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Erschienen in: Clinical and Experimental Medicine 3/2016

10.05.2015 | Original Article

T cells, mast cells and microvascular density in diffuse large B cell lymphoma

verfasst von: Christian Marinaccio, Giuseppe Ingravallo, Francesco Gaudio, Tommasina Perrone, Simona Ruggieri, Giuseppina Opinto, Beatrice Nico, Eugenio Maiorano, Giorgina Specchia, Domenico Ribatti

Erschienen in: Clinical and Experimental Medicine | Ausgabe 3/2016

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Abstract

Diffuse large B cell lymphoma (DLBCL) is recognized as the most common form of non-Hodgkin lymphoma (NHL), accounting for about 40 % of all cases of NHL. Among the cellular components of the tumor inflammatory infiltrate, T cells and mast cells have been demonstrated to be correlated with tumor angiogenesis. In this report, we have investigated CD3 and tryptase expression and their relationship with microvascular density (MVD) in DLBCL patients. Moreover, we determined the significance of CD3 expression in bulky and non-bulky disease. CD3 expression was significantly lower in bulky disease patients when compared to non-bulky ones. CD3 showed a positive correlation with tryptase and MVD, while multiple regression analysis efficaciously predicted MVD depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in DLBCL patients.
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Metadaten
Titel
T cells, mast cells and microvascular density in diffuse large B cell lymphoma
verfasst von
Christian Marinaccio
Giuseppe Ingravallo
Francesco Gaudio
Tommasina Perrone
Simona Ruggieri
Giuseppina Opinto
Beatrice Nico
Eugenio Maiorano
Giorgina Specchia
Domenico Ribatti
Publikationsdatum
10.05.2015
Verlag
Springer International Publishing
Erschienen in
Clinical and Experimental Medicine / Ausgabe 3/2016
Print ISSN: 1591-8890
Elektronische ISSN: 1591-9528
DOI
https://doi.org/10.1007/s10238-015-0354-5

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