nach oben

Nuclear Medicine and Molecular Imaging

Erschienen in:

09.12.2015 | Interesting Image

Systemic Immune Response to Vaccination on FDG-PET/CT

verfasst von: Mark Mingos, Stephanie Howard, Nicholas Giacalone, David Kozono, Heather Jacene

Erschienen in: Nuclear Medicine and Molecular Imaging | Ausgabe 4/2016

Einloggen, um Zugang zu erhalten

Abstract

A patient with newly diagnosed right lung cancer had transient ¹⁸F-fluorodeoxyglucose (FDG)-avid left axillary lymph nodes and intense splenic FDG uptake on positron emission tomography (PET)/computed tomography (CT). History revealed that the patient received a left-sided influenza vaccine 2–3 days before the examination. Although inflammatory FDG uptake in ipsilateral axillary nodes is reported, to our knowledge, this is the first report of visualization of the systemic immune response in the spleen related to the influenza vaccination on FDG-PET/CT. The history, splenic uptake and time course on serial FDG-PET/CT helped to avoid a false-positive interpretation for progressing lung cancer and alteration of the radiation therapy plan.

Panagiotidis E, Exarhos D, Housianakou I, et al. FDG uptake in axillary lymph nodes after vaccination against pandemic (H1N1). Eur Radiol. 2010;20:1251–3.CrossRefPubMed

Shirone N, Shinkai T, Yamane T, et al. Axillary lymph node accumulation on FDG-PET/CT after influenza vaccination. Ann Nucl Med. 2012;26:248–52.CrossRefPubMed

Thomassen A, Lerberg Nielsen A, Gerke O, et al. Duration of 18 F-FDG avidity in lymph nodes after pandemic H1N1v and seasonal influenza vaccination. Eur J Nucl Med Mol Imaging. 2011;38:894–8.CrossRefPubMed

Williams G, Joyce RM, Parker JA. False-positive axillary lymph node on FDG-PET/CT scan resulting from immunization. Clin Nucl Med. 2006;31:731–2.CrossRefPubMed

Nam HY, Kim SJ, Kim IJ, et al. The clinical implication and prediction of diffuse splenic FDG uptake during cancer surveillance. Clin Nucl Med. 2010;35:759–63.CrossRefPubMed

Salaun PY, Gastinne T, Bodet-Milin C, et al. Analysis of 18 F-FDG PET diffuse bone marrow uptake and splenic uptake in staging of Hodgkin’s lymphoma: a reflection of disease infiltration or just inflammation? Eur J Nucl Med Mol Imaging. 2009;36:1813–21.CrossRefPubMed

Basu S, Baghel NS. Intense FDG uptake in the spleen due to recent granulocyte-macrophage colony-stimulating factor administration: follow-up scan clarifying the situation. J Cancer Res Ther. 2011;7:228–9.CrossRefPubMed

Jacene HA, Ishimori T, Engles JM, et al. Effects of pegfilgrastim on normal biodistribution of 18 F-FDG: preclinical and clinical studies. J Nucl Med. 2006;47:950–6.PubMed

Liu Y. Clinical significance of diffusely increased splenic uptake on FDG-PET. Nucl Med Commun. 2009;30:763–9.CrossRefPubMed

10.

Sugawara Y, Zasadny KR, Kison PV, et al. Splenic fluorodeoxyglucose uptake increased by granulocyte colony-stimulating factor therapy: PET imaging results. J Nucl Med. 1999;40:1456–62.PubMed

11.

Jacene HA, Stearns V, Wahl RL. Lymphadenopathy resulting from acute hepatitis C infection mimicking metastatic breast carcinoma on FDG PET/CT. Clin Nucl Med. 2006;31:379–81.CrossRefPubMed

12.

Thomas DL, Syrbu S, Graham MM. Epstein-Barr virus mimicking lymphoma on FDG-PET/CT. Clin Nucl Med. 2009;34:891–3.CrossRefPubMed

13.

Balink H, Nabers H, Kibbelaar RE. High F-18 FDG uptake in bone marrow by cytokines secreting ectopic mucoepidermoid carcinoma. Clin Nucl Med. 2009;34:823–4.CrossRefPubMed

14.

Morooka M, Kubota K, Murata Y, et al. (18)F-FDG-PET/CT findings of granulocyte colony stimulating factor (G-CSF)-producing lung tumors. Ann Nucl Med. 2008;22:635–9.CrossRefPubMed

Titel: Systemic Immune Response to Vaccination on FDG-PET/CT
verfasst von: Mark Mingos
Stephanie Howard
Nicholas Giacalone
David Kozono
Heather Jacene
Publikationsdatum: 09.12.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Nuclear Medicine and Molecular Imaging / Ausgabe 4/2016
Print ISSN: 1869-3474
Elektronische ISSN: 1869-3482
DOI: https://doi.org/10.1007/s13139-015-0385-6

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2016

Indeterminate Findings on Oncologic PET/CT: What Difference Does PET/MRI Make?

Iodine Uptake Patterns on Post-ablation Whole Body Scans are Related to Elevated Serum Thyroglobulin Levels After Radioactive Iodine Therapy in Patients with Papillary Thyroid Carcinoma

Giant Cell Tumor with Secondary Aneurysmal Bone Cyst Shows Heterogeneous Metabolic Pattern on 18F-FDG PET/CT: A Case Report

Random Assay in Radioimmunoassay: Feasibility and Application Compared with Batch Assay

Clinical Meaning of Hot Uptake on Bone Scan in Symptomatic Accessory Navicular Bones

Visual Pattern and Serial Quantitation of 18F-Sodium Fluoride PET/CT in Asymptomatic Patients After Hip and Knee Arthroplasty