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Erschienen in: Journal of Cardiovascular Translational Research 5-6/2017

15.08.2017 | Correspondence

Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models

verfasst von: María Villalba-Orero, Marina López-Olañeta, Pablo García-Pavía, Enrique Lara-Pezzi

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 5-6/2017

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Abstract

Heart failure (HF) is a major cause of death and hospitalization worldwide. Despite advances in reducing mortality, prognosis remains poor and prevalence has reached epidemic proportions. The limitations of available preclinical models represent a major hurdle in the development of new therapies. Myocardial infarction (MI) is a main cause of HF in humans, and mouse models of MI are often used to study HF mechanisms and experimental treatments. We investigated whether MI in mice constitutes an appropriate model of HF. Permanent ligation of the left coronary artery induced severe and persistent systolic dysfunction and ventricular dilatation. Mouse follow-up for 10 months showed no significant evidence of lung congestion or other pulmonary defects associated with HF. No difference was observed in the capacity of infarcted mice to exercise compared to control animals. These results indicate that severe cardiac dysfunction in mice is not sufficient to demonstrate the presence of HF.
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Metadaten
Titel
Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models
verfasst von
María Villalba-Orero
Marina López-Olañeta
Pablo García-Pavía
Enrique Lara-Pezzi
Publikationsdatum
15.08.2017
Verlag
Springer US
Erschienen in
Journal of Cardiovascular Translational Research / Ausgabe 5-6/2017
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-017-9765-x

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