Skip to main content
Erschienen in:

06.07.2022 | Review article

Systematic review and meta-analysis of reports of patients with gastric cancer aged 80 years and older

verfasst von: Chihiro Onagi, Mari Oba, Yoko Oshima, Hideaki Shimada

Erschienen in: International Cancer Conference Journal | Ausgabe 4/2022

Einloggen, um Zugang zu erhalten

Abstract

The number of elderly patients in gastric cancer surgery is rapidly rising. Almost all data on gastric cancer in people over the age of 80 come from a single institution, and there is no systematic review of a large number of patients. Therefore, we conducted a comprehensive analysis of the prognosis of patients with gastric cancer surgery who were aged 80 years or older. From January 2010 to November 2021, reports on gastric cancer in the elderly aged 80 and over were gathered. We searched PubMed for “Gastric cancer and elderly and 80 years old” as a keyword, and 253 reports were extracted. The Ichushi-Web database was also searched using the phrase “stomach cancer and 80 years old,” and 366 records were found. The random-effect model was used to determine the average 5-year survival rate, and the heterogeneity was evaluated. The proportion of male patients, patients who had surgery after 2010, patients with stage I, total gastrectomy, lymph node dissection, and the presence of complications were used as the explanatory variables in meta-regressions to investigate the cause of prognosis variability. More than 50 surgical cases were reported, 8 from PubMed and 2 from the Ichushi-Web database, with information on surgical procedures, prognosis, and complications, in a total of 1182 patients. Of the ten reports, eight were from Japan and two were from South Korea and Taiwan. The number of patients ranged from 55 to 217, with an average 5-year survival rate of 57%. In terms of the relationship between the time of surgery and prognosis, the overall prognosis for patients who had surgery before 2010 and those who had surgery after 2010 was almost similar. Reports with a high proportion of stage I showed a good prognosis. The rate of total gastrectomy, the proportion of lymph node dissection above D1 + , or surgical complications had no effect on prognosis. Patients with gastric cancer aged 80 years or older who underwent radical surgery had a 5-year survival rate of up to 57%. Postoperative complications appeared to have a minor impact.
Literatur
2.
Zurück zum Zitat Trends in site-specific crude mortality rate 1965–2014. Cancer Statistics in Japan-2018, Tokyo, Japan, 2018; pp 40. https:// ganjoho.jp/data/reg_stat/statistics/brochure/2018/cancer_statistics_2018.pdf. Accessed Jan 2022 Trends in site-specific crude mortality rate 1965–2014. Cancer Statistics in Japan-2018, Tokyo, Japan, 2018; pp 40. https:// ganjoho.jp/data/reg_stat/statistics/brochure/2018/cancer_statistics_2018.pdf. Accessed Jan 2022
3.
Zurück zum Zitat Hamilton TD, Mahar AL, Haas B et al (2018) The impact of advanced age on short-term outcomes following gastric cancer resection: an ACS-NSQIP analysis. Gastric Cancer 21:710–719CrossRef Hamilton TD, Mahar AL, Haas B et al (2018) The impact of advanced age on short-term outcomes following gastric cancer resection: an ACS-NSQIP analysis. Gastric Cancer 21:710–719CrossRef
4.
Zurück zum Zitat Isobe T, Hashimoto K, Kizaki J et al (2012) Surgical procedure, complication, and prognosis for gastric cancer in the very elderly (<85): a retrospective study. Kurume Med J 59:61–70CrossRef Isobe T, Hashimoto K, Kizaki J et al (2012) Surgical procedure, complication, and prognosis for gastric cancer in the very elderly (<85): a retrospective study. Kurume Med J 59:61–70CrossRef
5.
Zurück zum Zitat Oohinata R, Iwasaki Y (2017) Gastrectomy for gastric cancer in elderly patients (in Japanese). Clin Gastroenterol 32:689–697 Oohinata R, Iwasaki Y (2017) Gastrectomy for gastric cancer in elderly patients (in Japanese). Clin Gastroenterol 32:689–697
6.
Zurück zum Zitat Terai T, Watanabe A, Kuroda Y et al (2019) Evaluation of surgical treatment for patients with gastric cancer aged over 80 years (in Japanese). J Nara Pref Gen Med C 23:23–27 Terai T, Watanabe A, Kuroda Y et al (2019) Evaluation of surgical treatment for patients with gastric cancer aged over 80 years (in Japanese). J Nara Pref Gen Med C 23:23–27
7.
Zurück zum Zitat Takahashi T, Kaneoka Y, Maeda A et al (2020) The preoperative prognostic nutrition index is a prognostic indicator for survival in elderly gastric cancer patients after gastrectomy: a propensity score-matched analysis. Updates Surgery 72:483–491CrossRef Takahashi T, Kaneoka Y, Maeda A et al (2020) The preoperative prognostic nutrition index is a prognostic indicator for survival in elderly gastric cancer patients after gastrectomy: a propensity score-matched analysis. Updates Surgery 72:483–491CrossRef
8.
Zurück zum Zitat Sakurai K, Muguruma K, Nagahara H et al (2015) The outcome of surgical treatment for elderly patients with gastric carcinoma. J Surg Oncol 111:848–854CrossRef Sakurai K, Muguruma K, Nagahara H et al (2015) The outcome of surgical treatment for elderly patients with gastric carcinoma. J Surg Oncol 111:848–854CrossRef
9.
Zurück zum Zitat Kiyokawa T, Hiki N, Nunobe S et al (2015) Feasibility of gastrectomy with standard lymphadenectomy for patients over 85 years old with gastric cancer. Ann Surg Oncol 22:3962–3969CrossRef Kiyokawa T, Hiki N, Nunobe S et al (2015) Feasibility of gastrectomy with standard lymphadenectomy for patients over 85 years old with gastric cancer. Ann Surg Oncol 22:3962–3969CrossRef
10.
Zurück zum Zitat Endo S, Shimizu Y, Ikenaga M et al (2017) Survival benefit of gastrectomy for gastric cancers in patients ≧85 years old: a retrospective propensity score-matched analysis. Surgery 161:984–994CrossRef Endo S, Shimizu Y, Ikenaga M et al (2017) Survival benefit of gastrectomy for gastric cancers in patients ≧85 years old: a retrospective propensity score-matched analysis. Surgery 161:984–994CrossRef
11.
Zurück zum Zitat Hikage M, Tokunaga M, Makuuchi R et al (2018) Surgical outcomes after gastrectomy in very elderly patients with gastric cancer. Surg Today 48:773–782CrossRef Hikage M, Tokunaga M, Makuuchi R et al (2018) Surgical outcomes after gastrectomy in very elderly patients with gastric cancer. Surg Today 48:773–782CrossRef
12.
Zurück zum Zitat Hsu JT, Liu MS, Wang F et al (2012) Standard radical gastrectomy in octogenarians and nonagenarians with gastric cancer: are short-term surgical results and long-term survival substantial? J Gastrointest Surg 16:728–737CrossRef Hsu JT, Liu MS, Wang F et al (2012) Standard radical gastrectomy in octogenarians and nonagenarians with gastric cancer: are short-term surgical results and long-term survival substantial? J Gastrointest Surg 16:728–737CrossRef
13.
Zurück zum Zitat Kwon IG, Cho I, Guner A et al (2015) Minimally invasive surgery as a treatment option for gastric cancer in the elderly: comparison with open surgery for patients 80 years and older. Surg Endosc 29:2321–2330CrossRef Kwon IG, Cho I, Guner A et al (2015) Minimally invasive surgery as a treatment option for gastric cancer in the elderly: comparison with open surgery for patients 80 years and older. Surg Endosc 29:2321–2330CrossRef
14.
Zurück zum Zitat Komori K, Kano K, Aoyama T et al (2020) The short- and long-term outcomes of gastrectomy in elderly patients with gastric cancer. In Vivo 34(5):2697–2703CrossRef Komori K, Kano K, Aoyama T et al (2020) The short- and long-term outcomes of gastrectomy in elderly patients with gastric cancer. In Vivo 34(5):2697–2703CrossRef
15.
Zurück zum Zitat Nashimoto A, Akazawa K, Isobe Y et al (2013) Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry. Gastric Cancer 16:1–27CrossRef Nashimoto A, Akazawa K, Isobe Y et al (2013) Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry. Gastric Cancer 16:1–27CrossRef
16.
Zurück zum Zitat Shimada H, Fukagawa T, Haga Y et al (2017) Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature. Ann Gastroenterol Surg 1:11–23CrossRef Shimada H, Fukagawa T, Haga Y et al (2017) Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature. Ann Gastroenterol Surg 1:11–23CrossRef
17.
Zurück zum Zitat Cho H, Tsuchida K, Iwasaki K et al (2021) Risk factors of post-operative pneumonia in elderly patients with gastric cancer: a retrospective cohort study. Jpn J Clin Oncol 51(7):1044–1050CrossRef Cho H, Tsuchida K, Iwasaki K et al (2021) Risk factors of post-operative pneumonia in elderly patients with gastric cancer: a retrospective cohort study. Jpn J Clin Oncol 51(7):1044–1050CrossRef
18.
Zurück zum Zitat Endo S, Fujiwara Y, Higashida M et al (2022) Survival analyses of elderly gastric cancer patients with or without surgery. Surg Today 52:75–83CrossRef Endo S, Fujiwara Y, Higashida M et al (2022) Survival analyses of elderly gastric cancer patients with or without surgery. Surg Today 52:75–83CrossRef
19.
Zurück zum Zitat Yamakawa Y, Bando E, Kawamura T et al (2014) A clinical study of surgical resection for patients over 85 years of age with gastric cancer (in Japanese). Jpn J Gastroenterol Surg 47:1–10CrossRef Yamakawa Y, Bando E, Kawamura T et al (2014) A clinical study of surgical resection for patients over 85 years of age with gastric cancer (in Japanese). Jpn J Gastroenterol Surg 47:1–10CrossRef
20.
Zurück zum Zitat Slagter AE, Tudelaet B, van Amelsfoort RM et al (2020) Older versus younger adults with gastric cancer receiving perioperative treatment: results from the CRITICS trial. Eur J Cancer 130:146–154CrossRef Slagter AE, Tudelaet B, van Amelsfoort RM et al (2020) Older versus younger adults with gastric cancer receiving perioperative treatment: results from the CRITICS trial. Eur J Cancer 130:146–154CrossRef
21.
Zurück zum Zitat Shen L, Zhang X, Kong L et al (2022) The clinical features, management, and survival of elderly patients with gastric cancer. J Gastrointest Oncol 13(2):605–614CrossRef Shen L, Zhang X, Kong L et al (2022) The clinical features, management, and survival of elderly patients with gastric cancer. J Gastrointest Oncol 13(2):605–614CrossRef
Metadaten
Titel
Systematic review and meta-analysis of reports of patients with gastric cancer aged 80 years and older
verfasst von
Chihiro Onagi
Mari Oba
Yoko Oshima
Hideaki Shimada
Publikationsdatum
06.07.2022
Verlag
Springer Nature Singapore
Erschienen in
International Cancer Conference Journal / Ausgabe 4/2022
Elektronische ISSN: 2192-3183
DOI
https://doi.org/10.1007/s13691-022-00563-w

Neu im Fachgebiet Onkologie

Körperlich fitte Krebskranke leben länger

Krebspatienten, auch und vor allem solche in fortgeschrittenen Stadien, profitieren offenbar von guter körperlicher Verfassung. Hohe Muskelkraft und kardiorespiratorische Fitness sind laut Ergebnissen einer Metaanalyse mit geringerer Mortalität assoziiert.

Kein (großer) Schutz vor Kolorektalkarzinom-Rezidiven durch ASS

Die erste Phase-3-Studie zum Nutzen von ASS in der adjuvanten Therapie des kolorektalen Karzinoms ist negativ verlaufen. Das abschließende Urteil über eine Sekundärprävention mit ASS ist trotzdem noch nicht gefallen.

Frühe CLL-Therapie: BTK-Hemmer verlängert EFS und PFS, aber nicht OS

Auch nach sechs Jahren ergibt sich kein Überlebensvorteil einer Therapie mit dem BTK-Hemmer Ibrutinib für Menschen mit frühem CLL-Stadium und erhöhtem Progressionsrisiko. Die Progressionsrate wird mit der Behandlung jedoch um über 80% gesenkt.

Adjuvantes Atezolizumab ohne Nutzen bei frühem TNBC

Patientinnen mit frühem triple-negativem Brustkrebs profitieren nach der Operation offenbar nicht von einer Zugabe des PD-L1-Hemmers Atezolizumab zur adjuvanten Standardchemotherapie. Die Studie, die das untersucht hat, wurde vorzeitig abgebrochen. Was könnte die schlechte Wirksamkeit erklären?

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.