The online version of this article (https://doi.org/10.1186/s12968-018-0428-0) contains supplementary material, which is available to authorized users.
Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk.
One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR).
One thousand five hundred fifteen (38% male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = − 0.001 (− 0.004–0.002),p = 0.62) and females (B = 0.000(95%CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = − 0.12(95%CI -0.16--0.091),p < 0.001 in males; B = − 0.12(95%CI -0.15--0.086),p < 0.001 in females).
Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.
Additional file 1: Table S1. Backward multivariable linear regression of (log) TAC for males and females in those with normal blood pressure (systolic blood pressure < 120 mmHg and diastolic blood pressure < 80 mmHg). Table S2. Backward multivariable linear regression of (Log) SAS in those with normal blood pressure (systolic blood pressure < 120 mmHg and diastolic blood pressure < 80 mmHg). Table S3. Multivariable linear regression of (log) LVMVR in those with normal blood pressure (systolic blood pressure < 120 mmHg and diastolic blood pressure < 80 mmHg). Figure S1. Scatter plots of BMI against LVMVR. (DOCX 152 kb)12968_2018_428_MOESM1_ESM.docx
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- Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study
Jonathan R. Weir-McCall
Stephen J. Gandy
Jill J. F. Belch
Shelley A. Henderson
Jennifer A. Macfarlane
Shona Z. Matthew
R. Stephen Nicholas
Allan D. Struthers
Richard D. White
J. Graeme Houston
- BioMed Central
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