Materials and Methods
Literature Search Strategy
Eligibility Criteria
Study Selection
Data Extraction and Quality Assessment
Outcomes
Results
Study Selection
Study Characteristics
Author/year | Country | Study period | Study design | Patients (n) | Control group | Primary tumor origin | QoL instrument (s) | Time points of assessment |
---|---|---|---|---|---|---|---|---|
Albertsmeier27 | Germany | NR | P | 40 | No | CRC 18%, gastric 15%, PMP 13%, ovarian 13%, meso 3% | EORTC QLQ-C30 | Baseline and 3, 9, and 18 months after surgery |
Bayat39 | Canada | 2011 to 2017 | P | 158 | No | Low-grade appendix 45%, CRC, high-grade appendix, small bowel 44%, peritoneal mesothelioma 11% | EORTC QLQ-C30, EORTC QLQ-CR29 | 3, 6, and 12 months |
Chia22 | Singapore | 2012 to 2015 | P | 23 | No | CRC 100% | EORTC QLQ-C30, EORTC QLQ-CR29 | Baseline and 3, 6, and 12 months after surgery |
Dodson28 | USA | 2000 to 2015 | P | 598 | No | CRC 22%, ovarian 3.7%, meso 8.4%, appendix 58%, small bowel 2%, others 6.2% | SF-36, FACT-C, BPI, CES-D, ECOG | Baseline and 3, 6, 12, and 24 months after surgery |
Hamilton29 | Canada | 2011 to 2014 | R | 42 | Yes | CRC 38%, meso 4.8%, appendix 55%, small bowel 2% | EORTC QLQ-C30 | 6 months after surgery |
Hill30 | USA | 2001 to 2009 | P | 61 | No | CRC 100% | SF-36, FACT-C, BPI, CES-D, ECOG | Baseline and 3, 6, and 12 months after surgery |
Hinkle31 | USA | NR | R | 36 | Yes | CRC 14%, ovarian 22%, meso 3%, appendix 39%, small bowel 3%, desmoplastic small round cell tumor 11%, primary peritoneal 6%, fibrolamellar hepatocellular carcinoma 3% | FACT-C | Baseline and 2 weeks, 1, 3, 6, and 12 months after surgery |
Kopanakis32 | Greece | 2011 to 2015 | P | 80 | No | CRC 24%, gastric 6%, PMP 19%, ovarian 35%, meso 9%, endometrial 5%, sarcoma 3% | FACT-C | Baseline and 1, 3, 6, 12, 18 and 24 months after surgery |
Macrí33 | Italy | 2003 to 2007 | P | 17 | No | CRC 41%, gastric 29%, ovarian 29% | FACT | Baseline and 3 and 6 months after surgery |
McQuellon35 | USA | 1995 to 1997 | P | 64 | No | CRC 25%, gastric 17%, PMP 2%, ovarian 6%, meso 9%, appendix 23%, small bowel 2%, sarcoma 5%, other gastrointestinal 2%, pancreas 2%, malignant neoplasms 8% | FACT-C, BPI, CES-D, ECOG, ADL subscale items | Baseline and 2 weeks, 3, 6, and 9 months after surgery |
McQuellon34 | USA | 1998 to 2005 | P | 96 | No | CRC 25%, gastric 4%, ovarian 5%, meso 9%, appendix 38%, miscellaneous 19% | SF-36, FACT-C, BPI, CES-D, ECOG | Baseline and 3, 6, and 12 months after surgery |
Passot36 | France | 2007 to 2011 | P | 216 | No | CRC 26%, gastric 6%, PMP 19%, meso 8%, ovarian 35%, primary serous peritoneal carcinoma 4%, others 5% | GIQLI | Baseline and 1, 3, 6, and 12 months after surgery |
Tsilimparis37 | Germany | 2005 to 2010 | P | 90 | No | CRC 21%, gastric 10%, PMP 16%, ovarian 19%, meso 13%, appendix 16%, small bowel 1%, malignant mixed mesodermal tumor 1% | EORTC QLQ-30 | Baseline and 1, 6, 12, 24, and 36 months after surgery |
Tuttle38 | USA | 2001 to 2005 | P | 35 | No | CRC 20%, gastric 6%, meso 9%, appendix 54%, small bowel 6%, gallbladder 3%, unknown 3% | FACT-C | Baseline and 4, 8, and 12 months after surgery |
Quality and Risk of Bias Assessment
Development of QoL During Follow-Up
Short-term symptom | Long-term symptom |
---|---|
< 6 months | 6–12 months |
Determinants of QoL
Determinant | Result | References |
---|---|---|
Age (years) | Younger age leads to a quicker recovery of QoL | |
Sex | Female sex is associated with lower QoL and lower emotional health | |
Primary tumor site | Ovarian carcinomas show slower recover of QoL Colon and gastric cancer show lower QoL but higher emotional health | |
Malignant ascites | Patients with malignant ascites show lower baseline scores of QoL but, after operation, immediate increase of QoL Patients without malignant ascites experience a decrease of QoL at 3 months, after which recovery begins | McQuellon35 |
Prolonged operation time | Longer duration of surgery is associated with diminished QoL | |
PCI | Patients with higher PCI suffer from greater decrease in QoL One study did not find a difference in QoL in patients with high or low PCI | |
CC score | Patients with higher CC score experience higher decrease of QoL | |
Type of bowel resection | Type of bowel resection does not influence QoL Social function scores are lower in patients with lower anterior resection | Bayat39 |
Adjuvant chemotherapy | Patients who receive adjuvant chemotherapy show lower QoL after CRS + HIPEC | |
Complication | Patients who experienced complications show slower recovery of QoL | |
Presence of Stoma | Presence of a stoma is negatively associated with QoL | |
Recurrence | Recurrence within 1 year leads to a lower QoL |