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Breast Cancer Research

Erschienen in:

01.08.2011 | Editorial

Targeting bone metastases starting from the preneoplastic niche: home sweet home

verfasst von: Daniele Santini, Bruno Vincenzi, Francesco Pantano, Giuseppe Tonini, Francesco Bertoldo

Erschienen in: Breast Cancer Research | Ausgabe 4/2011

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Abstract

The metastatic process is a multistep coordinated event with a high degree of efficiency. Specific subpopulations of cancer stem cells, with tumor-initiating and migratory capacity, can selectively migrate towards sites that are able to promote survival and/or proliferation of metastatic tumor cells through a microenvironment modification. Cross-talk between the bone microenvironment and cancer cells can facilitate bone tropism of cancer cells. Fully understanding this complexity represents a major challenge in anti-cancer research and a mandatory step towards the development of new drugs potentially able not only to reduce the consequences of bone lesions but also to target the metastatic process in visceral sites.

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Titel: Targeting bone metastases starting from the preneoplastic niche: home sweet home
verfasst von: Daniele Santini
Bruno Vincenzi
Francesco Pantano
Giuseppe Tonini
Francesco Bertoldo
Publikationsdatum: 01.08.2011
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 4/2011
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2911

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Targeting bone metastases starting from the preneoplastic niche: home sweet home

Abstract

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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