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Erschienen in: The journal of nutrition, health & aging 8/2019

30.08.2019

Systemic Oxidative Stress: A Key Point in Neurodegeneration — A Review

verfasst von: E. E. Martínez Leo, M. R. Segura Campos

Erschienen in: The journal of nutrition, health & aging | Ausgabe 8/2019

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Abstract

Systemic oxidative stress (SOS) has an important role in the mechanisms activation of neuronal death, involved in the neurodegenerative disease (ND) etiology. Brain is susceptible to oxidative stress injuries due to its high energy and metabolic request, therefore minimal imbalances of the redox state, as occurs in mitochondrial dysfunction, favour tissue injury and neuroinflammatory mechanisms activation. ND affect around the world about a billion people, without distinction of sex, educational level and economic status. Public measures generation that prevent ND from the SOS are possible promising therapeutic targets that could reduce the ND incidence. We discuss here the effects and mechanisms of SOS derived neurodegeneration, as well as the neuroinflammation repercussions for some cerebral structures.
Literatur
1.
Zurück zum Zitat Torrell G. Enfermedades neurodegenerativas. Actualización en Medicina de Familia. 2015; 11(7): 374–383. Torrell G. Enfermedades neurodegenerativas. Actualización en Medicina de Familia. 2015; 11(7): 374–383.
2.
Zurück zum Zitat National Institute of Neurological Disorders and Stroke. Neurodegenerative diseases. 2017. National Institute of Neurological Disorders and Stroke. Neurodegenerative diseases. 2017.
7.
Zurück zum Zitat Hetz C, Saxena S. ER stress and the unfolded protein response in neurodegeneration. Nat Rev Neurol. 2017; 13: 477–491 https://doi.org/PubMedCrossRef Hetz C, Saxena S. ER stress and the unfolded protein response in neurodegeneration. Nat Rev Neurol. 2017; 13: 477–491 https://​doi.​org/​PubMedCrossRef
8.
Zurück zum Zitat Harman D. Aging: a theory based on free radical and radiation chemistry. Int J Gerontol. 1956; 11: 298–300.CrossRef Harman D. Aging: a theory based on free radical and radiation chemistry. Int J Gerontol. 1956; 11: 298–300.CrossRef
16.
Zurück zum Zitat Jovell AJ. The XXI century patient. Anales del Sistema Sanitario de Navarra. 2006; 29(3): 85–90.PubMed Jovell AJ. The XXI century patient. Anales del Sistema Sanitario de Navarra. 2006; 29(3): 85–90.PubMed
20.
Zurück zum Zitat Hernández A, Rull A, Rodríguez E, Riera M, Luciano F, Camps J, Menéndez J, Joven J. Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities. Mediators Inflamm. 2013; 1–13. https://doi.org/10.1155/2013/135698.CrossRef Hernández A, Rull A, Rodríguez E, Riera M, Luciano F, Camps J, Menéndez J, Joven J. Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities. Mediators Inflamm. 2013; 1–13. https://​doi.​org/​10.​1155/​2013/​135698.CrossRef
30.
Zurück zum Zitat Hu Q, Ren J, Li G, Wu J, Wu X, Wang G, Gu G, et al. The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway. Cell Death Dis. 2018; 9(403) https://doi.org/10.1038/s41419-018-0436-x. Hu Q, Ren J, Li G, Wu J, Wu X, Wang G, Gu G, et al. The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway. Cell Death Dis. 2018; 9(403) https://​doi.​org/​10.​1038/​s41419-018-0436-x.
32.
Zurück zum Zitat Guillemot-Legris O, Muccioli G. Obesity- induced neuroinflammation: Beyond the hypothalamus. Trends Neurosci. 2017; 40(4): 237–253.PubMedCrossRef Guillemot-Legris O, Muccioli G. Obesity- induced neuroinflammation: Beyond the hypothalamus. Trends Neurosci. 2017; 40(4): 237–253.PubMedCrossRef
33.
34.
41.
Zurück zum Zitat Ouyang S, Hsuchou H, Kastin A, Wang Y, Yu C, Pan W. Diet-induced obesity suppresses expression of many proteins at the blood-brain barrier. J Cereb Blood Flow Metab. 2014; 34(1): 43–51.PubMedCrossRef Ouyang S, Hsuchou H, Kastin A, Wang Y, Yu C, Pan W. Diet-induced obesity suppresses expression of many proteins at the blood-brain barrier. J Cereb Blood Flow Metab. 2014; 34(1): 43–51.PubMedCrossRef
44.
Zurück zum Zitat Shrestha R, Millington O, Brewer J, Bushell T. Is Central Nervous System an Immune-Privileged site? Kathmandu University Med J. 2013; 41(1): 102–107.CrossRef Shrestha R, Millington O, Brewer J, Bushell T. Is Central Nervous System an Immune-Privileged site? Kathmandu University Med J. 2013; 41(1): 102–107.CrossRef
46.
Zurück zum Zitat Mizuno T. Neuron-microglia interactions in neuroinflammation. Clin Exp Neuroimmunol. 2015; 6: 225–231.CrossRef Mizuno T. Neuron-microglia interactions in neuroinflammation. Clin Exp Neuroimmunol. 2015; 6: 225–231.CrossRef
47.
Zurück zum Zitat Moraes JC, Coope A, Morari J, Cintra DE, Roman EA, Pauli JR, et al. High-fat diet induces apoptosis of hypothalamic neurons. PLoS One. 2009; 4(4): e5045.PubMedPubMedCentralCrossRef Moraes JC, Coope A, Morari J, Cintra DE, Roman EA, Pauli JR, et al. High-fat diet induces apoptosis of hypothalamic neurons. PLoS One. 2009; 4(4): e5045.PubMedPubMedCentralCrossRef
60.
Zurück zum Zitat Pelcastre D, Martínez-Leo E, Segura-Campos M. Functional and Biological Potential of Bioactive Compounds in Foods for the Dietary Treatment of Type 2 Diabetes Mellitus. In: Functional Food — Improve Health through Adequate Food, 1st edition. Ed. InTech; 2017. Pelcastre D, Martínez-Leo E, Segura-Campos M. Functional and Biological Potential of Bioactive Compounds in Foods for the Dietary Treatment of Type 2 Diabetes Mellitus. In: Functional Food — Improve Health through Adequate Food, 1st edition. Ed. InTech; 2017.
61.
Zurück zum Zitat Martínez-Leo E, Villavicencio T, Segura-Campos M. Functional Foods and Chemoprevention in Cancer. In: Grumezescu A, Holban AM, editors. Therapeutic Foods, 1st edition. Elsevier; 2017. Martínez-Leo E, Villavicencio T, Segura-Campos M. Functional Foods and Chemoprevention in Cancer. In: Grumezescu A, Holban AM, editors. Therapeutic Foods, 1st edition. Elsevier; 2017.
62.
Zurück zum Zitat Martínez-Leo E, Rojas R, Segura-Campos M. Protective Effect of Omega 3 Fatty Acids EPA and DHA in the Neurodegenerative Disease. In Mérillon JM, Ramawat KG, editors. Bioactive Molecules in Food, 1st edition. Ed. Springer International. 2018. Martínez-Leo E, Rojas R, Segura-Campos M. Protective Effect of Omega 3 Fatty Acids EPA and DHA in the Neurodegenerative Disease. In Mérillon JM, Ramawat KG, editors. Bioactive Molecules in Food, 1st edition. Ed. Springer International. 2018.
69.
Zurück zum Zitat Góngora JL. Caffeine as a preventive drug for Parkinson’s disease: epidemiologic evidence and experimental support. Rev Neurol. 2010; 50(4), 221–9. Góngora JL. Caffeine as a preventive drug for Parkinson’s disease: epidemiologic evidence and experimental support. Rev Neurol. 2010; 50(4), 221–9.
71.
Zurück zum Zitat Grimm MO, Stahlmann CP, Mett J, Haupenthal VJ, Zimmer VC, et al. Vitamin E: Curse or benefit in Alzheimer’s disease? A systematic investigation of the impact of α-, γ- and δ-tocopherol on Aβ generation and degradation in neuroblastoma cells. J Nutr Health Aging. 2015; 19:646–654 https://doi.org/10.1007/s12603-015-0506-z.PubMedCrossRef Grimm MO, Stahlmann CP, Mett J, Haupenthal VJ, Zimmer VC, et al. Vitamin E: Curse or benefit in Alzheimer’s disease? A systematic investigation of the impact of α-, γ- and δ-tocopherol on Aβ generation and degradation in neuroblastoma cells. J Nutr Health Aging. 2015; 19:646–654 https://​doi.​org/​10.​1007/​s12603-015-0506-z.PubMedCrossRef
72.
Metadaten
Titel
Systemic Oxidative Stress: A Key Point in Neurodegeneration — A Review
verfasst von
E. E. Martínez Leo
M. R. Segura Campos
Publikationsdatum
30.08.2019
Verlag
Springer Paris
Erschienen in
The journal of nutrition, health & aging / Ausgabe 8/2019
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-019-1240-8

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