Introduction
Methods
Data analysis
Results
OD cohort (n=103) | PPP cohort (n=103) | |||||
---|---|---|---|---|---|---|
Variable | ND, n=84 (81.6%) | T2D, n=19 (18.4%) | ND, n=32 (31.0%) | T2D, n=36 (35.0%) | IGT, n=15 (14.6%) | T3cD, n=20 (19.4%) |
Sex (female/male) | 46/38 | 6/13 | 16/16 | 13/23 | 6/9 | 6/14 |
Age (years) | 60±16 | 72±7** | 60±14 | 66±12 | 63±13 | 66±9 |
BMI (kg/m²) | 25.8±4.2 (n=83) | 26.5±3.6 | 24.9±3.4 | 25.8±5.0 | 25.7±3.5 | 26.0±3.9 |
Diabetes duration (years) | – | 9.9±7.4 (n=16) | – | 10.6±8.6 | – | 0.02±0.1 |
Blood glucose in ICU (mmol/l) | 8.0±1.8 (n=59) | 11.7±4.3** | – | – | – | – |
Fasting glucose (mmol/l) | – | – | 5.3±0.6 (n=27) | 8.0±2.7*** (n=30) | 5.3±0.4 | 6.7±1.7** |
HbA1c (mmol/mol) | – | – | 38±6.6 (n=31) | 58±15.3*** (n=34) | 40±3.3 | 46±9.8** |
HbA1c (%) | – | – | 5.6±0.6 (n=31) | 7.5±1.4*** (n=34) | 5.8±0.3 | 6.4±0.9** |
Blood glucose at 2 h in the OGTT (mmol/l) | – | – | 6.1±1.3 (n=27) | – | 9.2±0.8*** | 12.0±1.4*** (n=12) |
Histopathology | – | – | ||||
Chronic pancreatitis | – | – | 6 (18.7%) | 7 (19.4%) | 2 (13.3%) | 4 (20.0%) |
Benign tumour | – | – | 8 (25.0%) | 6 (16.7%) | 5 (33.3%) | 1 (5.0%) |
Malign tumour | – | – | 18 (56.3%) | 23 (63.9%) | 8 (53.3%) | 15 (75.0%) |
Islet OD | LCM islets PPP | ||||||||
---|---|---|---|---|---|---|---|---|---|
No. | Entrez ID | Symbol | Gene name | Probe ID | Ratio | Adj. p
| Probe ID | Ratio | Adj. p
|
1 | 51239/200539 |
ANKRD23/39
| Ankyrin repeat domain 23/39 | 229052_at | 0.585 | 1.14 × 10−2
| 1553366_s_at | 0.600 | 1.80 × 10−3
|
2 | 384 |
ARG2
| Arginase 2 | 203946_s_at | 0.605 | 3.28 × 10−4
| 203946_s_at | 0.463 | 1.47 × 10−9
|
3 | 430 |
ASCL2
| Achaete-scute complex homologue 2 | 229215_at | 0.540 | 2.52 × 10−3
| 229215_at | 0.463 | 1.74 × 10−8
|
4 | 92291 |
CAPN13
| Calpain 13 | 229499_at | 0.535 | 2.52 × 10−3
| 229499_at | 0.614 | 4.66 × 10−3
|
5 | 10752 |
CHL1
| Cell adhesion molecule with homology to L1CAM | 204591_at | 0.411 | 1.61 × 10−3
| 204591_at | 0.446 | 1.56 × 10−5
|
6 | 338557 |
FFAR4
| Free fatty acid receptor 4 | 240856_at | 0.604 | 1.10 × 10−2
| 240856_at | 0.566 | 1.79 × 10−3
|
7 | 57818 |
G6PC2
| Glucose-6-phosphatase, catalytic, 2 | 221453_at | 0.616 | 3.43 × 10−2
| 221453_at | 0.643 | 2.77 × 10−2
|
8 | 57467 |
HHATL
| Hedgehog acyltransferase-like | 223572_at | 0.388 | 1.09 × 10−4
| 223572_at | 0.415 | 4.44 × 10−4
|
9 | 27065 |
NSG1
| Neuron specific gene family member 1 | 209569_x_at | 0.624 | 2.41 × 10−2
| 209569_x_at | 0.610 | 8.59 × 10−4
|
10 | 64881 |
PCDH20
| Protocadherin 20 | 232054_at | 0.628 | 2.98 × 10−2
| 232054_at | 0.612 | 4.02 × 10−2
|
11 | 5502 |
PPP1R1A
| Protein phosphatase 1, regulatory subunit 1A | 235129_at | 0.419 | 3.07 × 10−4
| 235129_at | 0.475 | 5.54 × 10−6
|
12 | 6344 |
SCTR
| Secretin receptor | 1565737_at | 0.531 | 4.68 × 10−4
| 1565737_at | 0.495 | 8.30 × 10−4
|
13 | 6514 |
SLC2A2
| Solute carrier family 2, member 2 | 206535_at | 0.273 | 1.65 × 10−4
| 206535_at | 0.362 | 1.74 × 10−8
|
14 | 140738 |
TMEM37
| Transmembrane protein 37 | 1554485_s_at | 0.654 | 3.90 × 10−3
| 227190_at | 0.504 | 3.84 × 10−9
|
15 | 137970 |
UNC5D
| Unc-5 homologue D | 231325_at | 0.535 | 1.29 × 10−2
| 231325_at | 0.589 | 1.20 × 10−2
|
16 | 960 |
CD44
| CD44 molecule | 217523_at | 1.561 | 2.30 × 10−2
| 1557905_s_at | 1.681 | 1.84 × 10−2
|
17 | 284611 |
FAM102B
| Family with sequence similarity 102, member B | 226568_at | 1.538 | 9.05 × 10−3
| 226568_at | 1.636 | 2.15 × 10−2
|
18 | 114907 |
FBXO32
| F-box protein 32 | 232729_at | 1.716 | 1.51 × 10−3
| 225328_at | 1.505 | 7.66 × 10−3
|
19 | 131096 |
KCNH8
| Potassium voltage-gated channel, subfamily H, member 8 | 1552742_at | 1.529 | 1.09 × 10−2
| 1552742_at | 1.644 | 1.74 × 10−2
|
20 | 1600 |
DAB1
| Dab, reelin signal transducer, homologue 1 (Drosophila) | 228329_at | 0.616 | 3.90 × 10−2
| 228329_at | 1.551 | 4.59 × 10−2
|
21 | 2596 |
GAP43
| Growth associated protein 43 | 204471_at | 0.611 | 1.94 × 10−2
| 204471_at | 1.880 | 2.33 × 10−2
|
22 | 5166 |
PDK4
| Pyruvate dehydrogenase kinase, isozyme 4 | 1562321_at | 0.537 | 8.37 × 10−3
| 1562321_at | 2.120 | 4.06 × 10−2
|
23 | 6004 |
RGS16
| Regulator of G protein signalling 16 | 209324_s_at | 0.663 | 2.23 × 10−2
| 209324_s_at | 1.687 | 3.80 × 10−2
|