surgery and radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 69(4), 1173–1180.PubMedCrossRef

48.

Krieg, A. H., et al. (2011). Synovial sarcomas usually metastasize after >5 years: a multicenter retrospective analysis with minimum follow-up of 10 years for survivors. Annals of Oncology, 22(2), 458–467.PubMedCrossRef

49.

Bergh, P., et al. (1999). Synovial sarcoma: identification of low and high risk groups. Cancer, 85(12), 2596–2607.PubMedCrossRef

50.

Ferrari, A., et al. (2012). Salvage rates and prognostic factors after relapse in children and adolescents with initially localised synovial sarcoma. European Journal of Cancer, 48(18), 3448–3455.PubMedCrossRef

51.

Amary, M. F., Diss, T. C., & Flanagan, A. M. (2007). Molecular characterization of a novel variant of a SYT-SSX1 fusion transcript in synovial sarcoma. Histopathology, 51(4), 559–561.PubMedCrossRef

52.

Jagdis, A., et al. (2009). Prospective evaluation of TLE1 as a diagnostic immunohistochemical marker in synovial sarcoma. American Journal of Surgical Pathology, 33(12), 1743–1751.PubMedCrossRef

53.

Ladanyi, M., et al. (2002). Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Research, 62(1), 135–140.PubMed

54.

Przybyl, J., et al. (2012). Recurrent and novel SS18-SSX fusion transcripts in synovial sarcoma: description of three new cases. Tumour Biology, 33(6), 2245–2253.PubMedCentralPubMedCrossRef

55.

Smith, H. A., & McNeel, D. G. (2010). The SSX family of cancer-testis antigens as target proteins for tumor therapy. Clinical and Developmental Immunology, 2010, 150591.PubMedCentralPubMedCrossRef

56.

Brodin, B., et al. (2001). Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression. Gene, 268(1–2), 173–182.PubMedCrossRef

57.

Skytting, B., et al. (1999). A novel fusion gene, SYT-SSX4, in synovial sarcoma. Journal of the National Cancer Institute, 91(11), 974–975.PubMedCrossRef

58.

Kadoch, C., & Crabtree, G. R. (2013). Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell, 153(1), 71–85.PubMedCentralPubMedCrossRef

59.

Wei, Y., et al. (2003). Characteristic sequence motifs located at the genomic breakpoints of the translocation t(X;18) in synovial sarcomas. Oncogene, 22(14), 2215–2222.PubMedCrossRef

60.

Kanoe, H., et al. (1999). Characteristics of genomic breakpoints in TLS-CHOP translocations in liposarcomas suggest the involvement of Translin and topoisomerase II in the process of translocation. Oncogene, 18(3), 721–729.PubMedCrossRef

61.

Zucman-Rossi, J., et al. (1998). Chromosome translocation based on illegitimate recombination in human tumors. Proceedings of the National Academy of Sciences of the United States of America, 95(20), 11786–11791.PubMedCentralPubMedCrossRef

62.

Sandberg, A. A., & Bridge, J. A. (2002). Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma. Cancer Genetics and Cytogenetics, 133(1), 1–23.PubMedCrossRef

63.

Nagai, M., et al. (2001). Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha. Proceedings of the National Academy of Sciences of the United States of America, 98(7), 3843–3848.PubMedCentralPubMedCrossRef

64.

Limon, J., Dal Cin, P., & Sandberg, A. A. (1986). Translocations involving the X chromosome in solid tumors: presentation of two sarcomas with t(X;18)(q13;p11). Cancer Genetics and Cytogenetics, 23(1), 87–91.PubMedCrossRef

65.

Turc-Carel, C., et al. (1986). Translocation X;18 in synovial sarcoma. Cancer Genetics and Cytogenetics, 23(1), 93.PubMedCrossRef

66.

Sun, B., et al. (2006). Extent, relationship and prognostic significance of apoptosis and cell proliferation in synovial sarcoma. European Journal of Cancer Prevention, 15(3), 258–265.PubMedCrossRef

67.

Bozzi, F., et al. (2008). Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. Translational Oncology, 1(2), 95–101.PubMedCentralPubMedCrossRef

68.

Horvai, A. E., Kramer, M. J., & O’Donnell, R. (2006). Beta-catenin nuclear expression correlates with cyclin D1 expression in primary and metastatic synovial sarcoma: a tissue microarray study. Archives of Pathology and Laboratory Medicine, 130(6), 792–798.PubMed

69.

Pretto, D., et al. (2006). The synovial sarcoma translocation protein SYT-SSX2 recruits beta-catenin to the nucleus and associates with it in an active complex. Oncogene, 25(26), 3661–3669.PubMedCrossRef

70.

Ishibe, T., et al. (2005). Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy. Clinical Cancer Research, 11(7), 2702–2712.PubMedCrossRef

71.

Barco, R., et al. (2007). The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway. Molecular Biology of the Cell, 18(10), 4003–4012.PubMedCentralPubMedCrossRef

72.

Jones, K. B., et al. (2013). SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. Oncogene, 32(18), 2365–2371.

73.

Mancuso, T., et al. (2000). Analysis of SYT-SSX fusion transcripts and bcl-2 expression and phosphorylation status in synovial sarcoma. Laboratory Investigation, 80(6), 805–813.PubMedCrossRef

74.

de Bruijn, D. R., et al. (1996). Isolation and characterization of the mouse homolog of SYT, a gene implicated in the development of human synovial sarcomas. Oncogene, 13(3), 643–648.PubMed

75.

Clark, J., et al. (1994). Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nature Genetics, 7(4), 502–508.PubMedCrossRef

76.

Thaete, C., et al. (1999). Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. Human Molecular Genetics, 8(4), 585–591.PubMedCrossRef

77.

Brett, D., et al. (1997). The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. Human Molecular Genetics, 6(9), 1559–1564.PubMedCrossRef

78.

dos Santos, N. R., et al. (1997). Nuclear localization of SYT, SSX and the synovial sarcoma-associated SYT-SSX fusion proteins. Human Molecular Genetics, 6(9), 1549–1558.PubMedCrossRef

79.

Toretsky, J. A., & Wright, P. E. (2014). Assemblages: functional units formed by cellular phase separation. Journal of Cell Biology, 206(5), 579–588.PubMedCentralPubMedCrossRef

80.

de Bruijn, D. R., et al. (2001). The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10. Oncogene, 20(25), 3281–3289.PubMedCrossRef

81.

Eid, J. E., et al. (2000). p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion. Cell, 102(6), 839–848.PubMedCrossRef

82.

Ito, T., et al. (2004). SYT, a partner of SYT-SSX oncoprotein in synovial sarcomas, interacts with mSin3A, a component of histone deacetylase complex. Laboratory Investigation, 84(11), 1484–1490.PubMedCrossRef

83.

Middeljans, E., et al. (2012). SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes. PLoS One, 7(3), e33834.PubMedCentralPubMedCrossRef

84.

Wang, X., Haswell, J. R., & Roberts, C. W. (2014). Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer—mechanisms and potential therapeutic insights. Clinical Cancer Research, 20(1), 21–27.PubMedCentralPubMedCrossRef

85.

Wang, F., Marshall, C. B., & Ikura, M. (2013). Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition. Cellular and Molecular Life Sciences, 70(21), 3989–4008.PubMedCrossRef

86.

Wang, W., et al. (1996). Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO Journal, 15(19), 5370–5382.PubMedCentralPubMed

87.

Wang, W., et al. (1996). Diversity and specialization of mammalian SWI/SNF complexes. Genes and Development, 10(17), 2117–2130.PubMedCrossRef

88.

Perani, M., et al. (2003). Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers. Oncogene, 22(50), 8156–8167.PubMedCrossRef

89.

Debernardi, S., et al. (2002). The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. Blood, 99(1), 275–281.PubMedCrossRef

90.

Okada, Y., et al. (2005). hDOT1L links histone methylation to leukemogenesis. Cell, 121(2), 167–178.PubMedCrossRef

91.

Bannister, A. J., & Kouzarides, T. (1996). The CBP co-activator is a histone acetyltransferase. Nature, 384(6610), 641–643.PubMedCrossRef

92.

Ogryzko, V. V., et al. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell, 87(5), 953–959.PubMedCrossRef

93.

Shiama, N. (1997). The p300/CBP family: integrating signals with transcription factors and chromatin. Trends in Cell Biology, 7(6), 230–236.PubMedCrossRef

94.

Huang, Z. Q., et al. (2003). A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription. EMBO Journal, 22(9), 2146–2155.PubMedCentralPubMedCrossRef

95.

Leo, C., & Chen, J. D. (2000). The SRC family of nuclear receptor coactivators. Gene, 245(1), 1–11.PubMedCrossRef

96.

Xu, J., & Li, Q. (2003). Review of the in vivo functions of the p160 steroid receptor coactivator family. Molecular Endocrinology, 17(9), 1681–1692.PubMedCrossRef

97.

McKenna, N. J., Lanz, R. B., & O’Malley, B. W. (1999). Nuclear receptor coregulators: cellular and molecular biology. Endocrine Reviews, 20(3), 321–344.PubMed

98.

Nan, X., et al. (1998). Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature, 393(6683), 386–389.PubMedCrossRef

99.

Nakamura, T., et al. (2002). ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Molecular Cell, 10(5), 1119–1128.PubMedCrossRef

100.

Silverstein, R. A., & Ekwall, K. (2005). Sin3: a flexible regulator of global gene expression and genome stability. Current Genetics, 47(1), 1–17.PubMedCrossRef

101.

Kato, H., et al. (2002). SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. Journal of Biological Chemistry, 277(7), 5498–5505.PubMedCrossRef

102.

Kato, M., et al. (2012). Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell, 149(4), 753–767.PubMedCrossRef

103.

Perani, M., et al. (2005). The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins. Journal of Biological Chemistry, 280(52), 42863–42876.PubMedCrossRef

104.

Iwasaki, T., Chin, W. W., & Ko, L. (2001). Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). Journal of Biological Chemistry, 276(36), 33375–33383.PubMedCrossRef

105.

Auboeuf, D., et al. (2004). CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing. Molecular and Cellular Biology, 24(1), 442–453.PubMedCentralPubMedCrossRef

106.

Auboeuf, D., et al. (2002). Coordinate regulation of transcription and splicing by steroid receptor coregulators. Science, 298(5592), 416–419.PubMedCrossRef

107.

Tamborini, E., et al. (2001). Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma. British Journal of Cancer, 84(8), 1087–1094.PubMedCentralPubMedCrossRef

108.

de Leeuw, B., Balemans, M., & Geurts van Kessel, A. (1996). A novel Kruppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas. Cytogenetics and Cell Genetics, 73(3), 179–183.PubMedCrossRef

109.

dos Santos, N. R., et al. (2000). Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. Cancer Research, 60(6), 1654–1662.PubMed

110.

Gure, A. O., et al. (1997). SSX: a multigene family with several members transcribed in normal testis and human cancer. International Journal of Cancer, 72(6), 965–971.CrossRef

111.

de Bruijn, D. R., et al. (2008). The C terminus of the synovial sarcoma-associated SSX proteins interacts with the LIM homeobox protein LHX4. Oncogene, 27(5), 653–662.PubMedCrossRef

112.

Crew, A. J., et al. (1995). Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO Journal, 14(10), 2333–2340.PubMedCentralPubMed

113.

Gure, A. O., et al. (2002). The SSX gene family: characterization of 9 complete genes. International Journal of Cancer, 101(5), 448–453.CrossRef

114.

dos Santos, N. R., de Bruijn, D. R., & van Kessel, A. G. (2001). Molecular mechanisms underlying human synovial sarcoma development. Genes, Chromosomes & Cancer, 30(1), 1–14.CrossRef

115.

Naka, N., et al. (2002). Expression of SSX genes in human osteosarcomas. International Journal of Cancer, 98(4), 640–642.CrossRef

116.

Mischo, A., et al. (2006). Prospective study on the expression of cancer testis genes and antibody responses in 100 consecutive patients with primary breast cancer. International Journal of Cancer, 118(3), 696–703.CrossRef

117.

Taylor, B. J., et al. (2005). SSX cancer testis antigens are expressed in most multiple myeloma patients: co-expression of SSX1, 2, 4, and 5 correlates with adverse prognosis and high frequencies of SSX-positive PCs. Journal of Immunotherapy, 28(6), 564–575.PubMedCrossRef

118.

Cronwright, G., et al. (2005). Cancer/testis antigen expression in human mesenchymal stem cells: down-regulation of SSX impairs cell migration and matrix metalloproteinase 2 expression. Cancer Research, 65(6), 2207–2215.PubMedCrossRef

119.

dos Santos, N. R., et al. (2000). Delineation of the protein domains responsible for SYT, SSX, and SYT-SSX nuclear localization. Experimental Cell Research, 256(1), 192–202.PubMedCrossRef

120.

Soulez, M., et al. (1999). SSX and the synovial-sarcoma-specific chimaeric protein SYT-SSX co-localize with the human Polycomb group complex. Oncogene, 18(17), 2739–2746.PubMedCrossRef

121.

Huntley, S., et al. (2006). A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors. Genome Research, 16(5), 669–677.PubMedCentralPubMedCrossRef

122.

Vogel, M. J., et al. (2006). Human heterochromatin proteins form large domains containing KRAB-ZNF genes. Genome Research, 16(12), 1493–1504.PubMedCentralPubMedCrossRef

123.

de Bruijn, D. R., et al. (2002). The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. Genes, Chromosomes & Cancer, 34(3), 285–298.CrossRef

124.

Lim, F. L., et al. (1998). A KRAB-related domain and a novel transcription repression domain in proteins encoded by SSX genes that are disrupted in human sarcomas. Oncogene, 17(15), 2013–2018.PubMedCrossRef

125.

Schuettengruber, B., et al. (2007). Genome regulation by polycomb and trithorax proteins. Cell, 128(4), 735–745.PubMedCrossRef

126.

Schwartz, Y. B., & Pirrotta, V. (2007). Polycomb silencing mechanisms and the management of genomic programmes. Nature Reviews Genetics, 8(1), 9–22.PubMedCrossRef

127.

Di Croce, L., & Helin, K. (2013). Transcriptional regulation by Polycomb group proteins. Nature Structural and Molecular Biology, 20(10), 1147–1155.PubMedCrossRef

128.

Wang, J., et al. (2013). Subnuclear distribution of SSX regulates its function. Molecular and Cellular Biochemistry, 381(1–2), 17–29.PubMedCrossRef

129.

Dong, W. F., et al. (1997). Cloning, expression, and chromosomal localization to 11p12-13 of a human LIM/HOMEOBOX gene, hLim-1. DNA and Cell Biology, 16(6), 671–678.PubMed

130.

Kawamata, N., et al. (2002). A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4. Oncogene, 21(32), 4983–4991.PubMedCrossRef

131.

Wu, H. K., & Minden, M. D. (1997). Transcriptional activation of human LIM-HOX gene, hLH-2, in chronic myelogenous leukemia is due to a cis-acting effect of Bcr-Abl. Biochemical and Biophysical Research Communications, 233(3), 806–812.PubMedCrossRef

132.

Yamaguchi, M., Yamamoto, K., & Miura, O. (2003). Aberrant expression of the LHX4 LIM-homeobox gene caused by t(1;14)(q25;q32) in chronic myelogenous leukemia in biphenotypic blast crisis. Genes, Chromosomes & Cancer, 38(3), 269–273.CrossRef

133.

Cironi, L., et al. (2009). Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1. PLoS One, 4(11), e7904.PubMedCentralPubMedCrossRef

134.

Kia, S. K., et al. (2008). SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Molecular and Cellular Biology, 28(10), 3457–3464.PubMedCentralPubMedCrossRef

135.

Wilson, W. H., et al. (2010). Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity. The Lancet Oncology, 11(12), 1149–1159.PubMedCentralPubMedCrossRef

136.

Francis, N. J., Kingston, R. E., & Woodcock, C. L. (2004). Chromatin compaction by a polycomb group protein complex. Science, 306(5701), 1574–1577.PubMedCrossRef

137.

Bantignies, F., & Cavalli, G. (2011). Polycomb group proteins: repression in 3D. Trends in Genetics, 27(11), 454–464.PubMedCrossRef

138.

Mousavi, K., et al. (2012). Polycomb protein Ezh1 promotes RNA polymerase II elongation. Molecular Cell, 45(2), 255–262.PubMedCrossRef

139.

Wilson, B. G., et al. (2010). Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell, 18(4), 316–328.PubMedCentralPubMedCrossRef

140.

Chen, Y., et al. (2008). The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. Journal of Biological Chemistry, 283(26), 17969–17978.PubMedCrossRef

141.

Tan, J. Z., et al. (2014). EZH2: biology, disease, and structure-based drug discovery. Acta Pharmacologica Sinica, 35(2), 161–174.PubMedCentralPubMedCrossRef

142.

Margueron, R., & Reinberg, D. (2011). The Polycomb complex PRC2 and its mark in life. Nature, 469(7330), 343–349.PubMedCentralPubMedCrossRef

143.

Changchien, Y. C., et al. (2012). Poorly differentiated synovial sarcoma is associated with high expression of enhancer of zeste homologue 2 (EZH2). Journal of Translational Medicine, 10, 216.PubMedCentralPubMedCrossRef

144.

Lubieniecka, J. M., et al. (2008). Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma. Cancer Research, 68(11), 4303–4310.PubMedCrossRef

145.

Garcia, C. B., Shaffer, C. M., & Eid, J. E. (2012). Genome-wide recruitment to Polycomb-modified chromatin and activity regulation of the synovial sarcoma oncogene SYT-SSX2. BMC Genomics, 13(1), 189.PubMedCentralPubMedCrossRef

146.

Howard, P. W., & Maurer, R. A. (2000). Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors. Journal of Biological Chemistry, 275(18), 13336–13342.PubMedCrossRef

147.

Ali, S. A., et al. (2010). Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes. Proceedings of the National Academy of Sciences of the United States of America, 107(9), 4165–4169.PubMedCentralPubMedCrossRef

148.

Kawasaki, H., et al. (2000). ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. Nature, 405(6783), 195–200.PubMedCrossRef

149.

Bhoumik, A., & Ronai, Z. (2008). ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities. Cell Cycle, 7(15), 2341–2345.PubMedCrossRef

150.

Lau, E., & Ronai, Z. A. (2012). ATF2 - at the crossroad of nuclear and cytosolic functions. Journal of Cell Science, 125(Pt 12), 2815–2824.PubMedCentralPubMedCrossRef

151.

Erkizan, H. V., et al. (2009). A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing’s sarcoma. Nature Medicine, 15(7), 750–756.PubMedCentralPubMedCrossRef

Titel: Synovial sarcoma is a gateway to the role of chromatin remodeling in cancer
verfasst von: Stefan K. Zöllner
Claudia Rössig
Jeffrey A. Toretsky
Publikationsdatum: 01.09.2015
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 3/2015
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-015-9575-z

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Springer Medizin

Synovial sarcoma is a gateway to the role of chromatin remodeling in cancer

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