Electronic supplementary material
Patients and methods
Patient selection and clinical assessments
Results and discussion
KIAA1549-BRAF fusion, a recurrent oncogenic driver in sporadic pilocytic astrocytoma, is described here in a spindle cell neoplasm for the first time.
This case is the first report any tumor expressing KIAA1549-BRAF fusion with PTEN loss to be successfully treated by targeted therapy.
Genomic profiling based on Next-generation sequencing (NGS) may be of great relevance in the management of patient with solid tumors that defy pathologic definition, as this case demonstrates that such diagnostics can reveal unexpected but effective avenues of targeted treatment.