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08.07.2019 | Special Article

Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

verfasst von: Noam Yarom, Allan Hovan, Paolo Bossi, Anura Ariyawardana, Siri Beier Jensen, Margherita Gobbo, Hanan Saca-Hazboun, Abhishek kandwal, Alessandra Majorana, Giulia Ottaviani, Monica Pentenero, Narmin Mohammed Nasr, Tanya Rouleau, Anna Skripnik Lucas, Nathaniel Simon Treister, Eyal Zur, Vinisha Ranna, Anusha Vaddi, Karis Kin Fong Cheng, Andrei Barasch, Rajesh V. Lalla, Sharon Elad, On behalf of The Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO)

Erschienen in: Supportive Care in Cancer | Ausgabe 10/2019

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Abstract

Purpose

To update the clinical practice guidelines for the use of natural and miscellaneous agents for the prevention and/or treatment of oral mucositis (OM).

Methods

A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. The findings were added to the database used to develop the 2014 MASCC/ISOO clinical practice guidelines. Based on the evidence level, the following guidelines were determined: Recommendation, Suggestion, and No Guideline Possible.

Results

A total of 78 papers were identified within the scope of this section, out of which 29 were included in this part, and were analyzed with 27 previously reviewed studies. A new Suggestion was made for oral glutamine for the prevention of OM in head and neck (H&N) cancer patients receiving radiotherapy with concomitant chemotherapy. The previous Recommendation against the use of parenteral glutamine for the prevention of OM in hematopoietic stem cell transplantation (HSCT) patients was re-established. A previous Suggestion for zinc to prevent OM in H&N cancer patients treated with radiotherapy or chemo-radiotherapy was reversed to No Guideline Possible. No guideline was possible for other interventions.

Conclusions

Of the vitamins, minerals, and nutritional supplements studied for the management of OM, the evidence supports a Recommendation against parenteral glutamine in HSCT patients and a Suggestion in favor of oral glutamine in H&N cancer patients for the management of OM.

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Titel: Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements
verfasst von: Noam Yarom
Allan Hovan
Paolo Bossi
Anura Ariyawardana
Siri Beier Jensen
Margherita Gobbo
Hanan Saca-Hazboun
Abhishek kandwal
Alessandra Majorana
Giulia Ottaviani
Monica Pentenero
Narmin Mohammed Nasr
Tanya Rouleau
Anna Skripnik Lucas
Nathaniel Simon Treister
Eyal Zur
Vinisha Ranna
Anusha Vaddi
Karis Kin Fong Cheng
Andrei Barasch
Rajesh V. Lalla
Sharon Elad
On behalf of The Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO)
Publikationsdatum: 08.07.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 10/2019
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-019-04887-x

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Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines—part 1: vitamins, minerals, and nutritional supplements

Abstract

Purpose

Methods

Results

Conclusions

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Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie