Erschienen in:
01.09.2012 | Case Report
T-cell receptor gene rearrangement in Epstein–Barr virus infectious mononucleosis
verfasst von:
L. Marbello, M. Riva, S. Veronese, A. M. Nosari, E. Ravano, A. Colosimo, L. Paris, E. Morra
Erschienen in:
Medical Oncology
|
Ausgabe 3/2012
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Abstract
This report describes the case of a previously healthy young man who presented with fever, pharyngitis, cervical lymphadenopathy, lymphocytosis, and severe thrombocytopenia. Serological tests for Epstein–Barr virus were diagnostic of a primary Epstein–Barr virus infectious mononucleosis but severe thrombocytopenia aroused the suspicion of a lymphoproliferative disease. T-cell receptor gene analysis performed on peripheral and bone marrow blood revealed a T-cell receptor γ-chain rearrangement without the evidence of malignancy using standard histologic and immunophenotipe studies. Signs and symptoms of the infectious disease, blood count, and T-cell receptor gene rearrangement resolved with observation without the evidence of emergence of a lymphoproliferative disease. In the contest of a suspected lymphoproliferative disease, molecular results should be integrated with all available data for an appropriate diagnosis.