01.12.2017 | Review | Ausgabe 1/2017 Open Access

T-ALL and thymocytes: a message of noncoding RNAs
- Zeitschrift:
- Journal of Hematology & Oncology > Ausgabe 1/2017
Background
The noncoding RNAome
MicroRNAs
Long noncoding RNAs
T cell acute lymphoblastic leukemia
Methodological approaches in miRNA and long noncoding RNA research
MicroRNAs
Analytical platforms
In silico target gene prediction
Wet lab validation of miRNA target genes
In vivo studies of miRNA function in T-ALL development
LncRNAs
Analytical platforms
Guilt-by-association analysis
In vitro studies of lncRNAs
In vivo studies of lncRNAs
Oncomirs and tumor suppressor miRNAs in T-ALL
T-ALL miRNA oncogenes
T-ALL tumor suppressor miRNAs
T-ALL subtype-specific miRNAs
MiRNAs in the NOTCH1 regulatory network
MiRNAs up- and downstream of the TAL1 oncogene
miRBase release 21
|
Function
|
Direct targets
|
Refs
|
|
---|---|---|---|---|
miR-19a
|
hsa-miR-19a-3p
|
ONC
|
CYLD
|
|
ETP low
|
||||
miR-19b
|
hsa-miR-19b-3p
|
ONC
|
BIM, CYLD, PP2A, PRKAA1, PTEN
|
|
miR-20a
|
hsa-miR-20a-5p
|
ONC
|
BIM, PHF6, PTEN
|
[
121]
|
miR-21
|
hsa-miR-21-5p
|
ONC
|
PDCD4
|
[
101]
|
miR-26a
|
hsa-miR-26a-5p
|
ONC
|
BIM, PHF6, PTEN
|
[
121]
|
miR-29
|
hsa-miR-29a-3p
|
TSG
|
HBP1
|
[
129]
|
miR-30a
|
hsa-miR-30a-5p/3p
|
MYC repressed
|
NOTCH1
|
|
Targets NOTCH1
|
||||
miR-31
|
hsa-miR-31-5p
|
TSG
|
HBP1
|
[
130]
|
miR-92
|
hsa-miR-92a-3p
|
ONC
|
BIM, FBXW7, IKZF1, NF1, PTEN
|
[
121]
|
miR-101
|
hsa-miR-101-3p
|
Targets TAL1
|
TAL1
|
[
142]
|
miR-128-3p
|
hsa-miR-128-3p
|
ONC
|
PHF6
|
[
99]
|
miR-140-5p
|
hsa-miR-140-5p
|
Targets TAL1
|
TAL1
|
[
142]
|
miR-142-3p
|
hsa-miR-142-3p
|
ONC
|
cAMP, GRα, PKA
|
[
125]
|
miR-146b-5p
|
hsa-miR-146b-5p
|
TAL1 repressed
|
–
|
[
123]
|
miR-149*
|
hsa-miR-149-3p
|
ONC
|
JunB
|
[
126]
|
miR-150
|
hsa-miR-150-5p
|
TSG
|
MYB
|
[
130]
|
miR-155
|
hsa-miR-155-5p
|
TSG
|
HBP1, MYB
|
[
130]
|
miR-181a
|
hsa-miR-181a-5p
|
ONC
|
EGR1, NRARP
|
[
128]
|
miR-193b-3p
|
hsa-miR-193b-3p
|
TSG
|
MYB
|
[
131]
|
TAL-R low
|
||||
miR-196a
|
hsa-miR-196a-5p
|
IMM high
|
ERG
|
[
135]
|
miR-196b
|
hsa-miR-196b-5p
|
HOXA high
|
ERG
|
|
IMM high
|
||||
miR-200c
|
hsa-miR-200c-3p
|
TSG
|
HBP1, MYB
|
[
130]
|
miR-204
|
hsa-miR-204-5p
|
TSG
|
SOX4
|
[
132]
|
miR-221
|
hsa-miR-221-3p
|
ETP high
|
–
|
[
137]
|
miR-222
|
hsa-miR-222-3p
|
ETP high
|
ETS1
|
[
137]
|
miR-223
|
hsa-miR-223-3p
|
ONC
|
FBXW7
|
|
Myeloid high
|
||||
TAL-R high
|
||||
NOTCH1 activated
|
||||
TAL1 activated
|
||||
miR-363
|
hsa-miR-363-3p
|
ETP low
|
–
|
[
137]
|
miR-448
|
hsa-miR-448
|
Targets TAL1
|
TAL1
|
[
142]
|
miR-451
|
hsa-miR-451a
|
NOTCH1 repressed
|
c-MYC
|
[
138]
|
miR-485-5p
|
hsa-miR-485-5p
|
Targets TAL1
|
TAL1
|
[
142]
|
miR-520d-5p
|
hsa-miR-520d-5p
|
Targets TAL1
|
TAL1
|
[
142]
|
miR-590
|
hsa-miR-590-5p
|
ONC
|
RB1
|
[
127]
|
miR-92
|
hsa-miR-92a-3p
|
ONC
|
BIM, FBXW7, IKZF1, NF1, PTEN
|
[
121]
|