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Erschienen in: Breast Cancer Research 1/2000

01.12.2001 | Paper Report

Tamoxifen, angiogenesis, oestrogens and animal models

verfasst von: Valerie Speirs

Erschienen in: Breast Cancer Research | Ausgabe 1/2000

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Excerpt

Angiogenesis is the remodelling of existing vasculature either by formation of new blood vessels or regression of superfluous vessels. In normal adults there is relatively little angiogenesis, but it is well documented that neovascularisation is required for tumour growth beyond a critical size. The (ER) antagonist TAM is currently the first line therapy for treatment of hormone sensitive breast cancer. However, besides its anti-oestrogenic effects, TAM has also been shown to have anti-angiogenic properties. Although there has been much work on the former, the anti-angiogenic actions of TAM are not well understood. …
Literatur
1.
Zurück zum Zitat Blackwell KL, Haroon ZA, Shan S, Saito W, Broadwater G, Greenberg CS, Dewhirst MW: Tamoxifen inhibits angiogenesis in oestrogen receptor-negative animal models. Clin Cancer Res. 2001, 6: 4359-4364. Blackwell KL, Haroon ZA, Shan S, Saito W, Broadwater G, Greenberg CS, Dewhirst MW: Tamoxifen inhibits angiogenesis in oestrogen receptor-negative animal models. Clin Cancer Res. 2001, 6: 4359-4364.
Metadaten
Titel
Tamoxifen, angiogenesis, oestrogens and animal models
verfasst von
Valerie Speirs
Publikationsdatum
01.12.2001
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 1/2000
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr-2001-66721

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