Takotsubo cardiomyopathy is a relatively rare, unique entity that has only recently been widely appreciated [
1]. Although the exact cause of the syndrome remains unknown, many underlying mechanisms have been, so far, proposed including diffuse epicardial arteries spasm, coronary microcirculation dysfunction, cathecolamines-induced myocardial dysfunction, and neurologically-mediated myocardial stunning [
1]. Acute stress has been indicated as a common trigger for the transient LV apical ballooning syndrome [
1,
5]. Interestingly, it has been reported that the majority of patients experiencing the syndrome were post-menopausal Japanese women who present ischemic-like chest pain early after an episode of acute emotional or physiologic stress [
1,
5]. In general most patients were women (ranging from 82 to 100% in different series) with a mean age at presentation of approximately 70 years [
1]. Explanation for this dramatic sex and age discrepancy can only be speculated, however it may be possibly related to post-menopausal alterations of endothelial function secondary to reduced estrogen levels and microcirculatory vasomotor reactivity to cathecolamine-mediated stimuli [
1]. Initially, takotsubo cardiomyopathy was believed to have a peculiar geographic and racial distribution given the predilection for Japanese women and the lack of reports of case-series from other countries [
1,
2]. Desmet et al. in 2003 first described the syndrome in a series of 13 Caucasian patients from Belgium [
3]; more recently other groups from both North America and Europe reported series of LV apical ballooning in white women, the largest, by Sharkey et al., involving 22 subjects [
1,
4,
6,
7]. The present case is a typical example of stress-induced takotsubo cardiomyopathy in a Caucasian Italian postmenopausal woman.