Skip to main content
Erschienen in: International Journal of Computer Assisted Radiology and Surgery 1/2019

06.10.2018 | Original Article

Tactile sensor-based real-time clustering for tissue differentiation

verfasst von: Ralf Stroop, Makoto Nakamura, Johan Schoukens, David Oliva Uribe

Erschienen in: International Journal of Computer Assisted Radiology and Surgery | Ausgabe 1/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Reliable intraoperative delineation of tumor from healthy brain tissue is essentially based on the neurosurgeon’s visual aspect and tactile impression of the considered tissue, which is—due to inherent low brain consistency contrast—a challenging task. Development of an intelligent artificial intraoperative tactile perception will be a relevant task to improve the safety during surgery, especially when—as for neuroendoscopy—tactile perception will be damped or—as for surgical robotic applications—will not be a priori existent. Here, we present the enhancements and the evaluation of a tactile sensor based on the use of a piezoelectric tactile sensor.

Methods

A robotic-driven piezoelectric bimorph sensor was excited using multisine to obtain the frequency response function of the contact between the sensor and fresh ex vivo porcine tissue probes. Based on load-depth, relaxation and creep response tests, viscoelastic parameters E1 and E2 for the elastic moduli and η for the viscosity coefficient have been obtained allowing tissue classification. Data analysis was performed by a multivariate cluster algorithm.

Results

Cluster algorithm assigned five clusters for the assignment of white matter, basal ganglia and thalamus probes. Basal ganglia and white matter have been assigned to a common cluster, revealing a less discriminatory power for these tissue types, whereas thalamus was exclusively delineated; gray matter could even be separated in subclusters.

Conclusions

Bimorph-based, multisine-excited tactile sensors reveal a high sensitivity in ex vivo tissue-type differentiation. Although, the sensor principle has to be further evaluated, these data are promising.
Literatur
1.
Zurück zum Zitat Kuhnt D, Bauer MHA, Nimsky C (2012) Brain shift compensation and neurosurgical image fusion using intraoperative MRI: current status and future challenges. Crit Rev Biomed Eng 40(3):175–185CrossRefPubMed Kuhnt D, Bauer MHA, Nimsky C (2012) Brain shift compensation and neurosurgical image fusion using intraoperative MRI: current status and future challenges. Crit Rev Biomed Eng 40(3):175–185CrossRefPubMed
2.
Zurück zum Zitat van Leyen K, Klotzsch C, Harrer JU (2011) Brain tumor imaging with transcranial sonography: state of the art and review of the literature. Ultraschall in der Medizin 32(6):572–581CrossRefPubMed van Leyen K, Klotzsch C, Harrer JU (2011) Brain tumor imaging with transcranial sonography: state of the art and review of the literature. Ultraschall in der Medizin 32(6):572–581CrossRefPubMed
3.
Zurück zum Zitat Finke M, Kantelhardt S, Schlaefer A, Bruder R, Lankenau E, Giese A, Schweikard A (2012) Automatic scanning of large tissue areas in neurosurgery using optical coherence tomography. Int J Med Robot Comput Assist Surg MRCAS 8(3):327–336CrossRef Finke M, Kantelhardt S, Schlaefer A, Bruder R, Lankenau E, Giese A, Schweikard A (2012) Automatic scanning of large tissue areas in neurosurgery using optical coherence tomography. Int J Med Robot Comput Assist Surg MRCAS 8(3):327–336CrossRef
4.
Zurück zum Zitat Kirsch M, Schackert G, Salzer R, Krafft C (2010) Raman spectroscopic imaging for in vivo detection of cerebral brain metastases. Anal Bioanal Chem 398(4):1707–1713CrossRefPubMed Kirsch M, Schackert G, Salzer R, Krafft C (2010) Raman spectroscopic imaging for in vivo detection of cerebral brain metastases. Anal Bioanal Chem 398(4):1707–1713CrossRefPubMed
5.
Zurück zum Zitat Steiner G, Sobottka SB, Koch E, Schackert G, Kirsch M (2011) Intraoperative imaging of cortical cerebral perfusion by time-resolved thermography and multivariate data analysis. J Biomed Opt 16(1):16001CrossRef Steiner G, Sobottka SB, Koch E, Schackert G, Kirsch M (2011) Intraoperative imaging of cortical cerebral perfusion by time-resolved thermography and multivariate data analysis. J Biomed Opt 16(1):16001CrossRef
6.
Zurück zum Zitat Colditz MJ, van Leyen K, Jeffree RL (2012) Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects. J Clin Neurosci 19(12):1611–1616CrossRefPubMed Colditz MJ, van Leyen K, Jeffree RL (2012) Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects. J Clin Neurosci 19(12):1611–1616CrossRefPubMed
7.
Zurück zum Zitat Kern TA (2009) Engineering haptic devices: a beginner’s guide for engineers. Springer, DordrechtCrossRef Kern TA (2009) Engineering haptic devices: a beginner’s guide for engineers. Springer, DordrechtCrossRef
8.
Zurück zum Zitat Lee MH, Nicholls HR (1999) Review article tactile sensing for mechatronics—a state of the art survey. Mechatronics 9(1):1–31CrossRef Lee MH, Nicholls HR (1999) Review article tactile sensing for mechatronics—a state of the art survey. Mechatronics 9(1):1–31CrossRef
9.
Zurück zum Zitat Eltaib MEH, Hewit JR (2003) Tactile sensing technology for minimal access surgery—a review. Mechatronics 13(10):1163–1177CrossRef Eltaib MEH, Hewit JR (2003) Tactile sensing technology for minimal access surgery—a review. Mechatronics 13(10):1163–1177CrossRef
10.
Zurück zum Zitat Rahim RA, Waduth MFA, Jaafar HI, Ayob NMN, Leow PL (2012) Current trend of tactile sensor in advanced applications. Sens Transducers 143(8):32–43 Rahim RA, Waduth MFA, Jaafar HI, Ayob NMN, Leow PL (2012) Current trend of tactile sensor in advanced applications. Sens Transducers 143(8):32–43
11.
Zurück zum Zitat Tiwana MI, Redmond SJ, Lovell NH (2012) A review of tactile sensing technologies with applications in biomedical engineering. Sens Actuators A 179:17–31CrossRef Tiwana MI, Redmond SJ, Lovell NH (2012) A review of tactile sensing technologies with applications in biomedical engineering. Sens Actuators A 179:17–31CrossRef
12.
13.
Zurück zum Zitat Saccomandi P, Schena E, Oddo C, Zollo L, Silvestri S, Guglielmelli E (2014) Microfabricated tactile sensors for biomedical applications: a review. Biosensors 4(4):422–448CrossRefPubMedCentralPubMed Saccomandi P, Schena E, Oddo C, Zollo L, Silvestri S, Guglielmelli E (2014) Microfabricated tactile sensors for biomedical applications: a review. Biosensors 4(4):422–448CrossRefPubMedCentralPubMed
14.
Zurück zum Zitat Bonomo C, Brunetto P, Fortuna L, Giannone P, Graziani S, Strazzeri S (2008) A tactile sensor for biomedical applications based on IPMCs. IEEE Sens J 8(8):1486–1493CrossRef Bonomo C, Brunetto P, Fortuna L, Giannone P, Graziani S, Strazzeri S (2008) A tactile sensor for biomedical applications based on IPMCs. IEEE Sens J 8(8):1486–1493CrossRef
15.
Zurück zum Zitat Brunetto P, Fortuna L, Giannone P, Graziani S, Pagano F (2010) A resonant vibrating tactile probe for biomedical applications based on IPMC. IEEE Trans Instrum Meas 59(5):1453–1462CrossRef Brunetto P, Fortuna L, Giannone P, Graziani S, Pagano F (2010) A resonant vibrating tactile probe for biomedical applications based on IPMC. IEEE Trans Instrum Meas 59(5):1453–1462CrossRef
16.
Zurück zum Zitat Hemsel T, Stroop R, Uribe DO, Wallaschek J (2007) Resonant vibrating sensors for tactile tissue differentiation. J Sound Vib 308(3–5):441–446CrossRef Hemsel T, Stroop R, Uribe DO, Wallaschek J (2007) Resonant vibrating sensors for tactile tissue differentiation. J Sound Vib 308(3–5):441–446CrossRef
17.
Zurück zum Zitat Tanaka Y, Yu Q, Doumoto K, Sano A, Hayashi Y, Fujii M, Kajita Y, Mizuno M, Wakabayashi T, Fujimoto H (2010) Development of a real-time tactile sensing system for brain tumor diagnosis. Int J Comput Assist Radiol Surg 5(4):359–367CrossRefPubMed Tanaka Y, Yu Q, Doumoto K, Sano A, Hayashi Y, Fujii M, Kajita Y, Mizuno M, Wakabayashi T, Fujimoto H (2010) Development of a real-time tactile sensing system for brain tumor diagnosis. Int J Comput Assist Radiol Surg 5(4):359–367CrossRefPubMed
18.
Zurück zum Zitat Johannsmann D, Langhoff A, Bode B, Mpoukouvalas K, Heimann A, Kempski O, Charalampaki P (2013) Towards in vivo differentiation of brain tumor versus normal tissue by means of torsional resonators. Sens Actuators A 190:25–31CrossRef Johannsmann D, Langhoff A, Bode B, Mpoukouvalas K, Heimann A, Kempski O, Charalampaki P (2013) Towards in vivo differentiation of brain tumor versus normal tissue by means of torsional resonators. Sens Actuators A 190:25–31CrossRef
19.
Zurück zum Zitat Uribe DO, Schoukens J, Stroop R (2018) Improved tactile resonance sensor for robotic assisted surgery. Mech Syst Signal Process 99:600–610CrossRef Uribe DO, Schoukens J, Stroop R (2018) Improved tactile resonance sensor for robotic assisted surgery. Mech Syst Signal Process 99:600–610CrossRef
20.
Zurück zum Zitat Uribe DO, Stroop R, Wallaschek J (2009) Piezoelectric self-sensing system for tactile intraoperative brain tumor delineation in neurosurgery. In: Conference proceedings: annual international conference of the IEEE engineering in medicine and biology society, vol 2009. IEEE Engineering in Medicine and Biology Society, pp 737–740 Uribe DO, Stroop R, Wallaschek J (2009) Piezoelectric self-sensing system for tactile intraoperative brain tumor delineation in neurosurgery. In: Conference proceedings: annual international conference of the IEEE engineering in medicine and biology society, vol 2009. IEEE Engineering in Medicine and Biology Society, pp 737–740
21.
Zurück zum Zitat Uribe DO, Zhu H, Wallaschek J (2010) Automated measurement system for mechanical characterization of soft tissues and phantoms. In: 2010 International conference on electronic devices, systems and applications (ICEDSA), pp 227–231 Uribe DO, Zhu H, Wallaschek J (2010) Automated measurement system for mechanical characterization of soft tissues and phantoms. In: 2010 International conference on electronic devices, systems and applications (ICEDSA), pp 227–231
22.
Zurück zum Zitat Madsen EL, Hobson MA, Shi H, Varghese T, Frank GR (2005) Tissue-mimicking agar/gelatin materials for use in heterogeneous elastography phantoms. Phys Med Biol 50(23):5597–5618CrossRefPubMedCentralPubMed Madsen EL, Hobson MA, Shi H, Varghese T, Frank GR (2005) Tissue-mimicking agar/gelatin materials for use in heterogeneous elastography phantoms. Phys Med Biol 50(23):5597–5618CrossRefPubMedCentralPubMed
23.
Zurück zum Zitat Brunetto P, Fortuna L, Giannone P, Graziani S, Strazzeri S (2010) Static and dynamic characterization of the temperature and humidity influence on IPMC actuators. IEEE Trans Instrum Meas 59(4):893–908CrossRef Brunetto P, Fortuna L, Giannone P, Graziani S, Strazzeri S (2010) Static and dynamic characterization of the temperature and humidity influence on IPMC actuators. IEEE Trans Instrum Meas 59(4):893–908CrossRef
24.
Zurück zum Zitat Kollar I (1993) On frequency-domain identification of linear systems. IEEE Trans Instrum Meas 42(1):2–6CrossRef Kollar I (1993) On frequency-domain identification of linear systems. IEEE Trans Instrum Meas 42(1):2–6CrossRef
25.
Zurück zum Zitat Cheng L, Xia X, Scriven LE, Gerberich WW (2005) Spherical-tip indentation of viscoelastic material. Mech Mater 37(1):213–226CrossRef Cheng L, Xia X, Scriven LE, Gerberich WW (2005) Spherical-tip indentation of viscoelastic material. Mech Mater 37(1):213–226CrossRef
26.
Zurück zum Zitat Seber GAF (2004) Multivariate observations. Wiley, New York Seber GAF (2004) Multivariate observations. Wiley, New York
27.
Zurück zum Zitat Green MA, Bilston LE, Sinkus R (2008) In vivo brain viscoelastic properties measured by magnetic resonance elastography. NMR Biomed 21(7):755–764CrossRefPubMed Green MA, Bilston LE, Sinkus R (2008) In vivo brain viscoelastic properties measured by magnetic resonance elastography. NMR Biomed 21(7):755–764CrossRefPubMed
28.
Zurück zum Zitat Jalkanen V, Andersson BM, Bergh A, Ljungberg B, Lindahl OA (2006) Resonance sensor measurements of stiffness variations in prostate tissue in vitro—a weighted tissue proportion model. Physiol Meas 27(12):1373–1386CrossRefPubMed Jalkanen V, Andersson BM, Bergh A, Ljungberg B, Lindahl OA (2006) Resonance sensor measurements of stiffness variations in prostate tissue in vitro—a weighted tissue proportion model. Physiol Meas 27(12):1373–1386CrossRefPubMed
Metadaten
Titel
Tactile sensor-based real-time clustering for tissue differentiation
verfasst von
Ralf Stroop
Makoto Nakamura
Johan Schoukens
David Oliva Uribe
Publikationsdatum
06.10.2018
Verlag
Springer International Publishing
Erschienen in
International Journal of Computer Assisted Radiology and Surgery / Ausgabe 1/2019
Print ISSN: 1861-6410
Elektronische ISSN: 1861-6429
DOI
https://doi.org/10.1007/s11548-018-1869-5

Weitere Artikel der Ausgabe 1/2019

International Journal of Computer Assisted Radiology and Surgery 1/2019 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.